iPTMnet Report for Q14511 (NEDD9)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14511 / CASL_HUMAN
Protein Name Enhancer of filamentation 1
Gene Name Name: NEDD9
Synonyms:CASL;
Organism Homo sapiens (Human)

PRO ID PR:Q14511
DAG View
PRO Name enhancer of filamentation 1 (human)
Definition An enhancer of filamentation 1 that is encoded in the genome of human.
Short Label hNEDD9
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14511 (NEDD9) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y12 Phosphorylation phospho.ELM   PhosphoSitePlus 15144186
S47 Phosphorylation IntAct 22609948
Y92 Phosphorylation PhosphoSitePlus   UniProt 22810897
T104 O-Glycosylation GlyGen 29485866, 29351928
T104 Phosphorylation PhosphoSitePlus
Y106 Phosphorylation PhosphoSitePlus
S111 Phosphorylation PhosphoSitePlus
Y112 Phosphorylation PhosphoSitePlus
Y118 Phosphorylation PhosphoSitePlus
T122 Phosphorylation PhosphoSitePlus
T126 Phosphorylation PhosphoSitePlus
Y132 Phosphorylation PhosphoSitePlus
T160 Phosphorylation PhosphoSitePlus
Y164 Phosphorylation PhosphoSitePlus   UniProt 22810897
Y166 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 12522270, 22810897
Y168 Phosphorylation PhosphoSitePlus
Y172 Phosphorylation PhosphoSitePlus
Y177 Phosphorylation PhosphoSitePlus   UniProt 22810897
S182 Phosphorylation PhosphoSitePlus
T184 Phosphorylation PhosphoSitePlus
T185 Phosphorylation PhosphoSitePlus
Y189 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 23874939, 22810897
Y214 Phosphorylation PhosphoSitePlus   UniProt 22810897
T219 Phosphorylation PhosphoSitePlus
Y223 Phosphorylation PhosphoSitePlus   UniProt 22810897
S228 Phosphorylation PhosphoSitePlus
Y241 Phosphorylation PhosphoSitePlus
Y261 Phosphorylation PhosphoSitePlus
Y279 Phosphorylation UniProt 22810897
S296 Phosphorylation O14965 (AURKA) neXtProt   PhosphoSitePlus   Signor   UniProt 16184168, 19539609
S298 Phosphorylation PhosphoSitePlus
S309 Phosphorylation PhosphoSitePlus
S312 Phosphorylation PhosphoSitePlus
Y317 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18083107, 22810897
S333 Phosphorylation PhosphoSitePlus
Y345 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
S369 Phosphorylation PhosphoSitePlus   UniProt 19539609
K388 Ubiquitination PhosphoSitePlus
S395 Phosphorylation PhosphoSitePlus
K400 Ubiquitination PhosphoSitePlus
C437 Methylation IEDB 31844290
S510 Phosphorylation IntAct 22609948
T546 Phosphorylation IntAct 22609948
T548 Phosphorylation IntAct 22609948
T551 Phosphorylation IntAct 22609948
S563 Phosphorylation PhosphoSitePlus
S576 Phosphorylation PhosphoSitePlus
S616 Phosphorylation IntAct   PhosphoSitePlus 22609948
S617 Phosphorylation PhosphoSitePlus
S618 Phosphorylation PhosphoSitePlus
S621 Phosphorylation PhosphoSitePlus
Y629 Phosphorylation PhosphoSitePlus
Y631 Phosphorylation PhosphoSitePlus
K650 Ubiquitination PhosphoSitePlus
S692 Phosphorylation PhosphoSitePlus
K775 Ubiquitination PhosphoSitePlus
S780 Phosphorylation IntAct   PhosphoSitePlus   RLIMS-P   UniProt 29191835, 22609948
T804 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 29191835
Site PTM Type PTM Enzyme Score Source PMID
Y92 Phosphorylation HPRD 12522270
Y164 Phosphorylation HPRD 16497976
Y166 Phosphorylation HPRD 12522270, 15144186, 16497976
Y168 Phosphorylation HPRD 16497976
Y177 Phosphorylation HPRD 12522270
Y189 Phosphorylation HPRD 12522270
Y317 Phosphorylation HPRD 18083107
Y345 Phosphorylation HPRD 18083107
Site PTM Type PTM Enzyme Score Source PMID
Y92 Phosphorylation HPRD 12522270


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q14511 (NEDD9) S780 P53350 (PLK1) increased_association eFIP 29191835


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y92 C92 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, cosmic, icgc ]
Y112 N112 Biomuta DOID:363 / uterine cancer [ cosmic ]
S228 C228 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S298 F298 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S395 F395 Biomuta DOID:3571 / liver cancer [ cosmic ]
T546 I546 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T548 S548 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
S576 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y631 C631 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T804 I804 Biomuta DOID:4159 / skin cancer [ cosmic ]