Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14651 / PLSI_HUMAN
Protein Name Plastin-1
Gene Name Name: PLS1
Organism Homo sapiens (Human)

PRO ID PR:Q14651
DAG View
PRO Name plastin-1 (human)
Definition A plastin-1 that is encoded in the genome of human.
Short Label hPLS1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14651 (PLS1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
S32 Phosphorylation PhosphoSitePlus
K58 Ubiquitination PhosphoSitePlus
S78 Phosphorylation PhosphoSitePlus
R93 Methylation PhosphoSitePlus
T103 Phosphorylation PhosphoSitePlus
S121 Phosphorylation PhosphoSitePlus
S172 Phosphorylation PhosphoSitePlus
Y301 Phosphorylation PhosphoSitePlus
K333 Acetylation PhosphoSitePlus
K333 Ubiquitination PhosphoSitePlus
T352 Phosphorylation PhosphoSitePlus
S358 Phosphorylation PhosphoSitePlus
Y431 Phosphorylation PhosphoSitePlus
K456 Acetylation PhosphoSitePlus
K457 Acetylation PhosphoSitePlus
K457 Ubiquitination PhosphoSitePlus
S509 Phosphorylation PhosphoSitePlus
K531 Ubiquitination PhosphoSitePlus
S541 Phosphorylation PhosphoSitePlus
K585 Ubiquitination PhosphoSitePlus
K593 Ubiquitination PhosphoSitePlus
Y599 Phosphorylation PhosphoSitePlus
T615 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
M1 I1 Biomuta DOID:1909 / melanoma [ tcga ] DOID:3571 / liver cancer [ icgc ]
S78 L78 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
R93 * Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S121 L121 Biomuta DOID:1909 / melanoma [ icgc ] DOID:1324 / lung cancer [ tcga ]
S172 F172 Biomuta DOID:1909 / melanoma [ tcga ]
Y431 H431 Biomuta DOID:363 / uterine cancer [ tcga ]
Y431 C431 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
K457 R457 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
S509 L509 Biomuta DOID:5041 / esophageal cancer [ icgc ]
Y599 C599 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
T615 M615 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]