iPTMnet Report for Q14766 (LTBP1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14766 / LTBP1_HUMAN
Protein Name Latent-transforming growth factor beta-binding protein 1 precursor
Gene Name Name: LTBP1
Organism Homo sapiens (Human)

PRO ID PR:Q14766
DAG View
PRO Name latent-transforming growth factor beta-binding protein 1 (human)
Definition A latent TGF-beta-binding protein 1 that is encoded in the genome of human.
Short Label hLTBP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14766 (LTBP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S66 Phosphorylation PhosphoSitePlus
N167 N-Glycosylation GlyGen 29391424
S278 O-Glycosylation GlyGen 30459171
T290 O-Glycosylation GlyGen 30459171
S296 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T304 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
K318 Ubiquitination PhosphoSitePlus
S321 Phosphorylation PhosphoSitePlus
S325 Phosphorylation PhosphoSitePlus
T326 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
N347 N-Glycosylation GlyGen 23090970, 29741879, 29391424, ...24190977
T357 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
N378 N-Glycosylation GlyGen 23090970, 29741879, 29671580, ...29391424, 24190977
S438 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S460 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T461 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 30459171, 25813380
T463 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T467 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T469 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
S470 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S501 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
Y523 Phosphorylation PhosphoSitePlus
T531 Phosphorylation PhosphoSitePlus
T533 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S536 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T537 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S539 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S647 O-Glycosylation GlyGen   UniProt 34411563
T661 O-Glycosylation GlyGen 30459171, 25813380
S738 Phosphorylation PhosphoSitePlus
S768 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T769 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 30459171, 25813380
T785 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T801 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 30459171
S810 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T831 O-Glycosylation GlyGen 30459171
T845 O-Glycosylation GlyGen 30459171, 25813380
S846 O-Glycosylation GlyGen 30459171, 25813380
T859 O-Glycosylation GlyGen 25813380
T869 O-Glycosylation GlyGen 30459171, 25813380
T872 O-Glycosylation GlyGen 30459171
T878 O-Glycosylation GlyGen 30459171
Y896 Phosphorylation PhosphoSitePlus
T897 Phosphorylation PhosphoSitePlus
Y901 Phosphorylation PhosphoSitePlus
Y904 Phosphorylation PhosphoSitePlus
T920 O-Glycosylation GlyGen 30459171
S937 O-Glycosylation GlyGen   UniProt 34411563
Y988 Phosphorylation PhosphoSitePlus
T991 Phosphorylation PhosphoSitePlus
S1019 O-Glycosylation GlyGen   UniProt 34411563
S1059 O-Glycosylation GlyGen   UniProt 34411563
S1100 O-Glycosylation GlyGen 34411563
S1141 O-Glycosylation GlyGen   UniProt 34411563
N1163 N-Glycosylation GlyGen 29391424
S1183 O-Glycosylation GlyGen 34411563
S1224 O-Glycosylation GlyGen   UniProt 34411563
N1250 N-Glycosylation GlyGen 24190977
N1251 N-Glycosylation GlyGen 24190977
N1262 N-Glycosylation GlyGen 24190977
S1266 O-Glycosylation GlyGen 34411563
T1333 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
N1366 N-Glycosylation GlyGen 29741879, 24190977, 8617200, ...10677208
S1413 Phosphorylation PhosphoSitePlus
S1414 Phosphorylation PhosphoSitePlus   UniProt 26091039
S1415 Phosphorylation PhosphoSitePlus
Y1422 Phosphorylation PhosphoSitePlus
S1488 O-Glycosylation GlyGen   UniProt 34411563
S1597 Phosphorylation PhosphoSitePlus   UniProt 18088087
Y1600 Phosphorylation PhosphoSitePlus
T1601 O-Glycosylation GlyGen 30459171
T1601 Phosphorylation PhosphoSitePlus
S1616 Phosphorylation PhosphoSitePlus
S1687 O-Glycosylation GlyGen   UniProt 34411563
Y1688 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
N378 N-Glycosylation PRO 29671580
Site PTM Type PTM Enzyme Score Source PMID
S408 Phosphorylation PhosphoSitePlus


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000036461 (hLTBP1/iso:2/SigPep-) Interaction PR:000000617 (TGFB1/iso:1/LAP) PRO 10930463


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N167 T167 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S296 N296 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K318 N318 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S325 F325 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
N347 K347 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T357 N357 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
N378 K378 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S408 F408 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S408 Y408 Biomuta DOID:4159 / skin cancer [ cosmic ]
S460 * Biomuta DOID:1319 / brain cancer [ cosmic ]
T467 I467 Biomuta DOID:4159 / skin cancer [ cosmic ]
S501 * Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ]
T537 A537 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S539 Y539 Biomuta DOID:4159 / skin cancer [ cosmic ]
T785 A785 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T785 N785 Biomuta DOID:4159 / skin cancer [ cosmic ]
S810 L810 Biomuta DOID:4159 / skin cancer [ cosmic ]
T845 K845 Biomuta DOID:1324 / lung cancer [ cosmic ]
S846 T846 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y988 H988 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1059 A1059 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S1059 F1059 Biomuta DOID:363 / uterine cancer [ icgc ]
S1100 Y1100 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S1100 F1100 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1224 F1224 Biomuta DOID:363 / uterine cancer [ icgc ]
S1266 P1266 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1266 F1266 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
S1413 L1413 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
Y1422 N1422 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1597 I1597 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]