Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14573 / ITPR3_HUMAN
Protein Name Inositol 1,4,5-trisphosphate receptor type 3
Gene Name Name: ITPR3
Organism Homo sapiens (Human)

PRO ID PR:Q14573
DAG View
PRO Name inositol 1,4,5-trisphosphate receptor type 3 (human)
Definition An inositol 1,4,5-trisphosphate receptor type 3 that is encoded in the genome of human.
Short Label hITPR3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14573 (ITPR3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K69 Ubiquitination PhosphoSitePlus
K83 Ubiquitination PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
S120 Phosphorylation PhosphoSitePlus
K131 Ubiquitination PhosphoSitePlus
Y132 Phosphorylation PhosphoSitePlus
T134 Phosphorylation PhosphoSitePlus
K137 Ubiquitination PhosphoSitePlus
K145 Ubiquitination PhosphoSitePlus
K208 Ubiquitination PhosphoSitePlus
K236 Ubiquitination PhosphoSitePlus
K250 Acetylation PhosphoSitePlus
K250 Ubiquitination PhosphoSitePlus
Y257 Phosphorylation PhosphoSitePlus
K324 Ubiquitination PhosphoSitePlus
K331 Ubiquitination PhosphoSitePlus
S385 Phosphorylation PhosphoSitePlus
K426 Ubiquitination PhosphoSitePlus
S484 Phosphorylation PhosphoSitePlus
K529 Ubiquitination PhosphoSitePlus
K545 Ubiquitination PhosphoSitePlus
K608 Ubiquitination PhosphoSitePlus
T613 Phosphorylation PhosphoSitePlus
K706 Ubiquitination PhosphoSitePlus
T795 Phosphorylation PhosphoSitePlus
K813 Ubiquitination PhosphoSitePlus
Y905 Phosphorylation PhosphoSitePlus
S916 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S930 Phosphorylation PhosphoSitePlus
K932 Ubiquitination PhosphoSitePlus
S934 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 18578522
S937 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18578522, 18669648, 20068231
S940 Phosphorylation PhosphoSitePlus
S942 Phosphorylation HPRD   PhosphoSitePlus 18578522
S954 Phosphorylation PhosphoSitePlus
Y989 Phosphorylation PhosphoSitePlus
K1111 Ubiquitination PhosphoSitePlus
K1164 Ubiquitination PhosphoSitePlus
Y1169 Phosphorylation PhosphoSitePlus
K1173 Ubiquitination PhosphoSitePlus
K1181 Ubiquitination PhosphoSitePlus
K1216 Ubiquitination PhosphoSitePlus
Y1299 Phosphorylation PhosphoSitePlus
Y1382 Phosphorylation PhosphoSitePlus
S1567 Phosphorylation PhosphoSitePlus
S1568 Phosphorylation PhosphoSitePlus
T1572 Phosphorylation PhosphoSitePlus
K1589 Ubiquitination PhosphoSitePlus
K1652 Ubiquitination PhosphoSitePlus
K1735 Ubiquitination PhosphoSitePlus
S1782 Phosphorylation PhosphoSitePlus
S1813 Phosphorylation PhosphoSitePlus   UniProt 19690332
K1827 Ubiquitination PhosphoSitePlus
S1832 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18578522, 23186163, 20058876, ...19691289, 18669648, 24275569
S1834 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18578522, 23186163
S1838 Phosphorylation PhosphoSitePlus
S1839 Phosphorylation PhosphoSitePlus
S1840 Phosphorylation PhosphoSitePlus
S1843 Phosphorylation HPRD   PhosphoSitePlus 18578522
S1847 Phosphorylation PhosphoSitePlus
S1861 Phosphorylation PhosphoSitePlus
S1997 Phosphorylation PhosphoSitePlus
K1998 Ubiquitination PhosphoSitePlus
K2030 Ubiquitination PhosphoSitePlus
K2031 Ubiquitination PhosphoSitePlus
S2045 Phosphorylation PhosphoSitePlus
K2072 Ubiquitination PhosphoSitePlus
S2090 Phosphorylation PhosphoSitePlus
K2094 Ubiquitination PhosphoSitePlus
K2101 Ubiquitination PhosphoSitePlus
K2152 Ubiquitination PhosphoSitePlus
K2167 Ubiquitination PhosphoSitePlus
T2306 Phosphorylation PhosphoSitePlus
K2360 Ubiquitination PhosphoSitePlus
K2535 Ubiquitination PhosphoSitePlus
K2578 Ubiquitination PhosphoSitePlus
K2595 Ubiquitination PhosphoSitePlus
K2597 Ubiquitination PhosphoSitePlus
S2609 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 18452278
K2628 Ubiquitination PhosphoSitePlus
K2634 Ubiquitination PhosphoSitePlus
K2647 Ubiquitination PhosphoSitePlus
S2670 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18578522, 23186163, 17081983, ...18767875, 19664994, 18669648, 20068231


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O43865 (AHCYL1) S71 Q14573 (ITPR3) unknown eFIP 27995898
Phosphorylation P40763 (STAT3) Y705 Q14573 (ITPR3) unknown eFIP 30042492


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S385 L385 Biomuta DOID:9256 / colorectal cancer [ tcga ]
K545 R545 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
K608 N608 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
K706 N706 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S916 F916 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S934 T934 Biomuta DOID:4362 / cervical cancer [ tcga ]
S942 C942 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y1382 C1382 Biomuta DOID:2394 / ovarian cancer [ tcga ]
Y1382 F1382 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
S1567 F1567 Biomuta DOID:1909 / melanoma [ cosmic ]
S1568 R1568 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S1568 T1568 Biomuta DOID:1612 / breast cancer [ cosmic ]
S1839 * Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
K2595 N2595 Biomuta DOID:3571 / liver cancer [ icgc ]
K2628 T2628 Biomuta DOID:1612 / breast cancer [ icgc ]