iPTMnet Report for Q14494 (NFE2L1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14494 / NF2L1_HUMAN
Protein Name Endoplasmic reticulum membrane sensor NFE2L1
Gene Name Name: NFE2L1
Synonyms:HBZ17,NRF1,TCF11;
Organism Homo sapiens (Human)

PRO ID PR:Q14494
DAG View
PRO Name endoplasmic reticulum membrane sensor NFE2L1 (human)
Definition An endoplasmic reticulum membrane sensor NFE2L1 that is encoded in the genome of human.
Short Label hNFE2L1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14494 (NFE2L1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S3 Phosphorylation PhosphoSitePlus
K70 Ubiquitination PhosphoSitePlus
K199 Ubiquitination PhosphoSitePlus
K205 Ubiquitination PhosphoSitePlus
C256 Methylation IEDB 31844290
C264 Methylation IEDB 31844290
S285 Phosphorylation PhosphoSitePlus
S379 Phosphorylation P49841 (GSK3B) PhosphoSitePlus   Signor 23623971
S498 Phosphorylation PhosphoSitePlus
S499 Phosphorylation PhosphoSitePlus
S500 Phosphorylation PhosphoSitePlus
S501 Phosphorylation PhosphoSitePlus
S502 Phosphorylation PhosphoSitePlus
C564 Methylation IEDB 31844290
S599 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15308669
K609 Ubiquitination PhosphoSitePlus
K622 Ubiquitination PhosphoSitePlus
K629 Ubiquitination PhosphoSitePlus
S643 Phosphorylation PhosphoSitePlus
K644 Methylation IEDB 25880248
K675 Ubiquitination PhosphoSitePlus
K693 Ubiquitination PhosphoSitePlus
K700 Ubiquitination PhosphoSitePlus
K713 Ubiquitination PhosphoSitePlus
S734 Phosphorylation IEDB   PhosphoSitePlus 30784271
Y738 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y645 Phosphorylation HPRD 17693683


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S499 P499 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S501 F501 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S643 F643 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K713 T713 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K713 N713 Biomuta DOID:3571 / liver cancer [ cosmic ]