iPTMnet Report for Q14669 (TRIP12)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14669 / TRIPC_HUMAN
Protein Name E3 ubiquitin-protein ligase TRIP12
Gene Name Name: TRIP12
Synonyms:KIAA0045,ULF;
Organism Homo sapiens (Human)

PRO ID PR:Q14669
DAG View
PRO Name E3 ubiquitin-protein ligase TRIP12 (human)
Definition An E3 ubiquitin-protein ligase TRIP12 that is encoded in the genome of human.
Short Label hTRIP12
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14669 (TRIP12) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 21406692
S12 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
S34 Phosphorylation PhosphoSitePlus
S36 Phosphorylation PhosphoSitePlus
S75 Phosphorylation PhosphoSitePlus
S77 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983, 20068231
Y80 Phosphorylation PhosphoSitePlus
T83 Phosphorylation PhosphoSitePlus
S85 Phosphorylation PhosphoSitePlus
S87 Phosphorylation PhosphoSitePlus
S88 Phosphorylation PhosphoSitePlus
S100 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983
S109 Phosphorylation PhosphoSitePlus
K123 Methylation PhosphoSitePlus
K148 Acetylation PhosphoSitePlus
T152 Phosphorylation PhosphoSitePlus
S155 Phosphorylation PhosphoSitePlus
S159 Phosphorylation PhosphoSitePlus
S161 Phosphorylation PhosphoSitePlus
T192 Phosphorylation PhosphoSitePlus
T194 Phosphorylation PhosphoSitePlus
K223 Methylation PhosphoSitePlus
S238 Phosphorylation PhosphoSitePlus
S239 Phosphorylation PhosphoSitePlus
S241 Phosphorylation PhosphoSitePlus
K259 Ubiquitination PhosphoSitePlus
S267 Phosphorylation IEDB   PhosphoSitePlus 32387766, 27869121
K276 Ubiquitination PhosphoSitePlus
S278 Phosphorylation PhosphoSitePlus
S282 Phosphorylation PhosphoSitePlus
S283 Phosphorylation PhosphoSitePlus
S285 Phosphorylation PhosphoSitePlus
T287 Phosphorylation PhosphoSitePlus
S288 Phosphorylation PhosphoSitePlus
K289 Ubiquitination PhosphoSitePlus
K298 Acetylation PhosphoSitePlus
K298 Ubiquitination PhosphoSitePlus
K308 Methylation PhosphoSitePlus
S310 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 17081983
S312 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18220336, ...15302935, 18669648, 19690332, 20068231
S319 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
K327 Ubiquitination PhosphoSitePlus
T329 Phosphorylation PhosphoSitePlus
S331 Phosphorylation PhosphoSitePlus
S334 Phosphorylation PhosphoSitePlus
S340 Phosphorylation PhosphoSitePlus
K355 Ubiquitination PhosphoSitePlus
S361 Phosphorylation PhosphoSitePlus
S369 Phosphorylation PhosphoSitePlus
T387 Phosphorylation phospho.ELM 18669648
R422 Methylation PhosphoSitePlus
S424 Phosphorylation PhosphoSitePlus
Y507 Phosphorylation PhosphoSitePlus
S603 Phosphorylation IEDB 35494241
K617 Ubiquitination PhosphoSitePlus
T650 Phosphorylation PhosphoSitePlus
T748 Phosphorylation PhosphoSitePlus
K752 Ubiquitination PhosphoSitePlus
T758 O-Glycosylation GlyGen 36240223, 34725712, 28510447
T758 Phosphorylation PhosphoSitePlus
Y775 Phosphorylation PhosphoSitePlus
S780 Phosphorylation PhosphoSitePlus
T792 Phosphorylation PhosphoSitePlus
K799 Ubiquitination PhosphoSitePlus
Y811 Phosphorylation PhosphoSitePlus
K815 Ubiquitination PhosphoSitePlus
K825 Ubiquitination PhosphoSitePlus
K832 Ubiquitination PhosphoSitePlus
S936 Phosphorylation PhosphoSitePlus
T941 Phosphorylation PhosphoSitePlus
S942 Phosphorylation IEDB   PhosphoSitePlus   UniProt 23186163, 32387766, 20068231
S987 Phosphorylation PhosphoSitePlus
S991 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 16964243, ...19690332
S997 Phosphorylation IEDB   phospho.ELM   PhosphoSitePlus   UniProt 32387766, 18669648, 23186163
