iPTMnet Report for Q14524 (SCN5A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14524 / SCN5A_HUMAN
Protein Name Sodium channel protein type 5 subunit alpha
Gene Name Name: SCN5A
Organism Homo sapiens (Human)

PRO ID PR:Q14524
DAG View
PRO Name sodium channel protein type 5 subunit alpha (human)
Definition A sodium channel protein type 5 subunit alpha that is encoded in the genome of human.
Short Label hSCN5A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14524 (SCN5A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S11 Phosphorylation PhosphoSitePlus
S12 Phosphorylation PhosphoSitePlus
T17 Phosphorylation PhosphoSitePlus
S20 Phosphorylation PhosphoSitePlus
S36 Phosphorylation UniProt 23092124
T38 Phosphorylation UniProt 23092124
S42 Phosphorylation PhosphoSitePlus
S61 Phosphorylation PhosphoSitePlus
Y68 Phosphorylation RLIMS-P 29734505
T101 Phosphorylation PhosphoSitePlus
S231 Phosphorylation PhosphoSitePlus
K343 Acetylation PhosphoSitePlus
K442 Sumoylation PhosphoSitePlus
T455 Phosphorylation PhosphoSitePlus
S457 Phosphorylation PhosphoSitePlus   UniProt 23092124
S459 Phosphorylation PhosphoSitePlus
S460 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 23092124, 33828490
S464 Phosphorylation PhosphoSitePlus
S471 Phosphorylation PhosphoSitePlus
S476 Phosphorylation PhosphoSitePlus
S483 Phosphorylation PhosphoSitePlus   UniProt 23092124
S484 Phosphorylation PhosphoSitePlus   UniProt 23092124
T486 Phosphorylation PhosphoSitePlus
S497 Phosphorylation PhosphoSitePlus   UniProt 23092124
S499 Phosphorylation PhosphoSitePlus
S510 Phosphorylation PhosphoSitePlus   UniProt 23092124
R513 Methylation PhosphoSitePlus   UniProt 21726068
S516 Phosphorylation Q13557 (CAMK2D) neXtProt   PhosphoSitePlus   Signor 22514276
S519 Phosphorylation PhosphoSitePlus
S524 Phosphorylation PhosphoSitePlus
S525 Phosphorylation PhosphoSitePlus
R526 Methylation PhosphoSitePlus   UniProt 21726068
S528 Phosphorylation PhosphoSitePlus
T531 Phosphorylation PhosphoSitePlus
S539 Phosphorylation PhosphoSitePlus
T570 Phosphorylation PhosphoSitePlus
S571 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 24812278, 23092124
S577 Phosphorylation PhosphoSitePlus
K590 Ubiquitination PhosphoSitePlus
T594 Phosphorylation Q13557 (CAMK2D) neXtProt   PhosphoSitePlus   Signor 22514276
S664 Phosphorylation PhosphoSitePlus   UniProt 23092124
S667 Phosphorylation PhosphoSitePlus   UniProt 23092124
T670 Phosphorylation PhosphoSitePlus
S671 Phosphorylation PhosphoSitePlus
R680 Methylation UniProt 21726068
Y694 Phosphorylation PhosphoSitePlus
S1003 Phosphorylation PhosphoSitePlus
T1094 Phosphorylation PhosphoSitePlus
S1099 O-Glycosylation GlyGen 29530619, 29351928
S1103 Phosphorylation PhosphoSitePlus
S1104 Phosphorylation PhosphoSitePlus
K1479 Acetylation PhosphoSitePlus
K1493 Acetylation PhosphoSitePlus
Y1494 Phosphorylation P06241 (FYN) phospho.ELM   PhosphoSitePlus 15831816
Y1495 Phosphorylation P06241 (FYN) phospho.ELM   PhosphoSitePlus   Signor 15831816
S1503 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 19666841
S1865 Phosphorylation PhosphoSitePlus
S1885 Phosphorylation PhosphoSitePlus
T1895 Phosphorylation PhosphoSitePlus
S1920 Phosphorylation PhosphoSitePlus
S1925 Phosphorylation PhosphoSitePlus
S1934 Phosphorylation PhosphoSitePlus
S1937 Phosphorylation PhosphoSitePlus
S1985 Phosphorylation PhosphoSitePlus
S1998 Phosphorylation PhosphoSitePlus
S2007 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S36 L36 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S42 I42 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T101 A101 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K343 N343 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K343 E343 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S457 T457 Biomuta DOID:10534 / stomach cancer [ icgc ]
S460 F460 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S471 G471 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S471 I471 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S476 G476 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S484 L484 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:4606 / bile duct cancer [ cosmic ]
S484 P484 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S497 Y497 Biomuta DOID:1324 / lung cancer [ cosmic ]
S510 N510 Biomuta DOID:4159 / skin cancer [ cosmic ]
S510 G510 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
R513 H513 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
S525 R525 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
R526 C526 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
R526 H526 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S528 N528 Biomuta DOID:4159 / skin cancer [ cosmic ]
T531 P531 Biomuta DOID:1612 / breast cancer [ cosmic ]
S577 G577 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R680 H680 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
S1104 Y1104 Biomuta DOID:1324 / lung cancer [ cosmic ]
K1479 T1479 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K1479 N1479 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S1865 F1865 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S1985 G1985 Biomuta DOID:363 / uterine cancer [ icgc ]