Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14764 / MVP_HUMAN
Protein Name Major vault protein
Gene Name Name: MVP
Synonyms:LRP;
Organism Homo sapiens (Human)

PRO ID PR:Q14764
DAG View
PRO Name major vault protein (human)
Definition A major vault protein that is encoded in the genome of human.
Short Label hMVP
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14764 (MVP) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378, 22223895
Y13 Phosphorylation phospho.ELM   PhosphoSitePlus 15592455
Y15 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18083107
T52 Phosphorylation PhosphoSitePlus
Y58 Phosphorylation PhosphoSitePlus
C59 S-Nitrosylation dbSNO 2212679, 22126794
K107 Ubiquitination PhosphoSitePlus
K132 Ubiquitination PhosphoSitePlus
K136 Ubiquitination PhosphoSitePlus
K348 Ubiquitination PhosphoSitePlus
K370 Ubiquitination PhosphoSitePlus
Y389 Phosphorylation PhosphoSitePlus
K394 Ubiquitination PhosphoSitePlus
K397 Ubiquitination PhosphoSitePlus
K429 Ubiquitination PhosphoSitePlus
K440 Ubiquitination PhosphoSitePlus
K444 Ubiquitination PhosphoSitePlus
S445 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y460 Phosphorylation PhosphoSitePlus
Y471 Phosphorylation PhosphoSitePlus
K560 Ubiquitination PhosphoSitePlus
S563 Phosphorylation PhosphoSitePlus
S585 Phosphorylation PhosphoSitePlus
K593 Ubiquitination PhosphoSitePlus
T608 Phosphorylation PhosphoSitePlus
S636 Phosphorylation PhosphoSitePlus
S637 Phosphorylation PhosphoSitePlus
K674 Ubiquitination PhosphoSitePlus
K692 Ubiquitination PhosphoSitePlus
K701 Ubiquitination PhosphoSitePlus
K745 Ubiquitination PhosphoSitePlus
K747 Ubiquitination PhosphoSitePlus
T755 Phosphorylation PhosphoSitePlus
Y772 Phosphorylation PhosphoSitePlus
K793 Ubiquitination PhosphoSitePlus
S805 Phosphorylation PhosphoSitePlus
T806 Phosphorylation PhosphoSitePlus
T830 Phosphorylation HPRD 20068231
T833 Phosphorylation HPRD 20068231
S864 Phosphorylation PhosphoSitePlus
S867 Phosphorylation PhosphoSitePlus
S873 Phosphorylation HPRD   PhosphoSitePlus 20166139, 18452278
S876 Phosphorylation HPRD   PhosphoSitePlus 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K136 N136 Biomuta DOID:3571 / liver cancer [ icgc ]
K136 T136 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S445 I445 Biomuta DOID:3571 / liver cancer [ icgc ]
S585 F585 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T806 S806 Biomuta DOID:2531 / hematologic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S867 N867 Biomuta DOID:0070003 / blastoma [ cosmic ]
S873 F873 Biomuta DOID:1909 / melanoma [ tcga ]