K1001 Ubiquitination PhosphoSitePlus
Y1015 Phosphorylation PhosphoSitePlus
S1016 Phosphorylation PhosphoSitePlus
K1029 Ubiquitination PhosphoSitePlus
S1030 Phosphorylation PhosphoSitePlus   UniProt 21406692
S1036 Phosphorylation PhosphoSitePlus
K1038 Ubiquitination PhosphoSitePlus
S1044 Phosphorylation PhosphoSitePlus
K1048 Ubiquitination PhosphoSitePlus
S1054 Phosphorylation PhosphoSitePlus
T1055 Phosphorylation PhosphoSitePlus
S1057 Phosphorylation PhosphoSitePlus
T1067 Phosphorylation PhosphoSitePlus
S1078 Phosphorylation O14757 (CHEK1) PhosphoSitePlus 21851590
K1079 Ubiquitination PhosphoSitePlus
S1113 Phosphorylation PhosphoSitePlus
Y1170 Phosphorylation PhosphoSitePlus
K1174 Ubiquitination PhosphoSitePlus
K1177 Ubiquitination PhosphoSitePlus
K1221 Ubiquitination PhosphoSitePlus
S1248 Phosphorylation PhosphoSitePlus
S1250 Phosphorylation PhosphoSitePlus
K1259 Ubiquitination PhosphoSitePlus
K1267 Ubiquitination PhosphoSitePlus
C1276 Methylation IEDB 31844290
K1280 Acetylation PhosphoSitePlus
K1280 Ubiquitination PhosphoSitePlus
K1283 Acetylation PhosphoSitePlus
K1288 Ubiquitination PhosphoSitePlus
S1317 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 18669648, ...24275569, 19690332
S1322 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 18669648, ...24275569, 19690332
S1329 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1367 Phosphorylation PhosphoSitePlus
R1374 Methylation PhosphoSitePlus
S1376 Phosphorylation PhosphoSitePlus
T1377 Phosphorylation PhosphoSitePlus
K1399 Ubiquitination PhosphoSitePlus
T1421 Phosphorylation PhosphoSitePlus
T1424 Phosphorylation PhosphoSitePlus
K1425 Ubiquitination PhosphoSitePlus
T1426 Phosphorylation PhosphoSitePlus
S1427 Phosphorylation PhosphoSitePlus
C1443 Methylation IEDB 31844290
K1507 Ubiquitination PhosphoSitePlus
S1575 Phosphorylation PhosphoSitePlus
S1577 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
T1592 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
K1600 Ubiquitination PhosphoSitePlus
K1661 Ubiquitination PhosphoSitePlus
S1663 Phosphorylation PhosphoSitePlus
K1668 Ubiquitination PhosphoSitePlus
K1686 Ubiquitination PhosphoSitePlus
K1692 Ubiquitination PhosphoSitePlus
K1702 Ubiquitination PhosphoSitePlus
K1706 Ubiquitination PhosphoSitePlus
K1724 Ubiquitination PhosphoSitePlus
K1766 Ubiquitination PhosphoSitePlus
K1809 Ubiquitination PhosphoSitePlus
K1877 Ubiquitination PhosphoSitePlus
T1937 Phosphorylation PhosphoSitePlus
K1941 Ubiquitination PhosphoSitePlus
T1942 Phosphorylation PhosphoSitePlus
S1955 Phosphorylation PhosphoSitePlus
K1977 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S77 Phosphorylation HPRD 19651622, 17081983, 20068231
S85 Phosphorylation HPRD 17924679
S88 Phosphorylation HPRD 17924679
T104 Phosphorylation HPRD 17081983
S109 Phosphorylation HPRD 20068231
S159 Phosphorylation HPRD 20068231
S310 Phosphorylation HPRD 19651622, 18669648, 18707149, ...19664995, 17081983
S312 Phosphorylation HPRD 19413330, 20058876, 19664994, ...15302935, 19664995, 18452278, 19651622, 18669648, 20068231
S319 Phosphorylation HPRD 17081983
S515 Phosphorylation HPRD 20068231
T758 Phosphorylation HPRD 20068231
S938 Phosphorylation HPRD 20068231
T941 Phosphorylation HPRD 20068231
S942 Phosphorylation HPRD 17322306, 20068231, 18452278
S991 Phosphorylation HPRD 19651622, 18669648, 18452278, ...19415658, 16964243
S997 Phosphorylation HPRD 18669648
Y1015 Phosphorylation HPRD 18452278
S1016 Phosphorylation HPRD 19651622, 18452278
S1317 Phosphorylation HPRD 19651622, 18669648, 18452278, ...19415658, 17081983
S1322 Phosphorylation HPRD 19651622, 18669648, 18452278, ...19415658, 17081983
