iPTMnet Report for Q14683 (SMC1A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14683 / SMC1A_HUMAN
Protein Name Structural maintenance of chromosomes protein 1A
Gene Name Name: SMC1A
Synonyms:DXS423E,KIAA0178,SB1.8,SMC1,SMC1L1;
Organism Homo sapiens (Human)

PRO ID PR:Q14683
DAG View
PRO Name structural maintenance of chromosomes protein 1A (human)
Definition A structural maintenance of chromosomes protein 1A that is encoded in the genome of human.
Short Label hSMC1A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14683 (SMC1A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K5 Ubiquitination PhosphoSitePlus
K13 Ubiquitination PhosphoSitePlus
K16 Ubiquitination PhosphoSitePlus
T28 Phosphorylation HPRD   PhosphoSitePlus 20068231
K52 Ubiquitination PhosphoSitePlus
K72 Ubiquitination PhosphoSitePlus
S85 Phosphorylation PhosphoSitePlus
R92 Methylation PhosphoSitePlus
Y105 Phosphorylation PhosphoSitePlus
K106 Acetylation PhosphoSitePlus
K106 Ubiquitination PhosphoSitePlus
K110 Ubiquitination PhosphoSitePlus
Y117 Phosphorylation PhosphoSitePlus
K123 Ubiquitination PhosphoSitePlus
K149 Methylation PhosphoSitePlus
T152 Phosphorylation PhosphoSitePlus
R160 Methylation PhosphoSitePlus
S161 Phosphorylation PhosphoSitePlus
Y168 Phosphorylation PhosphoSitePlus
K170 Ubiquitination PhosphoSitePlus
K177 Ubiquitination PhosphoSitePlus
T182 Phosphorylation PhosphoSitePlus
Y186 Phosphorylation PhosphoSitePlus
K189 Ubiquitination PhosphoSitePlus
K190 Ubiquitination PhosphoSitePlus
K213 Ubiquitination PhosphoSitePlus
K237 Ubiquitination PhosphoSitePlus
K240 Ubiquitination PhosphoSitePlus
K282 Acetylation PhosphoSitePlus
S289 Phosphorylation PhosphoSitePlus
K294 Ubiquitination PhosphoSitePlus
K300 Ubiquitination PhosphoSitePlus
S318 Phosphorylation PhosphoSitePlus
Y326 Phosphorylation PhosphoSitePlus
S358 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17525332, 18077418, 20068231
S360 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 17525332, 23186163, 18077418, ...15302935, 18669648, 30702968, 20068231
T366 Phosphorylation PhosphoSitePlus
K373 Ubiquitination PhosphoSitePlus
K395 Ubiquitination PhosphoSitePlus
K401 Ubiquitination PhosphoSitePlus
R406 Methylation PhosphoSitePlus
K433 Ubiquitination PhosphoSitePlus
K437 Acetylation PhosphoSitePlus
K437 Ubiquitination PhosphoSitePlus
Y441 Phosphorylation PhosphoSitePlus
K446 Ubiquitination PhosphoSitePlus
K454 Methylation PhosphoSitePlus
K467 Ubiquitination PhosphoSitePlus
K475 Ubiquitination PhosphoSitePlus
K500 Ubiquitination PhosphoSitePlus
K508 Ubiquitination PhosphoSitePlus
Y511 Phosphorylation PhosphoSitePlus
K528 Ubiquitination PhosphoSitePlus
Y530 Phosphorylation PhosphoSitePlus
K536 Acetylation PhosphoSitePlus
K536 Ubiquitination PhosphoSitePlus
K540 Acetylation PhosphoSitePlus
K540 Ubiquitination PhosphoSitePlus
K561 Ubiquitination PhosphoSitePlus
Y575 Phosphorylation PhosphoSitePlus
K579 Acetylation PhosphoSitePlus
K579 Ubiquitination PhosphoSitePlus
K584 Ubiquitination PhosphoSitePlus
Y600 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
K607 Ubiquitination PhosphoSitePlus
Y611 Phosphorylation PhosphoSitePlus
K637 Ubiquitination PhosphoSitePlus
T644 Phosphorylation PhosphoSitePlus
K648 Acetylation PhosphoSitePlus   UniProt 19608861
K648 Ubiquitination PhosphoSitePlus
S653 Phosphorylation PhosphoSitePlus
S657 Phosphorylation PhosphoSitePlus
K660 Ubiquitination PhosphoSitePlus
K669 Ubiquitination PhosphoSitePlus
K686 Ubiquitination PhosphoSitePlus
R699 Methylation PhosphoSitePlus
S703 Phosphorylation PhosphoSitePlus
K713 Acetylation PhosphoSitePlus   UniProt 19608861
K713 Methylation PhosphoSitePlus
K713 Ubiquitination PhosphoSitePlus
Y714 Phosphorylation PhosphoSitePlus
S715 Phosphorylation PhosphoSitePlus
S717 Phosphorylation PhosphoSitePlus
T722 O-Glycosylation GlyGen 23301498, 35008409, 33214551, ...30397120, 30379171, 34019948, 32119511, 28510447, 33465208
T722 Phosphorylation HPRD 20068231
K723 Ubiquitination PhosphoSitePlus
K734 Ubiquitination PhosphoSitePlus
S735 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
K736 Ubiquitination PhosphoSitePlus
K805 Ubiquitination PhosphoSitePlus
K806 Ubiquitination PhosphoSitePlus
K814 Ubiquitination PhosphoSitePlus
T841 Phosphorylation HPRD   PhosphoSitePlus 18452278
K874 Ubiquitination PhosphoSitePlus
