iPTMnet Report for Q14315 (FLNC)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14315 / FLNC_HUMAN
Protein Name Filamin-C
Gene Name Name: FLNC
Synonyms:ABPL,FLN2;
Organism Homo sapiens (Human)

PRO ID PR:Q14315
DAG View
PRO Name filamin-C (human)
Definition A filamin-C that is encoded in the genome of human.
Short Label hFLNC
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14315 (FLNC) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S5 Phosphorylation PhosphoSitePlus   UniProt 23186163
K35 Acetylation PhosphoSitePlus
K35 Methylation PhosphoSitePlus
K35 Ubiquitination PhosphoSitePlus
K36 Ubiquitination PhosphoSitePlus
T41 Phosphorylation PhosphoSitePlus
T43 Phosphorylation PhosphoSitePlus
S78 Phosphorylation PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
S116 Phosphorylation PhosphoSitePlus
K162 Acetylation PhosphoSitePlus
K189 Ubiquitination PhosphoSitePlus
S379 Phosphorylation PhosphoSitePlus
Y397 Phosphorylation PhosphoSitePlus
Y401 Phosphorylation PhosphoSitePlus
T423 Phosphorylation PhosphoSitePlus
K498 Ubiquitination PhosphoSitePlus
T501 Phosphorylation PhosphoSitePlus
K502 Ubiquitination PhosphoSitePlus
T512 Phosphorylation PhosphoSitePlus
Y545 Phosphorylation PhosphoSitePlus
S559 Phosphorylation PhosphoSitePlus
S566 Phosphorylation PhosphoSitePlus
K621 Acetylation PhosphoSitePlus
S625 Phosphorylation PhosphoSitePlus
C728 S-Nitrosylation dbSNO 26338901
K734 Acetylation PhosphoSitePlus
Y770 Phosphorylation PhosphoSitePlus
K776 Acetylation PhosphoSitePlus
K776 Ubiquitination PhosphoSitePlus
Y833 Phosphorylation PhosphoSitePlus
T834 Phosphorylation PhosphoSitePlus
K886 Methylation PhosphoSitePlus
K895 Ubiquitination PhosphoSitePlus
S927 Phosphorylation PhosphoSitePlus
S954 Phosphorylation PhosphoSitePlus
K968 Acetylation PhosphoSitePlus
R1002 Methylation PhosphoSitePlus
S1005 Phosphorylation PhosphoSitePlus
K1014 Acetylation PhosphoSitePlus
K1014 Ubiquitination PhosphoSitePlus
Y1068 Phosphorylation PhosphoSitePlus
K1073 Ubiquitination PhosphoSitePlus
T1079 Phosphorylation PhosphoSitePlus
C1103 S-Nitrosylation dbSNO 20140087
S1156 Phosphorylation PhosphoSitePlus
S1161 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18088087
T1240 Phosphorylation PhosphoSitePlus
K1299 Ubiquitination PhosphoSitePlus
T1300 Phosphorylation PhosphoSitePlus
T1302 Phosphorylation PhosphoSitePlus
Y1303 Phosphorylation PhosphoSitePlus
T1305 Phosphorylation PhosphoSitePlus
Y1312 Phosphorylation PhosphoSitePlus
K1337 Acetylation PhosphoSitePlus
S1338 Phosphorylation PhosphoSitePlus   UniProt 24275569
C1348 S-Nitrosylation dbSNO 2212679, 22126794
K1367 Acetylation PhosphoSitePlus
K1367 Ubiquitination PhosphoSitePlus
S1527 Phosphorylation PhosphoSitePlus
K1532 Ubiquitination PhosphoSitePlus
Y1602 Phosphorylation PhosphoSitePlus
S1624 Phosphorylation PhosphoSitePlus
S1728 Phosphorylation PhosphoSitePlus
T1799 Phosphorylation PhosphoSitePlus
T1809 Phosphorylation PhosphoSitePlus
T1821 Phosphorylation PhosphoSitePlus
T1823 Phosphorylation PhosphoSitePlus
K1831 Acetylation PhosphoSitePlus
S1848 Phosphorylation PhosphoSitePlus
S1893 Phosphorylation PhosphoSitePlus
S1900 Phosphorylation PhosphoSitePlus
S1940 Phosphorylation PhosphoSitePlus
T1943 Phosphorylation PhosphoSitePlus
S1972 Phosphorylation PhosphoSitePlus
S1975 Phosphorylation PhosphoSitePlus
T1978 Phosphorylation PhosphoSitePlus
S1980 Phosphorylation PhosphoSitePlus
K1994 Acetylation PhosphoSitePlus
K1994 Ubiquitination PhosphoSitePlus
T2006 Phosphorylation PhosphoSitePlus
S2016 Phosphorylation PhosphoSitePlus
T2025 Phosphorylation PhosphoSitePlus
S2027 Phosphorylation PhosphoSitePlus
K2030 Acetylation PhosphoSitePlus
K2030 Ubiquitination PhosphoSitePlus
S2042 Phosphorylation PhosphoSitePlus   UniProt 23186163
S2122 Phosphorylation PhosphoSitePlus
T2125 Phosphorylation PhosphoSitePlus
K2127 Ubiquitination PhosphoSitePlus
S2137 Phosphorylation PhosphoSitePlus
S2146 Phosphorylation PhosphoSitePlus
S2152 Phosphorylation RLIMS-P 25666618, 22194892
T2179 Phosphorylation PhosphoSitePlus
S2233 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 19369195, 21406692, 23186163, ...15461588, 32444788, 24275569
S2233 Phosphorylation P31749 (AKT1) neXtProt   PhosphoSitePlus 15461588
S2233 Phosphorylation P31751 (AKT2) neXtProt   PhosphoSitePlus 15461588
S2236 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 32444788, 23186163
T2238 Phosphorylation PhosphoSitePlus   UniProt 23186163
S2256 Phosphorylation PhosphoSitePlus
