Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14694 / UBP10_HUMAN
Protein Name Ubiquitin carboxyl-terminal hydrolase 10
Gene Name Name: USP10
Synonyms:KIAA0190;
Organism Homo sapiens (Human)

PRO ID PR:Q14694
DAG View
PRO Name ubiquitin carboxyl-terminal hydrolase 10 (human)
Definition A ubiquitin carboxyl-terminal hydrolase 10 that is encoded in the genome of human.
Short Label hUSP10
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14694 (USP10) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Ubiquitination PRO
A2 Acetylation UniProt 20068231
S5 Phosphorylation PhosphoSitePlus
S14 Phosphorylation PhosphoSitePlus
T24 Phosphorylation PhosphoSitePlus   UniProt 20068231
C40 S-Nitrosylation dbSNO 26338901
T42 Phosphorylation Q13315 (ATM) PhosphoSitePlus   RLIMS-P   UniProt 20096447
Y54 Phosphorylation PhosphoSitePlus
S68 Phosphorylation PhosphoSitePlus
T70 Phosphorylation PhosphoSitePlus
T74 Phosphorylation PhosphoSitePlus
S76 Phosphorylation PhosphoSitePlus   RLIMS-P 26876938
Y77 Phosphorylation PhosphoSitePlus
S81 Phosphorylation PhosphoSitePlus
T82 Phosphorylation PhosphoSitePlus
T95 Phosphorylation PhosphoSitePlus
T100 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
Y110 Phosphorylation PhosphoSitePlus
K154 Ubiquitination PhosphoSitePlus
Y159 Phosphorylation PhosphoSitePlus
Y160 Phosphorylation PhosphoSitePlus
S161 Phosphorylation PhosphoSitePlus
Y162 Phosphorylation PhosphoSitePlus
S203 Phosphorylation PhosphoSitePlus
T205 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T208 Phosphorylation PhosphoSitePlus
S211 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 15302935
S215 Phosphorylation PhosphoSitePlus
T216 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S218 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S220 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S226 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
C254 S-Nitrosylation dbSNO 26338901
T263 Phosphorylation PhosphoSitePlus
S265 Phosphorylation PhosphoSitePlus
S309 Phosphorylation PhosphoSitePlus
S321 Phosphorylation PhosphoSitePlus   UniProt 24275569
T327 Phosphorylation PhosphoSitePlus
S329 Phosphorylation PhosphoSitePlus
S337 Phosphorylation Q13315 (ATM) PhosphoSitePlus   RLIMS-P   UniProt 20096447
S341 Phosphorylation PhosphoSitePlus
S355 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y359 Phosphorylation PhosphoSitePlus
Y364 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 16964243
S365 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 20068231, 18669648, 16964243, ...24275569
S370 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 16964243, ...20068231
K376 Ubiquitination PhosphoSitePlus
K381 Ubiquitination PhosphoSitePlus
K395 Ubiquitination PhosphoSitePlus
K408 Ubiquitination PhosphoSitePlus
K488 Ubiquitination PhosphoSitePlus
Y503 Phosphorylation PhosphoSitePlus
K512 Ubiquitination PhosphoSitePlus
S516 Phosphorylation PhosphoSitePlus
K518 Ubiquitination PhosphoSitePlus
Y527 Phosphorylation PhosphoSitePlus
K544 Ubiquitination PhosphoSitePlus
S547 Phosphorylation PhosphoSitePlus   UniProt 23186163
S549 Phosphorylation PhosphoSitePlus
K552 Ubiquitination PhosphoSitePlus
S556 Phosphorylation PhosphoSitePlus
S563 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
S576 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17287340, 17081983, ...15302935, 18318008, 18669648, 17693683, 23186163, 17487921, 19690332, 20068231
T600 Phosphorylation PhosphoSitePlus
Y659 Phosphorylation PhosphoSitePlus
K662 Ubiquitination PhosphoSitePlus
K664 Ubiquitination PhosphoSitePlus
S670 Phosphorylation PhosphoSitePlus
T674 Phosphorylation PhosphoSitePlus
K677 Ubiquitination PhosphoSitePlus
Y691 Phosphorylation PhosphoSitePlus
K693 Ubiquitination PhosphoSitePlus
T694 Phosphorylation PhosphoSitePlus
K699 Ubiquitination PhosphoSitePlus
K702 Ubiquitination PhosphoSitePlus
S713 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K714 Acetylation PhosphoSitePlus
K714 Ubiquitination PhosphoSitePlus
S718 Phosphorylation PhosphoSitePlus
K722 Ubiquitination PhosphoSitePlus
K780 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S5 Phosphorylation HPRD 20068231
Y8 Phosphorylation HPRD 20068231
S14 Phosphorylation HPRD 20068231
T24 Phosphorylation HPRD 20068231
T74 Phosphorylation HPRD 20068231
Y77 Phosphorylation HPRD 20230923
T100 Phosphorylation HPRD 19413330, 18669648
T205 Phosphorylation HPRD 18669648
T208 Phosphorylation HPRD 19413330, 19664995
S211 Phosphorylation HPRD 18669648, 15302935, 19664995, ...20068231
T216 Phosphorylation HPRD 18669648, 19664995
S218 Phosphorylation HPRD 18669648
S220 Phosphorylation HPRD 18669648
S226 Phosphorylation HPRD 18669648
S354 Phosphorylation HPRD 20068231
S355 Phosphorylation HPRD 18669648
Y364 Phosphorylation HPRD 18669648, 19664994, 16964243
S365 Phosphorylation HPRD 19413330, 16964243, 18452278, ...19651622, 18669648, 20068231
S370 Phosphorylation HPRD 19413330, 16964243, 19664994, ...19664995, 18669648, 20068231
S547 Phosphorylation HPRD 19413330, 20068231
S549 Phosphorylation HPRD 20068231
S563 Phosphorylation HPRD 18669648, 20068231
S576 Phosphorylation HPRD 19413330, 17287340, 20230923, ...15302935, 18452278, 19651622, 18669648, 17693683, 20166139, 19415658, 20068231
S713 Phosphorylation HPRD 18669648
S718 Phosphorylation HPRD 20068231


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049631 (hUSP10/InitMet-/UbiqLys+) ub PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 T2 Biomuta DOID:1909 / melanoma [ cosmic ]
Y54 C54 Biomuta DOID:3070 / malignant glioma [ cosmic, icgc, tcga ]
T95 A95 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
K154 Q154 Biomuta DOID:9256 / colorectal cancer [ icgc ]
Y160 C160 Biomuta DOID:363 / uterine cancer [ tcga ]
S161 I161 Biomuta DOID:3070 / malignant glioma [ tcga ]
S203 P203 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S215 F215 Biomuta DOID:1909 / melanoma [ tcga ] DOID:263 / kidney cancer [ tcga ]
S226 I226 Biomuta DOID:1909 / melanoma [ cosmic ]
S265 L265 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S309 R309 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
T327 M327 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K408 T408 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S549 N549 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K702 E702 Biomuta DOID:5041 / esophageal cancer [ icgc ]