Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14653 / IRF3_HUMAN
Protein Name Interferon regulatory factor 3
Gene Name Name: IRF3
Organism Homo sapiens (Human)

PRO ID PR:Q14653
DAG View
PRO Name interferon regulatory factor 3 (human)
Definition An interferon regulatory factor 3 that is encoded in the genome of human.
Short Label hIRF3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14653 (IRF3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T3 Phosphorylation UniProt 23746807
S14 Phosphorylation PhosphoSitePlus   UniProt 23746807
K29 Ubiquitination PhosphoSitePlus
K70 Sumoylation PhosphoSitePlus
K70 Ubiquitination PhosphoSitePlus
T75 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 23746807, 27125670
K77 Ubiquitination PhosphoSitePlus
K87 Sumoylation PhosphoSitePlus
K87 Ubiquitination PhosphoSitePlus
S97 Phosphorylation RLIMS-P   UniProt 26692175, 23746807
S123 Phosphorylation PhosphoSitePlus
T135 Phosphorylation P78527 (PRKDC) neXtProt   PhosphoSitePlus   Signor 11867762
S173 Phosphorylation P45983 (MAPK8) , P45984 (MAPK9) , Q9UHD2 (TBK1) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 19153595, 20511230
S175 Phosphorylation Q9UHD2 (TBK1) neXtProt   PhosphoSitePlus   RLIMS-P 20511230, 24049179
T180 Phosphorylation PhosphoSitePlus   UniProt 23746807
S188 Phosphorylation PhosphoSitePlus   UniProt 23746807
K193 Ubiquitination PhosphoSitePlus
T237 Phosphorylation UniProt 23746807
T244 Phosphorylation UniProt 23746807
T253 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 27125670, 23746807
S259 Phosphorylation PhosphoSitePlus
K313 Ubiquitination PhosphoSitePlus
K315 Ubiquitination PhosphoSitePlus
S339 Phosphorylation PhosphoSitePlus   RLIMS-P 16699525
T370 Phosphorylation PhosphoSitePlus
S385 Phosphorylation Q9UHD2 (TBK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 17526488, 20511230, 25239187, ...10920266, 14703513, 9463386, 21347389, 22394562
S386 Phosphorylation Q14164 (IKBKE) , Q9UQM7 (CAMK2A) , Q9UHD2 (TBK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 17526488, 29800227, 31319869, ...28465426, 20511230, 14703513, 21347389, 26646986, 29962372, 25506707, 27454487, 24722368, 9463386, 23122814, 24173023, 20604809, 15919920, 20532218, 27045107, 28589097, 26216125, 20170763, 23746807, 18818394, 10920266, 24752990, 27302953, 26811330, 22394562
T390 Phosphorylation PhosphoSitePlus   RLIMS-P 20511230
S396 Phosphorylation O14920 (IKBKB) , Q14164 (IKBKE) , Q9UHD2 (TBK1) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 17526488, 28150813, 27791205, ...29800227, 29962372, 19893624, 12524442, 16306043, 21347389, 20035788, 20694008, 25444175, 19153595, 25923723, 20511230, 18356163, 24722368, 18272581, 25891802, 27576490, 20532218, 24549848, 25239187, 28589097, 27302953, 23633948, 16914100, 20170763, 24870145, 14739303, 23090018, 29677136, 23478265, 22396652, 16199137, 20161788, 26811330, 22394562, 31451663, 21138416
S398 Phosphorylation O14920 (IKBKB) , Q14164 (IKBKE) , Q9UHD2 (TBK1) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 23746807, 19153595, 17526488, ...23090018, 9566918, 16914100, 20604809
S402 Phosphorylation O14920 (IKBKB) , Q14164 (IKBKE) , Q9UHD2 (TBK1) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P 19153595, 17526488, 9566918, ...16914100, 18272581, 20604809, 20170763
T404 Phosphorylation Q9UHD2 (TBK1) , O14920 (IKBKB) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   UniProt 23746807, 19153595, 9566918, ...17526488
S405 Phosphorylation O14920 (IKBKB) , Q9UHD2 (TBK1) neXtProt   phospho.ELM   PRO   PhosphoSitePlus 19153595, 9566918, 17526488
S427 Phosphorylation UniProt 23746807
Site PTM Type PTM Enzyme Score Source PMID
S175 Phosphorylation HPRD 20166139
S339 Phosphorylation PRO
S385 Phosphorylation HPRD   PRO 10805757, 9463386
S386 Phosphorylation HPRD   PRO 10805757, 9463386
S396 Phosphorylation HPRD 12524442
S398 Phosphorylation HPRD   PRO 9566918
S402 Phosphorylation HPRD   PRO 9566918
T404 Phosphorylation HPRD   PRO 9566918
S405 Phosphorylation HPRD   PRO 9566918


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048048 (hIRF3/Phos:4) pS396,pS398,pS402,pT404,pS405 PRO
PR:000025763 (hIRF3/iso:1/Phos:1) pS385,pS386 PRO 10805757
PR:000045488 (hIRF3/Phos:1) pS386,pS398,pS402,pT404,pS405 PRO
PR:000045489 (hIRF3/iso:1/Phos:2) pS339,pS386,pS398,pS402,pT404,pS405 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q14653 (IRF3) S339 Q13526 (PIN1) unknown eFIP 16699525
Phosphorylation Q14653 (IRF3) S396 Q92793 (CREBBP) unknown eFIP 28589097


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000025763 (hIRF3/iso:1/Phos:1) Interaction PR:O14980 (hXPO1) PRO 10805757
PR:O14980 (hXPO1) Interaction PR:000025763 (hIRF3/iso:1/Phos:1) PRO 10805757


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T237 M237 Biomuta DOID:363 / uterine cancer [ tcga ]
T244 R244 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
T253 K253 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
T370 M370 Biomuta DOID:1612 / breast cancer [ tcga ] DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
T370 K370 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
T390 P390 Biomuta DOID:0070003 / blastoma [ cosmic ]
T390 I390 Biomuta DOID:363 / uterine cancer [ tcga ]
S427 T427 Biomuta DOID:9256 / colorectal cancer [ icgc ]