iPTMnet Report for Q14457 (BECN1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14457 / BECN1_HUMAN
Protein Name Beclin-1
Gene Name Name: BECN1
Synonyms:GT197;
Organism Homo sapiens (Human)

PRO ID PR:Q14457
DAG View
PRO Name beclin-1 (human)
Definition A beclin-1 that is encoded in the genome of human.
Short Label hBECN1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14457 (BECN1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Ubiquitination PRO
M1 Acetylation UniProt 22814378
S15 Phosphorylation PRO   PhosphoSitePlus   RLIMS-P   UniProt 27817185, 31123703, 28691313, ...27696537
K26 Ubiquitination PhosphoSitePlus
S30 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 23186163, 29313410, 28486006, ...28238651
K32 Ubiquitination PhosphoSitePlus
T38 Phosphorylation HPRD   PhosphoSitePlus 20068231
K53 Ubiquitination PhosphoSitePlus
T57 Phosphorylation HPRD   PhosphoSitePlus 18691976
T62 Phosphorylation HPRD 18691976
S64 Phosphorylation HPRD   PhosphoSitePlus 18691976
S90 Phosphorylation P49137 (MAPKAPK2) , Q6J9G0 (STYK1) , Q16644 (MAPKAPK3) , O96017 (CHEK2) PhosphoSitePlus   RLIMS-P   Signor   UniProt 28085066, 32187724, 23878393, ...25693418, 31696776, 31399521, 29079782
T91 Phosphorylation PhosphoSitePlus   RLIMS-P 27618775
S93 Phosphorylation O96017 (CHEK2) PhosphoSitePlus   RLIMS-P   Signor   UniProt 27618775, 36410674, 32187724, ...25356873, 23878393, 25891078, 36192481, 27696537, 30767700, 28299793
S96 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 25891078, 25356873, 30767700, ...27618775
T108 Phosphorylation Q13043 (STK4) PhosphoSitePlus   RLIMS-P 24141421
K117 Ubiquitination PhosphoSitePlus
T119 Phosphorylation P53355 (DAPK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19395874, 29717115, 31601785, ...19180116, 33561998
T141 Phosphorylation RLIMS-P 27618775
K203 Ubiquitination PhosphoSitePlus
K206 Acetylation PhosphoSitePlus
K214 Ubiquitination PhosphoSitePlus
Y229 Phosphorylation P00533 (EGFR) PhosphoSitePlus 24034250
Y233 Phosphorylation P00533 (EGFR) PRO   PhosphoSitePlus   RLIMS-P 31399521, 27994061, 24034250
S234 Phosphorylation PhosphoSitePlus   RLIMS-P 27618775
K237 Ubiquitination PhosphoSitePlus
K248 Ubiquitination PhosphoSitePlus
K263 Ubiquitination PhosphoSitePlus
S279 Phosphorylation PhosphoSitePlus
S295 Phosphorylation P31749 (AKT1) PhosphoSitePlus   RLIMS-P 27245989, 27715386, 23112296, ...36271983
K324 Ubiquitination PhosphoSitePlus
Y333 Phosphorylation PhosphoSitePlus   RLIMS-P 34131122
S337 Phosphorylation PhosphoSitePlus
Y352 Phosphorylation P00533 (EGFR) PhosphoSitePlus   RLIMS-P 31399521, 24034250
T388 Phosphorylation PhosphoSitePlus   RLIMS-P 27304906
K402 Ubiquitination PhosphoSitePlus   UniProt 28445460
T406 Phosphorylation P78368 (CSNK1G2) PhosphoSitePlus 26008601
S409 Phosphorylation P78368 (CSNK1G2) PhosphoSitePlus 26008601
K427 Ubiquitination PhosphoSitePlus
K430 Acetylation PhosphoSitePlus
K437 Acetylation PhosphoSitePlus
K437 Ubiquitination PhosphoSitePlus   UniProt 23974797
Site PTM Type PTM Enzyme Score Source PMID
T119 Phosphorylation PR:000029896 (DAPK[1/2/3]) PRO 19180116, 19395874


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000046478 (hBECN1/Phos:2) pS15 PRO
PR:000046479 (hBECN1/UbiqLys+) ub PRO
PR:000049932 (hBECN1/Phos:3) pY233 PRO 27994061
PR:000027471 (hBECN1/iso:1/Phos:1) pT119 PR:000029896 (DAPK[1/2/3]) PRO 19180116, 19395874


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P10415 (BCL2) S70 Q14457 (BECN1) unknown eFIP 35013120
Phosphorylation P10415 (BCL2) S70 Q14457 (BECN1) unknown eFIP 29433359
Phosphorylation P10415 (BCL2) S70 Q14457 (BECN1) unknown eFIP 32097085
Phosphorylation P63244 (RACK1) T50 Q14457 (BECN1) unknown eFIP 26549445
Phosphorylation Q14457 (BECN1) S93 P54646 (PRKAA2) unknown eFIP 25356873
Phosphorylation Q14457 (BECN1) T119 P10415 (BCL2) decreased_association eFIP 19395874
Phosphorylation Q14457 (BECN1) T119 Q07817 (BCL2L1) increased_association eFIP 29717115
Phosphorylation Q14457 (BECN1) S295 P10415 (BCL2) unknown eFIP 27245989
Phosphorylation Q8NEB9 (PIK3C3) T159 Q14457 (BECN1) inhibited_association eFIP 20513426


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000027463 (hBCL2/iso:1/Phos:3) NOT Interaction PR:Q14457 (hBECN1) PRO 18570871, 19029119
PR:000027471 (hBECN1/iso:1/Phos:1) decreased Interaction PR:P10415 (hBCL2) PRO 19395874
PR:000027471 (hBECN1/iso:1/Phos:1) decreased Interaction PR:Q07817-1 (hBCL2L1/iso:1) PRO 19180116


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K206 N206 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]