Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14232 / EI2BA_HUMAN
Protein Name Translation initiation factor eIF-2B subunit alpha
Gene Name Name: EIF2B1
Synonyms:EIF2BA;
Organism Homo sapiens (Human)

PRO ID PR:Q14232
DAG View
PRO Name translation initiation factor eIF-2B subunit alpha (human)
Definition A translation initiation factor eIF-2B subunit alpha that is encoded in the genome of human.
Short Label hEIF2B1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14232 (EIF2B1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K11 Ubiquitination PhosphoSitePlus
K15 Ubiquitination PhosphoSitePlus
T29 Phosphorylation PhosphoSitePlus
K35 Acetylation PhosphoSitePlus   UniProt 19608861
K35 Ubiquitination PhosphoSitePlus
K38 Ubiquitination PhosphoSitePlus
Y83 Phosphorylation PhosphoSitePlus
S84 Phosphorylation PhosphoSitePlus
S105 Phosphorylation PhosphoSitePlus
S107 Phosphorylation PhosphoSitePlus
Y130 Phosphorylation PhosphoSitePlus
K145 Methylation PhosphoSitePlus
K145 Ubiquitination PhosphoSitePlus
S149 Phosphorylation PhosphoSitePlus
K163 Acetylation PhosphoSitePlus
K253 Ubiquitination PhosphoSitePlus
K258 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S105 Phosphorylation HPRD 20068231
S107 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T29 M29 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
T29 K29 Biomuta DOID:3571 / liver cancer [ icgc ]
T29 S29 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
K35 N35 Biomuta DOID:1324 / lung cancer [ tcga ]
S84 F84 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
K145 N145 Biomuta DOID:363 / uterine cancer [ tcga ]