iPTMnet Report for Q14249 (ENDOG)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14249 / NUCG_HUMAN
Protein Name Endonuclease G, mitochondrial precursor
Gene Name Name: ENDOG
Organism Homo sapiens (Human)

PRO ID PR:Q14249
DAG View
PRO Name endonuclease G, mitochondrial (human)
Definition An endonuclease G, mitochondrial that is encoded in the genome of human.
Short Label hENDOG
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14249 (ENDOG) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T9 Phosphorylation PhosphoSitePlus
S12 Phosphorylation PhosphoSitePlus
K66 Ubiquitination PhosphoSitePlus
K76 Ubiquitination PhosphoSitePlus
T128 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 33473107
K153 Ubiquitination PhosphoSitePlus
K181 Ubiquitination PhosphoSitePlus
K210 Ubiquitination PhosphoSitePlus
K214 Ubiquitination PhosphoSitePlus
K220 Ubiquitination PhosphoSitePlus
S288 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 33473107
K290 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S12 L12 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
K66 N66 Biomuta [ cosmic ]
K76 R76 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K76 M76 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T128 I128 Biomuta DOID:3571 / liver cancer [ cosmic ]