iPTMnet Report for Q14432 (PDE3A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14432 / PDE3A_HUMAN
Protein Name cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
Gene Name Name: PDE3A
Organism Homo sapiens (Human)

PRO ID PR:Q14432
DAG View
PRO Name cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (human)
Definition A cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A that is encoded in the genome of human.
Short Label hPDE3A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14432 (PDE3A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K287 Ubiquitination PhosphoSitePlus
S292 Phosphorylation PhosphoSitePlus 25593322
S292 Phosphorylation P17252 (PRKCA) PhosphoSitePlus 25593322
S293 Phosphorylation PhosphoSitePlus 25593322
S293 Phosphorylation P17252 (PRKCA) PhosphoSitePlus 25593322
S294 Phosphorylation PhosphoSitePlus
S297 Phosphorylation PhosphoSitePlus
S301 Phosphorylation PhosphoSitePlus
S312 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 31289200, 18088087, 18212344, ...19261611, 24248367, 17322306, 16153182, 18669648, 20166139, 23186163, 20068231
S312 Phosphorylation P17252 (PRKCA) PhosphoSitePlus   Signor 19261611, 16153182
S312 Phosphorylation P17612 (PRKACA) PhosphoSitePlus   Signor 16153182, 24248367
T399 O-Glycosylation GlyGen 31373491
T399 Phosphorylation PhosphoSitePlus
S400 Phosphorylation PhosphoSitePlus
S402 Phosphorylation PhosphoSitePlus
T406 O-Glycosylation GlyGen 31373491
S408 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S410 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S413 Phosphorylation PhosphoSitePlus
K418 Ubiquitination PhosphoSitePlus
S428 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 31289200, 18212344, 19261611, ...24248367, 16153182, 18669648, 25961942, 20068231, 16964243
S428 Phosphorylation P17252 (PRKCA) PhosphoSitePlus   Signor 19261611, 16153182
S428 Phosphorylation P17612 (PRKACA) PhosphoSitePlus 24248367
S438 Phosphorylation PhosphoSitePlus   RLIMS-P   Signor   UniProt 19261611, 25961942
S438 Phosphorylation P17252 (PRKCA) PhosphoSitePlus   Signor 19261611
S439 Phosphorylation PhosphoSitePlus
T440 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
T442 Phosphorylation PhosphoSitePlus
T443 Phosphorylation PhosphoSitePlus
T444 Phosphorylation PhosphoSitePlus
T445 Phosphorylation PhosphoSitePlus
S463 Phosphorylation PhosphoSitePlus
S465 Phosphorylation PhosphoSitePlus   RLIMS-P   Signor 19261611
S465 Phosphorylation P17252 (PRKCA) PhosphoSitePlus   Signor 19261611
K467 Ubiquitination PhosphoSitePlus
S474 O-Glycosylation GlyGen 31373491
S475 Phosphorylation HPRD   PhosphoSitePlus 20068231
S478 O-Glycosylation GlyGen 31373491
S478 Phosphorylation PhosphoSitePlus
K489 Ubiquitination PhosphoSitePlus
S492 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19261611, 23186163, 18767875
S492 Phosphorylation P17252 (PRKCA) PhosphoSitePlus   Signor 19261611
T494 Phosphorylation PhosphoSitePlus
Y497 Phosphorylation PhosphoSitePlus
K506 Ubiquitination PhosphoSitePlus
K518 Ubiquitination PhosphoSitePlus
S520 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 16964243
S523 Phosphorylation PhosphoSitePlus
S524 Phosphorylation PhosphoSitePlus
S527 Phosphorylation PhosphoSitePlus
S528 Phosphorylation PhosphoSitePlus
T533 O-Glycosylation GlyGen 31373491
T533 Phosphorylation PhosphoSitePlus
K541 Ubiquitination PhosphoSitePlus
S543 O-Glycosylation GlyGen 31373491
S550 Phosphorylation PhosphoSitePlus
T553 Phosphorylation PhosphoSitePlus
T554 O-Glycosylation GlyGen 28510447, 31373491
T554 Phosphorylation PhosphoSitePlus
K556 Ubiquitination PhosphoSitePlus
S558 Phosphorylation PhosphoSitePlus
S561 Phosphorylation PhosphoSitePlus
T568 Phosphorylation PhosphoSitePlus
S570 Phosphorylation PhosphoSitePlus
S575 Phosphorylation PhosphoSitePlus
T580 Phosphorylation PhosphoSitePlus
S593 Phosphorylation PhosphoSitePlus
S613 Phosphorylation PhosphoSitePlus
T615 Phosphorylation HPRD 17081983
T618 Phosphorylation HPRD 17081983
T643 Phosphorylation PhosphoSitePlus
S654 Phosphorylation PhosphoSitePlus   RLIMS-P 34252457
K729 Ubiquitination PhosphoSitePlus
K912 Ubiquitination PhosphoSitePlus
K919 Ubiquitination PhosphoSitePlus
K923 Ubiquitination PhosphoSitePlus
K947 Ubiquitination PhosphoSitePlus
K956 Ubiquitination PhosphoSitePlus
K1088 Ubiquitination PhosphoSitePlus
S1103 Phosphorylation PhosphoSitePlus
T1107 Phosphorylation PhosphoSitePlus
K1120 Ubiquitination PhosphoSitePlus
T1136 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S293 G293 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S301 F301 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S312 P312 Biomuta DOID:1612 / breast cancer [ icgc ]
S400 L400 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T406 A406 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S413 I413 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T440 S440 Biomuta DOID:1324 / lung cancer [ cosmic ]
S463 N463 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S465 G465 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S475 C475 Biomuta DOID:1324 / lung cancer [ cosmic ]
K489 Q489 Biomuta DOID:4159 / skin cancer [ cosmic ]
K506 N506 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ] DOID:263 / kidney cancer [ cosmic, icgc ]
S523 * Biomuta DOID:4362 / cervical cancer [ cosmic ]
S523 L523 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S524 L524 Biomuta DOID:4159 / skin cancer [ cosmic ]
S527 F527 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K541 T541 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T553 A553 Biomuta [ cosmic ]
K556 R556 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
T568 S568 Biomuta DOID:1324 / lung cancer [ cosmic ]
S575 F575 Biomuta DOID:4159 / skin cancer [ cosmic ]
T580 I580 Biomuta DOID:4159 / skin cancer [ cosmic ]
S613 C613 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
T615 A615 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S654 L654 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ]
K947 Q947 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K956 E956 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]