Y2274 Phosphorylation PhosphoSitePlus
K2291 Ubiquitination PhosphoSitePlus
R2293 Methylation PhosphoSitePlus
S2300 Phosphorylation PhosphoSitePlus
K2316 Methylation PhosphoSitePlus
K2316 Ubiquitination PhosphoSitePlus
S2348 Phosphorylation PhosphoSitePlus
S2395 Phosphorylation PhosphoSitePlus
T2412 Phosphorylation PhosphoSitePlus
T2414 Phosphorylation PhosphoSitePlus
S2415 Phosphorylation PhosphoSitePlus
T2446 Phosphorylation PhosphoSitePlus
Y2455 Phosphorylation PhosphoSitePlus
S2457 Phosphorylation PhosphoSitePlus
S2490 O-Glycosylation GlyGen 23301498, 16408927, 33214551, ...30379171, 34725712, 29351928, 34019948, 34229054
S2490 Phosphorylation PhosphoSitePlus
K2493 Acetylation PhosphoSitePlus
Y2577 Phosphorylation PhosphoSitePlus
S2586 Phosphorylation PhosphoSitePlus   UniProt 23186163
S2598 Phosphorylation PhosphoSitePlus
S2602 Phosphorylation PhosphoSitePlus
T2613 Phosphorylation PhosphoSitePlus
T2615 Phosphorylation PhosphoSitePlus
S2617 Phosphorylation PhosphoSitePlus   UniProt 23186163
S2619 Phosphorylation PhosphoSitePlus
S2620 Phosphorylation PhosphoSitePlus   UniProt 23186163
S2623 Phosphorylation PhosphoSitePlus   UniProt 23186163
S2624 Phosphorylation PhosphoSitePlus
Y2625 Phosphorylation PhosphoSitePlus
S2626 Phosphorylation PhosphoSitePlus
S2627 Phosphorylation PhosphoSitePlus
K2630 Ubiquitination PhosphoSitePlus
S2632 Phosphorylation PhosphoSitePlus   UniProt 23186163
S2646 Phosphorylation PhosphoSitePlus
K2653 Ubiquitination PhosphoSitePlus
S2655 Phosphorylation PhosphoSitePlus
T2677 Phosphorylation PhosphoSitePlus
C2679 S-Nitrosylation dbSNO 26338901, 22126794
Y2683 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
K2685 Acetylation PhosphoSitePlus
K2699 Acetylation PhosphoSitePlus
Y2704 Phosphorylation PhosphoSitePlus
S2714 Phosphorylation PhosphoSitePlus   UniProt 23186163
S2718 Phosphorylation PhosphoSitePlus   UniProt 23186163
Site PTM Type PTM Enzyme Score Source PMID
Y770 Phosphorylation HPRD 18691976
S1161 Phosphorylation HPRD 18088087
S1972 Phosphorylation HPRD 20058876
S2233 Phosphorylation HPRD 18578522, 18212344, 20058876, ...19664994, 19664995, 19651622, 18707149, 20068231
S2236 Phosphorylation HPRD 19664994
Y2683 Phosphorylation HPRD 18083107


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T43 M43 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K189 R189 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y397 S397 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y545 H545 Biomuta DOID:1324 / lung cancer [ cosmic ]
K886 N886 Biomuta DOID:263 / kidney cancer [ cosmic ]
S927 F927 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S954 N954 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
R1002 W1002 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
R1002 Q1002 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ]
S1005 L1005 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:5041 / esophageal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K1073 N1073 Biomuta DOID:4159 / skin cancer [ cosmic ]
T1079 P1079 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
C1103 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S1156 N1156 Biomuta DOID:4159 / skin cancer [ cosmic ]
K1299 N1299 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K1337 N1337 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
C1348 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
C1348 Y1348 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
C1348 W1348 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1532 R1532 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S1624 L1624 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T1823 M1823 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S1900 F1900 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S1975 N1975 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S2152 R2152 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R2293 C2293 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
R2293 H2293 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R2293 S2293 Biomuta DOID:1324 / lung cancer [ cosmic ]
S2348 F2348 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y2455 C2455 Biomuta DOID:1324 / lung cancer [ cosmic ]
S2490 N2490 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S2619 T2619 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y2625 F2625 Biomuta DOID:1324 / lung cancer [ cosmic ]
S2626 N2626 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]