iPTMnet Report for Q14686 (NCOA6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14686 / NCOA6_HUMAN
Protein Name Nuclear receptor coactivator 6
Gene Name Name: NCOA6
Synonyms:AIB3,KIAA0181,RAP250,TRBP;
Organism Homo sapiens (Human)

PRO ID PR:Q14686
DAG View
PRO Name nuclear receptor coactivator 6 (human)
Definition A nuclear receptor coactivator 6 that is encoded in the genome of human.
Short Label hNCOA6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14686 (NCOA6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K59 Acetylation PhosphoSitePlus
K62 Acetylation PhosphoSitePlus
R95 Methylation PhosphoSitePlus   UniProt 24129315
S144 Phosphorylation PhosphoSitePlus
R148 Methylation PhosphoSitePlus
R160 Methylation PhosphoSitePlus
R413 Methylation PhosphoSitePlus
S884 Phosphorylation neXtProt   PhosphoSitePlus   UniProt 11773444, 11301320
S884 Phosphorylation P28482 (MAPK1) neXtProt   PhosphoSitePlus 11773444, 11301320
S926 Phosphorylation PhosphoSitePlus
S967 O-Glycosylation GlyGen 23301498, 26960196, 33214551, ...35138101, 30379171, 32574038, 34019948, 35254053, 35132862, 30620550, 28604694, 31492838, 29351928, 28657654, 29237092, 30059200
R1047 Methylation PhosphoSitePlus
R1058 Methylation PhosphoSitePlus
S1091 Phosphorylation PhosphoSitePlus
R1096 Methylation PhosphoSitePlus
T1103 Phosphorylation PhosphoSitePlus
T1211 Phosphorylation PhosphoSitePlus
S1216 O-Glycosylation GlyGen 23301498, 26960196, 33214551, ...35138101, 30379171, 32574038, 34019948, 35254053, 35132862, 30620550, 28604694, 31492838, 29351928, 28657654, 29237092, 30059200
S1216 Phosphorylation PhosphoSitePlus
T1224 O-Glycosylation GlyGen 23301498, 26960196, 33214551, ...35138101, 30379171, 32574038, 34019948, 35254053, 35132862, 30620550, 28604694, 31492838, 29351928, 28657654, 29237092, 30059200
S1231 O-Glycosylation GlyGen 23301498, 26960196, 33214551, ...35138101, 30379171, 32574038, 34019948, 35254053, 35132862, 30620550, 28604694, 31492838, 29351928, 28657654, 29237092, 30059200
T1232 O-Glycosylation GlyGen 23301498, 26960196, 33214551, ...35138101, 30379171, 32574038, 34019948, 35254053, 35132862, 30620550, 28604694, 31492838, 29351928, 28657654, 29237092, 30059200
S1235 O-Glycosylation GlyGen 23301498, 26960196, 33214551, ...35138101, 30379171, 32574038, 34019948, 35254053, 35132862, 30620550, 28604694, 31492838, 29351928, 28657654, 29237092, 30059200
S1238 O-Glycosylation GlyGen 32574038
S1240 Phosphorylation HPRD   PhosphoSitePlus 18452278
T1299 Phosphorylation PhosphoSitePlus
S1307 Phosphorylation PhosphoSitePlus
S1312 Phosphorylation PhosphoSitePlus
T1321 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 15302935, 20068231
S1325 Phosphorylation PhosphoSitePlus
K1339 Acetylation PhosphoSitePlus
S1343 Phosphorylation PhosphoSitePlus
S1458 Phosphorylation PhosphoSitePlus
S1465 Phosphorylation PhosphoSitePlus
S1472 Phosphorylation PhosphoSitePlus
S1481 Phosphorylation PhosphoSitePlus
T1516 Phosphorylation PhosphoSitePlus
S1641 O-Glycosylation GlyGen 23301498, 26960196, 33214551, ...35138101, 30379171, 32574038, 34019948, 35254053, 35132862, 30620550, 28604694, 31492838, 29351928, 28657654, 29237092, 30059200
S1645 O-Glycosylation GlyGen 23301498, 26960196, 33214551, ...35138101, 30379171, 32574038, 34019948, 35254053, 35132862, 30620550, 28604694, 31492838, 29351928, 28657654, 29237092, 30059200
T1685 O-Glycosylation GlyGen 23301498, 26960196, 33214551, ...35138101, 30379171, 32574038, 34019948, 35254053, 35132862, 30620550, 28604694, 31492838, 29351928, 28657654, 29237092, 30059200
S1745 Phosphorylation PhosphoSitePlus
T1749 Phosphorylation PhosphoSitePlus
S1751 Phosphorylation PhosphoSitePlus
S1756 O-Glycosylation GlyGen 34846842
S1809 Phosphorylation PhosphoSitePlus
T1878 Phosphorylation PhosphoSitePlus
T1880 Phosphorylation PhosphoSitePlus
S1892 Phosphorylation PhosphoSitePlus
S1916 O-Glycosylation GlyGen 23301498, 26960196, 33214551, ...35138101, 30379171, 32574038, 34019948, 35254053, 35132862, 30620550, 28604694, 31492838, 29351928, 28657654, 29237092, 30059200
S1916 Phosphorylation PhosphoSitePlus
T1920 O-Glycosylation GlyGen 23301498, 26960196, 33214551, ...35138101, 30379171, 32574038, 34019948, 35254053, 35132862, 30620550, 28604694, 31492838, 29351928, 28657654, 29237092, 30059200
T1932 O-Glycosylation GlyGen 23301498, 26960196, 33214551, ...35138101, 30379171, 32574038, 34019948, 35254053, 35132862, 30620550, 28604694, 31492838, 29351928, 28657654, 29237092, 30059200
T1933 O-Glycosylation GlyGen 23301498, 26960196, 33214551, ...35138101, 35254053, 30379171, 32574038, 32938750, 34019948, 30059200, 35132862, 30620550, 28604694, 31492838, 29351928, 28657654, 29237092
S2018 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 18452278
T2020 Phosphorylation PhosphoSitePlus
S2038 Phosphorylation PhosphoSitePlus
S2039 Phosphorylation PhosphoSitePlus
S2043 Phosphorylation PhosphoSitePlus
S2045 Phosphorylation PhosphoSitePlus
S2046 Phosphorylation PhosphoSitePlus
T2048 Phosphorylation PhosphoSitePlus
S2053 Phosphorylation PhosphoSitePlus
S2057 Phosphorylation PhosphoSitePlus


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:Q92793-1 (hCREBBP/iso:1) Interaction PR:Q14686 (hNCOA6) PRO 10866662


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R95 H95 Biomuta DOID:1612 / breast cancer [ icgc ]
R95 C95 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R160 K160 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R1058 K1058 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T1299 A1299 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic, icgc ]
S1307 F1307 Biomuta DOID:3571 / liver cancer [ cosmic ]
S1465 L1465 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1481 Y1481 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S1645 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S1745 F1745 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1751 Y1751 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1756 Y1756 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1809 I1809 Biomuta DOID:1324 / lung cancer [ cosmic ]
T1933 K1933 Biomuta DOID:4159 / skin cancer [ cosmic ]
S2039 F2039 Biomuta DOID:4159 / skin cancer [ cosmic ]