iPTMnet Report for Q14738 (PPP2R5D)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14738 / 2A5D_HUMAN
Protein Name Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform
Gene Name Name: PPP2R5D
Organism Homo sapiens (Human)

PRO ID PR:Q14738
DAG View
PRO Name serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (human)
Definition A serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform that is encoded in the genome of human.
Short Label hPPP2R5D
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14738 (PPP2R5D) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T18 Phosphorylation PhosphoSitePlus
T33 O-Glycosylation GlyGen 23301498, 34019948, 35132862
S54 Phosphorylation PhosphoSitePlus
S60 Phosphorylation PhosphoSitePlus 17110335, 9688562
S60 Phosphorylation O14757 (CHEK1) PhosphoSitePlus 17110335
S60 Phosphorylation P17612 (PRKACA) PhosphoSitePlus 9688562
S62 Phosphorylation PhosphoSitePlus
T63 Phosphorylation PhosphoSitePlus   UniProt 23186163
T67 Phosphorylation PhosphoSitePlus
K71 Ubiquitination PhosphoSitePlus
K73 Ubiquitination PhosphoSitePlus
Y74 Phosphorylation PhosphoSitePlus
S75 Phosphorylation PhosphoSitePlus 9688562
S75 Phosphorylation P17612 (PRKACA) PhosphoSitePlus 9688562
K82 Ubiquitination PhosphoSitePlus
S88 Phosphorylation IEDB   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18669648, 32387766
S89 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S90 Phosphorylation PhosphoSitePlus   UniProt 23186163
S95 Phosphorylation PhosphoSitePlus
K96 Ubiquitination PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
S109 Phosphorylation PhosphoSitePlus
K121 Ubiquitination PhosphoSitePlus
K140 Ubiquitination PhosphoSitePlus
K232 Ubiquitination PhosphoSitePlus
K268 Ubiquitination PhosphoSitePlus
K332 Ubiquitination PhosphoSitePlus
K334 Ubiquitination PhosphoSitePlus
K367 Ubiquitination PhosphoSitePlus
K371 Ubiquitination PhosphoSitePlus
K409 Ubiquitination PhosphoSitePlus
Y451 Phosphorylation PhosphoSitePlus
T461 Phosphorylation PhosphoSitePlus
K479 Ubiquitination PhosphoSitePlus
C484 Methylation IEDB 31844290
Y488 Phosphorylation PhosphoSitePlus
K489 Ubiquitination PhosphoSitePlus
K500 Ubiquitination PhosphoSitePlus
K508 Ubiquitination PhosphoSitePlus
Y519 Phosphorylation PhosphoSitePlus
R523 Methylation PhosphoSitePlus
Y532 Phosphorylation PhosphoSitePlus
S533 Phosphorylation PhosphoSitePlus
T536 Phosphorylation PhosphoSitePlus
T538 Phosphorylation PhosphoSitePlus
K548 Ubiquitination PhosphoSitePlus
T553 Phosphorylation PhosphoSitePlus
K560 Ubiquitination PhosphoSitePlus
K572 Ubiquitination PhosphoSitePlus
S573 Phosphorylation phospho.ELM   PhosphoSitePlus   Signor   UniProt 21406692, 23186163, 9688562, ...18669648, 17301223
S573 Phosphorylation P17612 (PRKACA) PhosphoSitePlus   Signor 9688562, 17301223
Y580 Phosphorylation PhosphoSitePlus
T581 Phosphorylation PhosphoSitePlus
K583 Ubiquitination PhosphoSitePlus
K589 Ubiquitination PhosphoSitePlus
S598 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 16565220
Site PTM Type PTM Enzyme Score Source PMID
S88 Phosphorylation HPRD 18669648, 20068231
S89 Phosphorylation HPRD 18669648, 17081983, 20068231
S90 Phosphorylation HPRD 20068231
T461 Phosphorylation HPRD 19651622
S573 Phosphorylation HPRD 17322306, 18767875, 18669648, ...19651622, 20068231
S598 Phosphorylation HPRD 16565220
Site PTM Type PTM Enzyme Score Source PMID
T429 Phosphorylation HPRD 19651622
S541 Phosphorylation HPRD 17322306, 18767875, 18669648, ...19651622, 20068231
S566 Phosphorylation HPRD 16565220
Site PTM Type PTM Enzyme Score Source PMID
T355 Phosphorylation HPRD 19651622
S467 Phosphorylation HPRD 17322306, 18767875, 18669648, ...19651622, 20068231
S492 Phosphorylation HPRD 16565220


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T63 M63 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
T67 M67 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S90 Y90 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
C484 F484 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
R523 Q523 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R523 * Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
T538 I538 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K583 Q583 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]