Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14247 / SRC8_HUMAN
Protein Name Src substrate cortactin
Gene Name Name: CTTN
Synonyms:EMS1;
Organism Homo sapiens (Human)

PRO ID PR:Q14247
DAG View
PRO Name Src substrate cortactin (human)
Definition A Src substrate cortactin that is encoded in the genome of human.
Short Label hCTTN
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14247 (CTTN) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K3 Methylation PhosphoSitePlus
S11 Phosphorylation PhosphoSitePlus
T24 Phosphorylation PhosphoSitePlus   RLIMS-P 30610108
S33 Phosphorylation PhosphoSitePlus
K35 Ubiquitination PhosphoSitePlus
K42 Ubiquitination PhosphoSitePlus
T43 Phosphorylation PhosphoSitePlus
S47 Phosphorylation PhosphoSitePlus   RLIMS-P 32369440
K57 Ubiquitination PhosphoSitePlus
T68 Phosphorylation PhosphoSitePlus
K70 Methylation PhosphoSitePlus
K72 Methylation PhosphoSitePlus
K79 Methylation PhosphoSitePlus
K79 Ubiquitination PhosphoSitePlus
S81 Phosphorylation PhosphoSitePlus
Y84 Phosphorylation PhosphoSitePlus
K87 Acetylation PhosphoSitePlus   UniProt 19608861
K87 Methylation PhosphoSitePlus
K87 Ubiquitination PhosphoSitePlus
S98 Phosphorylation PhosphoSitePlus
Y104 Phosphorylation PhosphoSitePlus
S106 Phosphorylation PhosphoSitePlus
K107 Acetylation PhosphoSitePlus
K107 Methylation PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
S109 Phosphorylation PhosphoSitePlus
K110 Acetylation PhosphoSitePlus
K110 Ubiquitination PhosphoSitePlus
C112 S-Nitrosylation dbSNO 2212679, 22126794
S113 Phosphorylation phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P 26490115, 17287340, 24859002, ...30562756, 28287395
S117 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
R119 Methylation PhosphoSitePlus
K124 Acetylation PhosphoSitePlus
K124 Methylation PhosphoSitePlus
K124 Ubiquitination PhosphoSitePlus
R131 Methylation PhosphoSitePlus
S135 Phosphorylation PhosphoSitePlus
Y141 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
K144 Acetylation PhosphoSitePlus
K144 Sumoylation PhosphoSitePlus
K144 Ubiquitination PhosphoSitePlus
K147 Acetylation PhosphoSitePlus
S150 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 28287395, 24275569
K152 Ubiquitination PhosphoSitePlus
Y154 Phosphorylation PhosphoSitePlus
S155 Phosphorylation PhosphoSitePlus
S156 Phosphorylation PhosphoSitePlus
K161 Acetylation PhosphoSitePlus
K161 Methylation PhosphoSitePlus
K161 Ubiquitination PhosphoSitePlus
Y162 Phosphorylation PhosphoSitePlus
R168 Methylation PhosphoSitePlus
K171 Acetylation PhosphoSitePlus
K171 Ubiquitination PhosphoSitePlus
S172 Phosphorylation PhosphoSitePlus
Y178 Phosphorylation PhosphoSitePlus
K181 Acetylation PhosphoSitePlus
K181 Sumoylation PhosphoSitePlus
T182 Phosphorylation PhosphoSitePlus
S187 Phosphorylation PhosphoSitePlus
Y191 Phosphorylation PhosphoSitePlus
S192 Phosphorylation PhosphoSitePlus
K193 Ubiquitination PhosphoSitePlus
K198 Acetylation PhosphoSitePlus   UniProt 19608861
K198 Ubiquitination PhosphoSitePlus
Y199 Phosphorylation PhosphoSitePlus
K203 Acetylation PhosphoSitePlus
K208 Ubiquitination PhosphoSitePlus
S209 Phosphorylation PhosphoSitePlus
Y215 Phosphorylation PhosphoSitePlus
K218 Acetylation PhosphoSitePlus
K218 Sumoylation PhosphoSitePlus
T219 Phosphorylation PhosphoSitePlus
S224 Phosphorylation PhosphoSitePlus
K226 Ubiquitination PhosphoSitePlus
Y228 Phosphorylation PhosphoSitePlus
K230 Ubiquitination PhosphoSitePlus
K235 Acetylation PhosphoSitePlus   UniProt 19608861
K235 Methylation PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
R242 Methylation PhosphoSitePlus
K245 Ubiquitination PhosphoSitePlus
S261 Phosphorylation P41743 (PRKCI) PhosphoSitePlus   UniProt 24753582, 23186163, 24275569
K263 Acetylation PhosphoSitePlus
K263 Ubiquitination PhosphoSitePlus
Y265 Phosphorylation PhosphoSitePlus
