iPTMnet Report for Q14765 (STAT4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14765 / STAT4_HUMAN
Protein Name Signal transducer and activator of transcription 4
Gene Name Name: STAT4
Organism Homo sapiens (Human)

PRO ID PR:Q14765
DAG View
PRO Name signal transducer and activator of transcription 4 (human)
Definition A signal transducer and activator of transcription 4 that is encoded in the genome of human.
Short Label hSTAT4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14765 (STAT4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S130 Phosphorylation PhosphoSitePlus
S137 Phosphorylation PhosphoSitePlus
K151 Ubiquitination PhosphoSitePlus
T284 Phosphorylation PhosphoSitePlus
T287 Phosphorylation PhosphoSitePlus
Y288 Phosphorylation PhosphoSitePlus
T298 Phosphorylation PhosphoSitePlus
S362 Phosphorylation PhosphoSitePlus
T369 Phosphorylation PhosphoSitePlus
S371 Phosphorylation PhosphoSitePlus
S386 Phosphorylation PhosphoSitePlus
S394 Phosphorylation PhosphoSitePlus
S396 Phosphorylation PhosphoSitePlus
K562 Ubiquitination PhosphoSitePlus
Y645 Phosphorylation PhosphoSitePlus
K667 Acetylation PhosphoSitePlus   UniProt 35614130
K691 Acetylation PhosphoSitePlus
Y693 Phosphorylation O60674 (JAK2) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 28877912, 24842371, 32213463, ...16324152, 17110450, 10961885
S713 Phosphorylation PhosphoSitePlus
S721 Phosphorylation Q16539 (MAPK14) , P52564 (MAP2K6) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 10961885, 16324152, 17502367
S733 Phosphorylation PhosphoSitePlus
T735 O-Glycosylation GlyGen 30379171, 29351928
T736 O-Glycosylation GlyGen 30379171, 29351928
T739 O-Glycosylation GlyGen 30379171, 29351928
S743 Phosphorylation PhosphoSitePlus
Y745 Phosphorylation PhosphoSitePlus
S746 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S130 F130 Biomuta DOID:4159 / skin cancer [ cosmic ]
K151 R151 Biomuta DOID:1324 / lung cancer [ cosmic ]
T287 A287 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y288 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S362 * Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
T369 A369 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S371 I371 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S386 Y386 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S386 F386 Biomuta DOID:4159 / skin cancer [ cosmic ]
S396 * Biomuta DOID:4362 / cervical cancer [ cosmic ]
S721 Y721 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S743 Y743 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]