iPTMnet Report for Q14209 (E2F2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14209 / E2F2_HUMAN
Protein Name Transcription factor E2F2
Gene Name Name: E2F2
Organism Homo sapiens (Human)

PRO ID PR:Q14209
DAG View
PRO Name transcription factor E2F2 (human)
Definition A transcription factor E2F2 that is encoded in the genome of human.
Short Label hE2F2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14209 (E2F2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T15 Phosphorylation PhosphoSitePlus
K88 Ubiquitination PhosphoSitePlus
T104 Phosphorylation PhosphoSitePlus
S117 Phosphorylation PhosphoSitePlus
K119 Acetylation PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
T120 Phosphorylation PhosphoSitePlus
K122 Acetylation PhosphoSitePlus
S123 Phosphorylation PhosphoSitePlus
K127 Acetylation PhosphoSitePlus
Y130 Phosphorylation HPRD   phospho.ELM 18669648
S133 Phosphorylation HPRD   phospho.ELM 18669648
K139 Ubiquitination PhosphoSitePlus
K187 Ubiquitination PhosphoSitePlus
K206 Ubiquitination PhosphoSitePlus
K236 Ubiquitination PhosphoSitePlus
K245 Acetylation PhosphoSitePlus
K262 Ubiquitination PhosphoSitePlus
K270 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K119 Acetylation PR:000027108 (h(CBP-p300)) PRO 10753885
K122 Acetylation PR:000027108 (h(CBP-p300)) PRO 10753885
K127 Acetylation PR:000027108 (h(CBP-p300)) PRO 10753885


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000028774 (hE2F2/iso:1/Ac:1) acK119,acK122,acK127 PR:000027108 (h(CBP-p300)) PRO 10753885


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T120 I120 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic, icgc ]
K122 N122 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K270 E270 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]