iPTMnet Report Q14653 IRF3

Protein Information

UniProt AC / UniProt ID	Q14653 / IRF3_HUMAN
Protein Name	Interferon regulatory factor 3
Gene Name	Name: IRF3
Organism	Homo sapiens (Human)

PRO ID	PR:Q14653 DAG View
PRO Name	interferon regulatory factor 3 (human)
Definition	An interferon regulatory factor 3 that is encoded in the genome of human.
Short Label	hIRF3
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q14653 (IRF3) as Substrate

Expanded View

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position T3 S14 K29 K39 K70 T75 K77 S82 K87 S97 K98 K105 S123 T135 S173 S175 T180 S188 K193 T207 T237 T244 T253 M258 S259 R285 Y292 K313 K315 S339 K366 T370 S385 S386 T390 S396 S398 S402 T404 S405 S427	PTM Type Select all Methylation Phosphorylation Sumoylation Ubiquitination	PTM Enzyme	Score Select all 1 2 3 4	Source Select all IEDB PRO PhosphoSitePlus RLIMS-P Signor UniProt neXtProt phospho.ELM	PMID
T3	Phosphorylation		score2	UniProt	23746807
S14	Phosphorylation		score3	PhosphoSitePlus UniProt	23746807
K29	Ubiquitination		score1	PhosphoSitePlus
K39	Ubiquitination		score1	PhosphoSitePlus
K70	Sumoylation		score1	PhosphoSitePlus
K70	Ubiquitination		score1	PhosphoSitePlus
T75	Phosphorylation		score4	PhosphoSitePlus RLIMS-P UniProt	23746807, 27125670
K77	Ubiquitination		score1	PhosphoSitePlus
S82	Phosphorylation		score3	PhosphoSitePlus RLIMS-P	35948267
K87	Sumoylation		score1	PhosphoSitePlus
K87	Ubiquitination		score1	PhosphoSitePlus
S97	Phosphorylation		score4	PhosphoSitePlus RLIMS-P UniProt	26692175, 23746807
K98	Ubiquitination		score1	PhosphoSitePlus
K105	Ubiquitination		score1	PhosphoSitePlus
S123	Phosphorylation		score1	PhosphoSitePlus
T135	Phosphorylation	P78527 (PRKDC)	score3	neXtProt PhosphoSitePlus Signor	11867762
S173	Phosphorylation	P45983 (MAPK8) , P45984 (MAPK9) , Q9UHD2 (TBK1)	score4	neXtProt PhosphoSitePlus RLIMS-P Signor	19153595, 20511230
S175	Phosphorylation	Q9UHD2 (TBK1)	score4	neXtProt PhosphoSitePlus RLIMS-P	20511230, 24049179
T180	Phosphorylation		score3	PhosphoSitePlus UniProt	23746807
S188	Phosphorylation		score3	PhosphoSitePlus UniProt	23746807
K193	Ubiquitination		score1	PhosphoSitePlus
T207	Phosphorylation		score3	PhosphoSitePlus RLIMS-P	35191555
T237	Phosphorylation		score2	UniProt	23746807
T244	Phosphorylation		score2	UniProt	23746807
T253	Phosphorylation		score4	PhosphoSitePlus RLIMS-P UniProt	27125670, 23746807
M258	Methylation		score1	IEDB	25880248
S259	Phosphorylation		score1	PhosphoSitePlus
R285	Methylation		score1	PhosphoSitePlus
Y292	Phosphorylation		score1	PhosphoSitePlus
K313	Ubiquitination		score1	PhosphoSitePlus
K315	Ubiquitination		score1	PhosphoSitePlus
S339	Phosphorylation		score3	PhosphoSitePlus RLIMS-P	16699525
K366	Methylation		score1	PhosphoSitePlus
T370	Phosphorylation		score1	PhosphoSitePlus
S385	Phosphorylation	Q9UHD2 (TBK1)	score4	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P UniProt	17526488, 20511230, 33205822, ...10920266, 14703513, 9463386, 21347389, 22394562
S386	Phosphorylation	Q14164 (IKBKE) , Q9UQM7 (CAMK2A) , Q9UHD2 (TBK1)	score4	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P UniProt	17526488, 29962372, 28465426, ...20511230, 14703513, 21347389, 26646986, 31319869, 25506707, 27454487, 24722368, 9463386, 20604809, 33300875, 20532218, 23746807, 27045107, 28589097, 26216125, 20170763, 28295920, 18818394, 33205822, 10920266, 24752990, 27302953, 26811330, 32161340, 22394562
T390	Phosphorylation		score3	PhosphoSitePlus RLIMS-P	20511230
S396	Phosphorylation	O14920 (IKBKB) , Q14164 (IKBKE) , Q9UHD2 (TBK1)	score4	neXtProt phospho.ELM PRO PhosphoSitePlus RLIMS-P UniProt	17526488, 28150813, 27791205, ...31618847, 29962372, 19893624, 12524442, 31686982, 21347389, 20694008, 16199137, 30867315, 32179480, 33986734, 19153595, 25923723, 23478265, 20416917, 20511230, 18356163, 33603735, 25444175, 33253291, 17761676, 25891802, 18272581, 33300875, 28717003, 33391252, 27576490, 20532218, 28589097, 27302953, 23633948, 16914100, 32634441, 20170763, 24870145, 14739303, 23090018, 20609418, 29677136, 30323286, 32783398, 20161788, 26811330, 24722368, 22394562, 21138416
S398	Phosphorylation	O14920 (IKBKB) , Q14164 (IKBKE) , Q9UHD2 (TBK1)	score4	neXtProt phospho.ELM PRO PhosphoSitePlus RLIMS-P UniProt	23746807, 19153595, 17526488, ...23090018, 9566918, 16914100, 20604809
S402	Phosphorylation	O14920 (IKBKB) , Q14164 (IKBKE) , Q9UHD2 (TBK1)	score4	neXtProt phospho.ELM PRO PhosphoSitePlus RLIMS-P	19153595, 17526488, 9566918, ...16914100, 18272581, 20604809, 20170763
T404	Phosphorylation	Q9UHD2 (TBK1) , O14920 (IKBKB)	score4	neXtProt phospho.ELM PRO PhosphoSitePlus UniProt	23746807, 19153595, 9566918, ...17526488
S405	Phosphorylation	O14920 (IKBKB) , Q9UHD2 (TBK1)	score4	neXtProt phospho.ELM PRO PhosphoSitePlus	19153595, 9566918, 17526488
S427	Phosphorylation		score2	UniProt	23746807

