iPTMnet Report for Q14451 (GRB7)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14451 / GRB7_HUMAN
Protein Name Growth factor receptor-bound protein 7
Gene Name Name: GRB7
Organism Homo sapiens (Human)

PRO ID PR:Q14451
DAG View
PRO Name growth factor receptor-bound protein 7 (human)
Definition A growth factor receptor-bound protein 7 that is encoded in the genome of human.
Short Label hGRB7
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14451 (GRB7) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T23 Phosphorylation PhosphoSitePlus
T27 Phosphorylation PhosphoSitePlus
T33 Phosphorylation PhosphoSitePlus
S42 Phosphorylation PhosphoSitePlus
T49 Phosphorylation PhosphoSitePlus
T50 Phosphorylation PhosphoSitePlus
T62 Phosphorylation PhosphoSitePlus
S66 Phosphorylation PhosphoSitePlus
S76 Phosphorylation PhosphoSitePlus
S79 Phosphorylation PhosphoSitePlus
S81 Phosphorylation PhosphoSitePlus
Y107 Phosphorylation PhosphoSitePlus
S108 Phosphorylation PhosphoSitePlus
Y188 Phosphorylation Q05397 (PTK2) PhosphoSitePlus   UniProt 20622016, 19473962
S193 Phosphorylation PhosphoSitePlus
S194 Phosphorylation PhosphoSitePlus   RLIMS-P 27658202
Y259 Phosphorylation PhosphoSitePlus
Y284 Phosphorylation PhosphoSitePlus
K291 Acetylation PhosphoSitePlus
K307 Acetylation PhosphoSitePlus
Y338 Phosphorylation Q05397 (PTK2) PhosphoSitePlus   UniProt 20622016, 19473962
Y343 Phosphorylation PhosphoSitePlus
S361 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S366 Phosphorylation PhosphoSitePlus
S368 Phosphorylation PhosphoSitePlus
S378 Phosphorylation PhosphoSitePlus
S393 Phosphorylation PhosphoSitePlus
S411 Phosphorylation PhosphoSitePlus
S417 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S361 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T27 I27 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T50 I50 Biomuta DOID:4159 / skin cancer [ cosmic ]
T62 I62 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S66 F66 Biomuta DOID:4159 / skin cancer [ cosmic ]
S76 R76 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
S76 C76 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y259 C259 Biomuta DOID:1324 / lung cancer [ cosmic ]
K307 N307 Biomuta DOID:3571 / liver cancer [ cosmic ]
S361 C361 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S361 F361 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]