K266 Ubiquitination PhosphoSitePlus
T267 Phosphorylation PhosphoSitePlus
K272 Acetylation PhosphoSitePlus   UniProt 19608861
K272 Methylation PhosphoSitePlus
K272 Ubiquitination PhosphoSitePlus
S277 Phosphorylation PhosphoSitePlus
S282 Phosphorylation PhosphoSitePlus   RLIMS-P 28287395
Y289 Phosphorylation PhosphoSitePlus
K290 Acetylation PhosphoSitePlus
K290 Ubiquitination PhosphoSitePlus
K295 Acetylation PhosphoSitePlus
K295 Sumoylation PhosphoSitePlus
S298 Phosphorylation Q15139 (PRKD1) , O14757 (CHEK1) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 26490115, 31727638, 21851590, ...20363754, 19038333
Y302 Phosphorylation PhosphoSitePlus
S303 Phosphorylation PhosphoSitePlus
K304 Acetylation PhosphoSitePlus   UniProt 19608861
K304 Ubiquitination PhosphoSitePlus
K309 Acetylation PhosphoSitePlus   UniProt 19608861
K309 Methylation PhosphoSitePlus
Y310 Phosphorylation PhosphoSitePlus
K319 Acetylation PhosphoSitePlus
S322 Phosphorylation PhosphoSitePlus
T323 Phosphorylation PhosphoSitePlus
S331 O-Glycosylation GlyGen 23301498, 30397120, 30059200, ...32119511, 28657654, 29237092
S331 Phosphorylation PhosphoSitePlus
S332 Phosphorylation PhosphoSitePlus
Y334 Phosphorylation P12931 (SRC) phospho.ELM   PhosphoSitePlus 18698806, 16212419
K336 Ubiquitination PhosphoSitePlus
T337 Phosphorylation PhosphoSitePlus
S345 O-Glycosylation GlyGen 23301498, 30397120, 30059200, ...32119511, 28657654, 29237092
S345 Phosphorylation PhosphoSitePlus
K346 Ubiquitination PhosphoSitePlus
S348 Phosphorylation Q15139 (PRKD1) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 26490115, 19038333
K390 Acetylation PhosphoSitePlus
T399 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18088087, 18669648, 24275569, ...23186163, 17287340, 20068231
T401 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18088087, 17081983, 18220336, ...15302935, 15144186, 18669648, 24275569, 23186163, 17287340, 25247763, 20068231
S405 Phosphorylation Q05655 (PRKCD) , P06493 (CDK1) , P28482 (MAPK1) , Q13153 (PAK1) , P24941 (CDK2) , P27361 (MAPK3) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 26490115, 16964243, 20444238, ...21079800, 23186163, 27363897, 23519612, 18234856, 24275569, 10537323, 22952966, 18088087, 18220336, 18847512, 15144186, 25247763, 17287340, 17081983, 19690332, 18669648, 20068231
T411 Phosphorylation PhosphoSitePlus   UniProt 18669648
R414 Methylation PhosphoSitePlus
S417 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18669648, 17287340, 25247763
S418 Phosphorylation P28482 (MAPK1) , Q13153 (PAK1) , P27361 (MAPK3) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 26490115, 18088087, 16964243, ...27363897, 23519612, 20444238, 21655441, 21079800, 21406692, 19690332, 18669648, 23186163, 25247763, 10537323, 22952966, 20068231, 17081983
Y421 Phosphorylation P00519 (ABL1) , P42684 (ABL2) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 29133485, 32363035, 21079800, ...30976201, 30285892, 26103422, 25682866, 28983097, 22078467, 12522270, 29643476, 24465712, 20041195, 23423155, 23038781, 27339664, 27705916, 23552693, 22952966, 32844749, 12925758, 18088087, 30098172, 27363897, 27824079, 15169891, 17287340, 24477238, 25772245, 22761768, 17306540, 19690332, 32035133, 9748248, 18669648, 16905744, 26447611
S426 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S432 Phosphorylation PhosphoSitePlus
Y433 Phosphorylation PhosphoSitePlus
S438 Phosphorylation PhosphoSitePlus   UniProt 23186163
T440 Phosphorylation PhosphoSitePlus
Y446 Phosphorylation P12931 (SRC) , P11362 (FGFR1) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18387954, 12601080, 27363897, ...24465712, 16212419, 27824079, 15592455, 19690332
S447 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
Y453 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15592455, 16212419
Y464 Phosphorylation PhosphoSitePlus