Search:

Site Select all By amino acid All Serine All Threonine By position S175 S339 S385 S386 S396 S398 S402 T404 S405	PTM Type Select all Phosphorylation	Score Select all 0 1 3 4	Source Select all HPRD PRO	PMID
S175	Phosphorylation	score0	HPRD	20166139
S339	Phosphorylation	score1	PRO
S385	Phosphorylation	score4	HPRD PRO	10805757, 9463386
S386	Phosphorylation	score4	HPRD PRO	10805757, 9463386
S396	Phosphorylation	score1	HPRD	12524442
S398	Phosphorylation	score3	HPRD PRO	9566918
S402	Phosphorylation	score3	HPRD PRO	9566918
T404	Phosphorylation	score3	HPRD PRO	9566918
S405	Phosphorylation	score3	HPRD PRO	9566918

Proteoforms

Search:

PRO ID (Short Label) Select all PR:000025763 (hIRF3/iso:1/Phos:1) PR:000045488 (hIRF3/Phos:1) PR:000045489 (hIRF3/iso:1/Phos:2) PR:000048048 (hIRF3/Phos:4)	Sites Select all pS339,pS386,pS398,pS402,pT404,pS405 pS385,pS386 pS386,pS398,pS402,pT404,pS405 pS396,pS398,pS402,pT404,pS405	Source Select all PRO	PMID
PR:000048048 (hIRF3/Phos:4)	pS396,pS398,pS402,pT404,pS405	PRO
PR:000025763 (hIRF3/iso:1/Phos:1)	pS385,pS386	PRO	10805757
PR:000045488 (hIRF3/Phos:1)	pS386,pS398,pS402,pT404,pS405	PRO
PR:000045489 (hIRF3/iso:1/Phos:2)	pS339,pS386,pS398,pS402,pT404,pS405	PRO

PTM-dependent PPI

Search:

PTM type Select all Phosphorylation	Substrate Select all Q14653 (IRF3) Q86WV6 (STING1)	Site Select all By amino acid All Serine By position S339 S366 S396	Interactant Select all Q13526 (PIN1) Q14653 (IRF3) Q92793 (CREBBP)	Association type Select all inhibited_association unknown	Source Select all eFIP	PMID
Phosphorylation	Q14653 (IRF3)	S396	Q92793 (CREBBP)	unknown	eFIP	28589097
Phosphorylation	Q14653 (IRF3)	S339	Q13526 (PIN1)	unknown	eFIP	16699525
Phosphorylation	Q86WV6 (STING1)	S366	Q14653 (IRF3)	inhibited_association	eFIP	25254379

Proteoform PPIs

Search:

	Protein 1 Select all PR:000025763 (hIRF3/iso:1/Phos:1) PR:O14980 (hXPO1)	Relation Select all Interaction	Protein 2 Select all PR:000025763 (hIRF3/iso:1/Phos:1) PR:O14980 (hXPO1)	Source Select all PRO	PMID
	PR:000025763 (hIRF3/iso:1/Phos:1)	Interaction	PR:O14980 (hXPO1)	PRO	10805757
	PR:O14980 (hXPO1)	Interaction	PR:000025763 (hIRF3/iso:1/Phos:1)	PRO	10805757

PTM sites affected in variants

Search:

Site Select all By amino acid All Serine All Threonine By position K29 S82 T237 T244 T253 R285 K366 T370 T390 S427	Variant Select all I390 K253 K370 L285 M237 M370 N29 P390 R244 R366 T427 W285 Y82	Source Select all Biomuta	Disease [Sample source] Select all DOID:11054 / urinary bladder cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] DOID:3571 / liver cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:363 / uterine cancer [ icgc ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ icgc ] [ cosmic ]
K29	N29	Biomuta	[ cosmic ]
S82	Y82	Biomuta	DOID:363 / uterine cancer [ icgc ]
T237	M237	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
T244	R244	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
T253	K253	Biomuta	DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R285	W285	Biomuta	DOID:8618 / oral cavity cancer [ cosmic ]
R285	L285	Biomuta	DOID:1324 / lung cancer [ cosmic ]
K366	R366	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
T370	M370	Biomuta	DOID:1612 / breast cancer [ cosmic, icgc ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T370	K370	Biomuta	DOID:3571 / liver cancer [ cosmic ]
T390	P390	Biomuta	DOID:3571 / liver cancer [ cosmic ]
T390	I390	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
S427	T427	Biomuta	DOID:9256 / colorectal cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ icgc ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for Q14653 (IRF3)

Protein Information

Interactive Sequence View

Q14653 (IRF3) as Substrate

Proteoforms

PTM-dependent PPI

Proteoform PPIs

PTM sites affected in variants