S1329 Phosphorylation HPRD 18669648, 17081983
T1421 Phosphorylation HPRD 20068230
T1426 Phosphorylation HPRD 20068231, 20068230
S1427 Phosphorylation HPRD 17924679
T1529 Phosphorylation HPRD 20068231
T1532 Phosphorylation HPRD 20068231
S1577 Phosphorylation HPRD 17525332
T1592 Phosphorylation HPRD 17081983
Site PTM Type PTM Enzyme Score Source PMID
S45 Phosphorylation PhosphoSitePlus
S52 Phosphorylation PhosphoSitePlus
S54 Phosphorylation PhosphoSitePlus
R69 Methylation PhosphoSitePlus
S324 Phosphorylation PhosphoSitePlus
S325 Phosphorylation PhosphoSitePlus
T329 Phosphorylation PhosphoSitePlus
T1425 Phosphorylation PhosphoSitePlus
T1469 Phosphorylation PhosphoSitePlus
S1475 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 C2 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S34 I34 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S52 C52 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S54 F54 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S54 Y54 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R69 G69 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S85 Y85 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K148 R148 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S155 Y155 Biomuta DOID:363 / uterine cancer [ icgc ]
S155 F155 Biomuta DOID:4159 / skin cancer [ cosmic ]
S278 P278 Biomuta DOID:1324 / lung cancer [ cosmic ]
S282 P282 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S288 * Biomuta DOID:4362 / cervical cancer [ cosmic ]
S324 P324 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K327 * Biomuta DOID:3571 / liver cancer [ cosmic ]
K355 N355 Biomuta DOID:363 / uterine cancer [ icgc ]
S361 R361 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
R422 L422 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R422 Q422 Biomuta DOID:10283 / prostate cancer [ cosmic ]
R422 W422 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S515 F515 Biomuta DOID:4362 / cervical cancer [ cosmic ]
T650 I650 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T748 N748 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y775 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T941 I941 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y1015 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K1029 E1029 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
S1036 P1036 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1044 I1044 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
K1079 E1079 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K1174 E1174 Biomuta DOID:1324 / lung cancer [ cosmic ]
K1177 Q1177 Biomuta DOID:4362 / cervical cancer [ icgc ]
K1221 N1221 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1248 R1248 Biomuta DOID:363 / uterine cancer [ icgc ]
S1250 C1250 Biomuta DOID:3571 / liver cancer [ cosmic ]
K1259 T1259 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K1259 Q1259 Biomuta DOID:363 / uterine cancer [ icgc ]
K1283 N1283 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K1288 E1288 Biomuta DOID:363 / uterine cancer [ icgc ]
R1374 I1374 Biomuta DOID:363 / uterine cancer [ icgc ]
T1424 A1424 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
T1424 M1424 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S1427 F1427 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1475 F1475 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1663 I1663 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K1668 E1668 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T1942 M1942 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]