Y470 Phosphorylation P42684 (ABL2) , P12931 (SRC) , P00519 (ABL1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 24465712, 12601080, 17306540, ...27339664, 9748248, 20708589, 7519605
Y479 Phosphorylation PhosphoSitePlus
T485 Phosphorylation PhosphoSitePlus
Y486 Phosphorylation P12931 (SRC) , P42684 (ABL2) , P00519 (ABL1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 24465712, 12601080, 20861316, ...17306540, 15561106, 17959782, 9748248
Y538 Phosphorylation PhosphoSitePlus
Y545 Phosphorylation PhosphoSitePlus
R549 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S11 Phosphorylation HPRD 16825425
T24 Phosphorylation HPRD 16825425
S113 Phosphorylation HPRD 17287340, 18212344
S117 Phosphorylation HPRD 17287340, 18212344
S135 Phosphorylation HPRD 16825425
Y141 Phosphorylation HPRD 18083107
S150 Phosphorylation HPRD 16825425
S172 Phosphorylation HPRD 16825425
T182 Phosphorylation HPRD 16825425
S209 Phosphorylation HPRD 16825425
S261 Phosphorylation HPRD 20068231
S282 Phosphorylation HPRD 20068231, 16825425
Y289 Phosphorylation HPRD 20068231
Y334 Phosphorylation HPRD 16212419
S345 Phosphorylation HPRD 20068231, 16825425
S348 Phosphorylation HPRD 16825425
T399 Phosphorylation HPRD 19413330, 18691976, 18491316, ...18088087, 18212344, 19562805, 18767875, 18077418, 20058876, 19664995, 19651622, 17322306, 18669648, 20166139, 17287340, 19415658, 20068231
T401 Phosphorylation HPRD 19413330, 18691976, 18491316, ...17287340, 18767875, 18077418, 15302935, 19664995, 15144186, 18452278, 19651622, 19664994, 18669648, 20058876, 18707149, 20166139, 18088087, 19415658, 20068231
S405 Phosphorylation HPRD 19413330, 18691976, 18088087, ...16964243, 18767875, 18077418, 15302935, 19664995, 18452278, 19651622, 19664994, 18669648, 18707149, 20166139, 17287340, 19415658, 20068231, 18212344
T411 Phosphorylation HPRD 18691976, 18669648, 17081983
S417 Phosphorylation HPRD 19413330, 18691976, 18491316, ...17287340, 17081983, 19664995, 18452278, 19651622, 18669648, 20166139, 20068231
S418 Phosphorylation HPRD 19413330, 18491316, 18088087, ...16964243, 20230923, 18767875, 15302935, 19691289, 19664995, 19651622, 19664994, 18669648, 20058876, 18707149, 20166139, 18452278, 19415658, 20068231, 18212344
Y421 Phosphorylation P16591 (FER) , P12931 (SRC) HPRD 17016520, 19413330, 17389395, ...17287340, 10921917, 9748248, 18669648, 18491316, 18707149, 18088087, 20068231, 16497976
S426 Phosphorylation HPRD 18669648, 17081983, 20068231
Y433 Phosphorylation HPRD 17016520
Y446 Phosphorylation HPRD 15951569, 17389395, 20068231, ...18707149
Y453 Phosphorylation HPRD 16212419, 18707149
Y470 Phosphorylation P12931 (SRC) HPRD 9748248
Y486 Phosphorylation P12931 (SRC) HPRD 9748248
Site PTM Type PTM Enzyme Score Source PMID
S261 Phosphorylation PhosphoSitePlus
Y466 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S11 Phosphorylation HPRD 16825425
T24 Phosphorylation HPRD   PhosphoSitePlus 16825425
Y104 Phosphorylation PhosphoSitePlus
S113 Phosphorylation HPRD 17287340, 18212344
S117 Phosphorylation HPRD 17287340, 18212344
S135 Phosphorylation HPRD 16825425
Y141 Phosphorylation HPRD   PhosphoSitePlus 18083107
S150 Phosphorylation HPRD 16825425
Y154 Phosphorylation PhosphoSitePlus
S172 Phosphorylation HPRD 16825425
Y178 Phosphorylation PhosphoSitePlus
K181 Acetylation PhosphoSitePlus
T182 Phosphorylation HPRD 16825425
S209 Phosphorylation HPRD 16825425
Y215 Phosphorylation PhosphoSitePlus
S261 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y265 Phosphorylation PhosphoSitePlus
S266 Phosphorylation PhosphoSitePlus
S285 Phosphorylation PhosphoSitePlus
T286 Phosphorylation PhosphoSitePlus
Y297 Phosphorylation HPRD   PhosphoSitePlus 16212419
S308 Phosphorylation HPRD 20068231, 16825425
S311 Phosphorylation HPRD 16825425
T362 Phosphorylation HPRD 19413330, 18691976, 18491316, ...18088087, 18212344, 19562805, 18767875, 18077418, 20058876, 19664995, 19651622, 17322306, 18669648, 20166139, 17287340, 19415658, 20068231
