iPTMnet Report for Q14254 (FLOT2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14254 / FLOT2_HUMAN
Protein Name Flotillin-2
Gene Name Name: FLOT2
Synonyms:ESA1,M17S1;
Organism Homo sapiens (Human)

PRO ID PR:Q14254
DAG View
PRO Name flotillin-2 (human)
Definition A flotillin-2 that is encoded in the genome of human.
Short Label hFLOT2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14254 (FLOT2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
G2 Myristoylation UniProt 25255805
K81 Ubiquitination PhosphoSitePlus
K100 Ubiquitination PhosphoSitePlus
Y124 Phosphorylation PhosphoSitePlus
R127 Methylation PhosphoSitePlus
K160 Ubiquitination PhosphoSitePlus
Y163 Phosphorylation P06241 (FYN) PhosphoSitePlus 19258392
S166 Phosphorylation PhosphoSitePlus
K169 Ubiquitination PhosphoSitePlus
T172 Phosphorylation PhosphoSitePlus
C197 Methylation IEDB 31844290
S227 Phosphorylation PhosphoSitePlus
Y241 Phosphorylation HPRD   PhosphoSitePlus 19901323, 17389395
T285 Phosphorylation IEDB   PhosphoSitePlus 35494241
K305 Ubiquitination PhosphoSitePlus
K307 Ubiquitination PhosphoSitePlus
K335 Ubiquitination PhosphoSitePlus
K344 Ubiquitination PhosphoSitePlus
Y348 Phosphorylation PhosphoSitePlus
K350 Ubiquitination PhosphoSitePlus
Y351 Phosphorylation PhosphoSitePlus
K370 Ubiquitination PhosphoSitePlus
K377 Ubiquitination PhosphoSitePlus
S385 Phosphorylation PhosphoSitePlus
S389 Phosphorylation PhosphoSitePlus
K390 Ubiquitination PhosphoSitePlus
T392 Phosphorylation PhosphoSitePlus
S405 Phosphorylation PhosphoSitePlus   UniProt 24275569
K421 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K100 Q100 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R127 Q127 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S166 F166 Biomuta DOID:4159 / skin cancer [ cosmic ]
K169 T169 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
Y241 C241 Biomuta DOID:3571 / liver cancer [ cosmic ]
K335 E335 Biomuta DOID:1612 / breast cancer [ cosmic ]