K881 Ubiquitination PhosphoSitePlus
S882 O-Glycosylation GlyGen 23301498, 35008409, 33214551, ...30397120, 30379171, 34019948, 32119511, 28510447, 33465208
K903 Acetylation PhosphoSitePlus
K903 Ubiquitination PhosphoSitePlus
K910 Acetylation PhosphoSitePlus
K918 Ubiquitination PhosphoSitePlus
K934 Ubiquitination PhosphoSitePlus
K939 Ubiquitination PhosphoSitePlus
K944 Ubiquitination PhosphoSitePlus
T946 Phosphorylation PhosphoSitePlus
S951 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17525332, 18077418
S956 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 22067460, 18077418, 20068231, ...18452278
S957 Phosphorylation Q13535 (ATR) , Q13315 (ATM) HPRD   IntAct   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18452278, 17525332, 33627431, ...16618811, 11877377, 19629043, 15302935, 21388270, 22067460, 18669648, 19906707, 18077418, 19690332, 23186163, 14695167, 11877376, 29988990, 26673124, 30702968, 20068231
S962 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18669648, 15302935, ...20068231
S964 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S966 Phosphorylation Q13315 (ATM) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17525332, 33627431, 11877376, ...11877377, 21390062, 22099307, 18077418, 18452278, 9789013, 18669648, 19906707, 22977523, 21056556, 29988990, 26673124, 12447382, 21388270, 20068231, 14657349
S970 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 22067460, 18669648, 19691289, ...20068231
S971 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
Y973 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 22067460, 20068231
K1000 Ubiquitination PhosphoSitePlus
T1005 Phosphorylation PhosphoSitePlus
K1009 Ubiquitination PhosphoSitePlus
K1026 Ubiquitination PhosphoSitePlus
K1030 Ubiquitination PhosphoSitePlus
S1033 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
K1037 Ubiquitination PhosphoSitePlus
T1041 Phosphorylation PhosphoSitePlus
K1050 Ubiquitination PhosphoSitePlus
K1056 Ubiquitination PhosphoSitePlus
K1063 Ubiquitination PhosphoSitePlus
K1120 Ubiquitination PhosphoSitePlus
S1129 Phosphorylation PhosphoSitePlus
K1133 Methylation PhosphoSitePlus
K1196 Ubiquitination PhosphoSitePlus
C1210 Methylation IEDB 31844290
K1214 Ubiquitination PhosphoSitePlus
T1217 Phosphorylation PhosphoSitePlus
T1221 Phosphorylation PhosphoSitePlus
K1222 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T28 N28 Biomuta DOID:10283 / prostate cancer [ cosmic ]
R92 G92 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T182 A182 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K189 N189 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:4606 / bile duct cancer [ cosmic ]
K213 R213 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S318 F318 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R406 C406 Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:4362 / cervical cancer [ icgc ]
K475 M475 Biomuta DOID:3571 / liver cancer [ cosmic ]
K500 T500 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K536 R536 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K584 R584 Biomuta DOID:1324 / lung cancer [ cosmic ]
K637 M637 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K637 R637 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T644 I644 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R699 H699 Biomuta DOID:10283 / prostate cancer [ cosmic ]
R699 C699 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic ]
S703 F703 Biomuta [ cosmic ]
S703 P703 Biomuta DOID:363 / uterine cancer [ icgc ]
S703 Y703 Biomuta DOID:4159 / skin cancer [ cosmic ]
S715 Y715 Biomuta DOID:1324 / lung cancer [ cosmic ]
S882 * Biomuta DOID:263 / kidney cancer [ cosmic ]
K934 R934 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
T946 I946 Biomuta DOID:4159 / skin cancer [ cosmic ]
S956 I956 Biomuta DOID:4606 / bile duct cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S957 F957 Biomuta DOID:4159 / skin cancer [ cosmic ]
S966 T966 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
S971 G971 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y973 C973 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
K1120 E1120 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
S1129 L1129 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
K1133 N1133 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]