iPTMnet Report for Q14258 (TRIM25)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14258 / TRI25_HUMAN
Protein Name E3 ubiquitin/ISG15 ligase TRIM25
Gene Name Name: TRIM25
Synonyms:EFP;
Organism Homo sapiens (Human)

PRO ID PR:Q14258
DAG View
PRO Name E3 ubiquitin/ISG15 ligase TRIM25 (human)
Definition An E3 ubiquitin/ISG15 ligase TRIM25 that is encoded in the genome of human.
Short Label hTRIM25
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14258 (TRIM25) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S12 Phosphorylation PhosphoSitePlus   RLIMS-P 32576271
S46 Phosphorylation PhosphoSitePlus
Y48 Phosphorylation PhosphoSitePlus
Y57 Phosphorylation PhosphoSitePlus
T67 Phosphorylation PhosphoSitePlus
T91 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S97 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S100 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18767875, 18669648, 23186163, ...20068231
K112 Ubiquitination PhosphoSitePlus
K117 Ubiquitination PhosphoSitePlus
C119 Methylation IEDB 31844290
S158 Phosphorylation PhosphoSitePlus
S187 Phosphorylation PhosphoSitePlus
S190 Phosphorylation PhosphoSitePlus
S192 Phosphorylation PhosphoSitePlus
K205 Ubiquitination PhosphoSitePlus
K237 Ubiquitination PhosphoSitePlus
Y245 Phosphorylation PhosphoSitePlus
T246 Phosphorylation PhosphoSitePlus
K249 Ubiquitination PhosphoSitePlus
T258 Phosphorylation PhosphoSitePlus
K268 Ubiquitination PhosphoSitePlus
K273 Acetylation PhosphoSitePlus   UniProt 19608861
K273 Ubiquitination PhosphoSitePlus
T276 Phosphorylation PhosphoSitePlus
Y278 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 15592455, 30100205, 24275569
K283 Methylation PhosphoSitePlus
K283 Ubiquitination PhosphoSitePlus
K284 Methylation PhosphoSitePlus
K284 Ubiquitination PhosphoSitePlus
K285 Ubiquitination PhosphoSitePlus
T290 Phosphorylation PhosphoSitePlus
K292 Ubiquitination PhosphoSitePlus
K301 Ubiquitination PhosphoSitePlus
K310 Ubiquitination PhosphoSitePlus
S312 Phosphorylation PhosphoSitePlus
T319 Phosphorylation PhosphoSitePlus
K320 Acetylation PhosphoSitePlus
K320 Ubiquitination PhosphoSitePlus
Y323 Phosphorylation PhosphoSitePlus
K332 Ubiquitination PhosphoSitePlus
K335 Ubiquitination PhosphoSitePlus
S340 Phosphorylation PhosphoSitePlus
K345 Ubiquitination PhosphoSitePlus
K349 Ubiquitination PhosphoSitePlus
R378 Methylation PhosphoSitePlus
K392 Ubiquitination PhosphoSitePlus
K402 Acetylation PhosphoSitePlus
K402 Ubiquitination PhosphoSitePlus
T405 Phosphorylation PhosphoSitePlus
K416 Methylation PhosphoSitePlus
K416 Ubiquitination PhosphoSitePlus
K425 Methylation PhosphoSitePlus
K425 Ubiquitination PhosphoSitePlus
T427 Phosphorylation HPRD 20068231
S429 Phosphorylation IEDB   PhosphoSitePlus 32387766
S433 Phosphorylation PhosphoSitePlus
T434 Phosphorylation PhosphoSitePlus
S435 Phosphorylation PhosphoSitePlus
K437 Methylation PhosphoSitePlus
K437 Ubiquitination PhosphoSitePlus
K439 Ubiquitination PhosphoSitePlus
K447 Ubiquitination PhosphoSitePlus
Y455 Phosphorylation PhosphoSitePlus
C506 Methylation IEDB 31844290
K508 Ubiquitination PhosphoSitePlus
K509 Ubiquitination PhosphoSitePlus
K567 Acetylation PhosphoSitePlus   UniProt 19608861
K567 Ubiquitination PhosphoSitePlus
K573 Ubiquitination PhosphoSitePlus
C627 Methylation IEDB 31844290


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O95786 (RIGI) S8 Q14258 (TRIM25) decreased_association eFIP 20406818