iPTMnet Report for Q14642 (INPP5A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14642 / I5P1_HUMAN
Protein Name Inositol polyphosphate-5-phosphatase A precursor
Gene Name Name: INPP5A
Synonyms:5PTASE;
Organism Homo sapiens (Human)

PRO ID PR:Q14642
DAG View
PRO Name inositol polyphosphate-5-phosphatase A (human)
Definition An inositol polyphosphate-5-phosphatase A that is encoded in the genome of human.
Short Label hINPP5A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14642 (INPP5A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K45 Acetylation PhosphoSitePlus
K73 Ubiquitination PhosphoSitePlus
K82 Ubiquitination PhosphoSitePlus
S137 Phosphorylation PhosphoSitePlus
T143 Phosphorylation PhosphoSitePlus
K249 Ubiquitination PhosphoSitePlus
K265 Ubiquitination PhosphoSitePlus
K284 Ubiquitination PhosphoSitePlus
K307 Ubiquitination PhosphoSitePlus
K358 Ubiquitination PhosphoSitePlus
K400 Methylation PhosphoSitePlus
K407 Methylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K45 R45 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic, icgc ]
T143 M143 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]
K265 T265 Biomuta DOID:3571 / liver cancer [ cosmic ]
K358 M358 Biomuta DOID:4606 / bile duct cancer [ cosmic ]