T364 Phosphorylation HPRD   PhosphoSitePlus 19413330, 18691976, 18491316, ...17287340, 18767875, 18077418, 15302935, 19664995, 15144186, 18452278, 19651622, 19664994, 18669648, 20058876, 18707149, 20166139, 18088087, 19415658, 20068231
S368 Phosphorylation HPRD   PhosphoSitePlus 19413330, 17287340, 16964243, ...18691976, 18767875, 18077418, 15302935, 19664995, 15144186, 18452278, 19651622, 19664994, 18669648, 18707149, 20166139, 18088087, 10537323, 19415658, 20068231, 18212344
T374 Phosphorylation HPRD 18691976, 18669648, 17081983
S380 Phosphorylation HPRD   PhosphoSitePlus 19413330, 18491316, 17287340, ...17081983, 18691976, 19664995, 18452278, 19651622, 18669648, 20166139, 20068231
S381 Phosphorylation HPRD   PhosphoSitePlus 19413330, 18491316, 18088087, ...16964243, 20230923, 18767875, 15302935, 19691289, 19664995, 19651622, 19664994, 18669648, 20058876, 18707149, 20166139, 18452278, 10537323, 19415658, 20068231, 18212344
Y384 Phosphorylation P12931 (SRC) , P16591 (FER) HPRD   PhosphoSitePlus 17016520, 17389395, 19413330, ...9748248, 18669648, 18491316, 17287340, 18707149, 18088087, 20068231, 16497976
S389 Phosphorylation HPRD 18669648, 17081983, 20068231
Y396 Phosphorylation HPRD   PhosphoSitePlus 17016520
Y409 Phosphorylation HPRD   PhosphoSitePlus 15951569, 17389395, 20068231, ...18707149
Y416 Phosphorylation HPRD   PhosphoSitePlus 16212419, 18707149
Y427 Phosphorylation PhosphoSitePlus
Y433 Phosphorylation P12931 (SRC) HPRD 9748248
Y449 Phosphorylation P12931 (SRC) HPRD 9748248


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047100 (hCTTN/Phos:2) pS113 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P53801 (PTTG1IP) Y174 Q14247 (CTTN) unknown eFIP 27603901
Phosphorylation Q14247 (CTTN) S418 O00401 (WASL) unknown eFIP 22952966
Phosphorylation Q14247 (CTTN) S418 Q9Y6W5 (WASF2) unknown eFIP 26490115
Phosphorylation Q14247 (CTTN) Y421 P53801 (PTTG1IP) decreased_association eFIP 27603901
Phosphorylation Q14247 (CTTN) S298 O43516 (WIPF1) inhibited_association eFIP 31727638


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S33 N33 Biomuta DOID:363 / uterine cancer [ tcga ]
K70 N70 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y104 C104 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S113 L113 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
K144 N144 Biomuta DOID:3571 / liver cancer [ icgc ]
S155 F155 Biomuta DOID:1324 / lung cancer [ tcga ]
Y162 C162 Biomuta DOID:11934 / head and neck cancer [ tcga ]
R168 * Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K171 N171 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S192 F192 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
K203 N203 Biomuta DOID:3571 / liver cancer [ icgc ]
T219 M219 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
R242 G242 Biomuta DOID:363 / uterine cancer [ tcga ]
K266 * Biomuta DOID:1324 / lung cancer [ tcga ]
K272 E272 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
K309 R309 Biomuta DOID:1115 / sarcoma [ tcga ]
K319 N319 Biomuta DOID:363 / uterine cancer [ tcga ]
T323 A323 Biomuta DOID:0070003 / blastoma [ cosmic ]
T399 M399 Biomuta DOID:363 / uterine cancer [ tcga ]
T401 M401 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:4362 / cervical cancer [ tcga ] DOID:1909 / melanoma [ cosmic ] DOID:0070003 / blastoma [ cosmic ]
T401 A401 Biomuta DOID:3070 / malignant glioma [ tcga ]
T411 I411 Biomuta DOID:1324 / lung cancer [ cosmic ]
S417 * Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S438 I438 Biomuta DOID:3571 / liver cancer [ icgc ]
S438 N438 Biomuta DOID:10283 / prostate cancer [ cosmic ]
T440 M440 Biomuta DOID:1612 / breast cancer [ icgc ]
R549 Q549 Biomuta DOID:10534 / stomach cancer [ tcga ] DOID:11934 / head and neck cancer [ tcga ]