Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14449 / GRB14_HUMAN
Protein Name Growth factor receptor-bound protein 14
Gene Name Name: GRB14
Organism Homo sapiens (Human)

PRO ID PR:Q14449
DAG View
PRO Name growth factor receptor-bound protein 14 (human)
Definition A growth factor receptor-bound protein 14 that is encoded in the genome of human.
Short Label hGRB14
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14449 (GRB14) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T2 Acetylation UniProt 19413330
Y113 Phosphorylation PhosphoSitePlus
Y347 Phosphorylation RLIMS-P 21791607
S358 Phosphorylation PhosphoSitePlus
S362 Phosphorylation PhosphoSitePlus
S366 Phosphorylation PhosphoSitePlus   RLIMS-P 24535599
S370 Phosphorylation PhosphoSitePlus
S372 Phosphorylation PhosphoSitePlus
S375 Phosphorylation PhosphoSitePlus
S419 Phosphorylation PhosphoSitePlus
T421 Phosphorylation PhosphoSitePlus
S423 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S370 Phosphorylation HPRD 20166139
S372 Phosphorylation HPRD 20166139


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q14449 (GRB14) Y347 P18031 (PTPN1) unknown eFIP 21791607


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S372 P372 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
S375 F375 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S419 I419 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
T421 P421 Biomuta DOID:1612 / breast cancer [ icgc ]