iPTMnet Report for Q14774 (HLX)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14774 / HLX_HUMAN
Protein Name H2.0-like homeobox protein
Gene Name Name: HLX
Synonyms:HLX1;
Organism Homo sapiens (Human)

PRO ID PR:Q14774
DAG View
PRO Name H2.0-like homeobox protein (human)
Definition An H2.0-like homeobox protein that is encoded in the genome of human.
Short Label hHLX
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14774 (HLX) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S113 Phosphorylation IEDB 32387766
S152 Phosphorylation PhosphoSitePlus
T154 Phosphorylation PhosphoSitePlus
K175 Ubiquitination PhosphoSitePlus
T271 Phosphorylation PhosphoSitePlus
Y272 Phosphorylation PhosphoSitePlus
S277 Phosphorylation PhosphoSitePlus
S366 Phosphorylation HPRD 17081983
S400 Phosphorylation HPRD   PhosphoSitePlus 19413330
T404 Phosphorylation HPRD   PhosphoSitePlus 19413330
S477 Phosphorylation HPRD   PhosphoSitePlus 19413330


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S152 L152 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K175 R175 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T271 M271 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y272 H272 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S277 L277 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T404 K404 Biomuta DOID:9256 / colorectal cancer [ cosmic ]