iPTMnet Report for Q14469 (HES1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14469 / HES1_HUMAN
Protein Name Transcription factor HES-1
Gene Name Name: HES1
Synonyms:BHLHB39,HL,HRY;
Organism Homo sapiens (Human)

PRO ID PR:Q14469
DAG View
PRO Name transcription factor HES-1 (human)
Definition A transcription factor HES-1 that is encoded in the genome of human.
Short Label hHES1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14469 (HES1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S10 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P 19413330, 21402701
S11 Phosphorylation PhosphoSitePlus
S12 Phosphorylation PhosphoSitePlus
T24 Phosphorylation HPRD   PhosphoSitePlus 19413330
S32 Phosphorylation PhosphoSitePlus
S37 Phosphorylation P17252 (PRKCA) HPRD   phospho.ELM   PhosphoSitePlus 9389649
S38 Phosphorylation P17252 (PRKCA) HPRD   phospho.ELM   PhosphoSitePlus 9389649
S55 O-Glycosylation GlyGen 30379171
S55 Phosphorylation PhosphoSitePlus
T59 Phosphorylation PhosphoSitePlus
K77 Ubiquitination PhosphoSitePlus
T84 O-Glycosylation GlyGen 30379171
K86 Ubiquitination PhosphoSitePlus
T97 Phosphorylation PhosphoSitePlus
K109 Methylation IEDB 32357974
K109 Ubiquitination PhosphoSitePlus
C146 Methylation IEDB 31844290


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S11 L11 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S11 W11 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S38 * Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
T84 K84 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
T84 I84 Biomuta DOID:1324 / lung cancer [ cosmic ]