Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14204 / DYHC1_HUMAN
Protein Name Cytoplasmic dynein 1 heavy chain 1
Gene Name Name: DYNC1H1
Synonyms:DHC1,DNCH1,DNCL,DNECL,DYHC,KIAA0325;
Organism Homo sapiens (Human)

PRO ID PR:Q14204
DAG View
PRO Name cytoplasmic dynein 1 heavy chain 1 (human)
Definition A cytoplasmic dynein 1 heavy chain 1 that is encoded in the genome of human.
Short Label hDYNC1H1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14204 (DYNC1H1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 22223895
S2 Phosphorylation HPRD   PhosphoSitePlus 18491316
S13 Phosphorylation PhosphoSitePlus
K36 Acetylation PhosphoSitePlus
K36 Ubiquitination PhosphoSitePlus
K59 Ubiquitination PhosphoSitePlus
K67 Acetylation PhosphoSitePlus
K67 Ubiquitination PhosphoSitePlus
S70 Phosphorylation PhosphoSitePlus   UniProt 23186163
K85 Ubiquitination PhosphoSitePlus
K120 Ubiquitination PhosphoSitePlus
K129 Ubiquitination PhosphoSitePlus
S132 Phosphorylation PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
T240 Phosphorylation HPRD   PhosphoSitePlus 20068231
T260 O-Glycosylation GlyGen 23301498, 16408927, 26374642, ...29351928, 32119511, 29237092
T318 Phosphorylation PhosphoSitePlus
K337 Ubiquitination PhosphoSitePlus
S346 Phosphorylation PhosphoSitePlus
T348 Phosphorylation PhosphoSitePlus
T362 Phosphorylation PhosphoSitePlus
K371 Acetylation PhosphoSitePlus
K394 Acetylation PhosphoSitePlus
K394 Ubiquitination PhosphoSitePlus
K400 Ubiquitination PhosphoSitePlus
Y406 Phosphorylation PhosphoSitePlus
R477 Methylation PhosphoSitePlus
T489 Phosphorylation PhosphoSitePlus
S539 Phosphorylation PhosphoSitePlus
K540 Ubiquitination PhosphoSitePlus
K551 Ubiquitination PhosphoSitePlus
T574 Phosphorylation PhosphoSitePlus
K576 Ubiquitination PhosphoSitePlus
K613 Ubiquitination PhosphoSitePlus
K622 Acetylation PhosphoSitePlus
K622 Ubiquitination PhosphoSitePlus
K624 Ubiquitination PhosphoSitePlus
C633 S-Nitrosylation dbSNO 26338901
K634 Ubiquitination PhosphoSitePlus
K652 Ubiquitination PhosphoSitePlus
K671 Ubiquitination PhosphoSitePlus
K681 Ubiquitination PhosphoSitePlus
K683 Ubiquitination PhosphoSitePlus
S688 Phosphorylation HPRD   PhosphoSitePlus 19651622
K692 Acetylation PhosphoSitePlus
K692 Ubiquitination PhosphoSitePlus
T723 Phosphorylation PhosphoSitePlus
K734 Ubiquitination PhosphoSitePlus
K736 Acetylation PhosphoSitePlus
K736 Ubiquitination PhosphoSitePlus
S747 Phosphorylation HPRD 20068231
K748 Ubiquitination PhosphoSitePlus
K754 Acetylation PhosphoSitePlus
K754 Ubiquitination PhosphoSitePlus
K794 Acetylation PhosphoSitePlus
K809 Ubiquitination PhosphoSitePlus
S863 Phosphorylation HPRD 20068231
T866 Phosphorylation HPRD 20068231
Y869 Phosphorylation HPRD 20068231
K872 Ubiquitination PhosphoSitePlus
T873 Phosphorylation HPRD 20068231
R880 Methylation PhosphoSitePlus
K883 Acetylation PhosphoSitePlus
K956 Ubiquitination PhosphoSitePlus
Y970 Phosphorylation PhosphoSitePlus
K981 Ubiquitination PhosphoSitePlus
S995 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y1010 Phosphorylation PhosphoSitePlus
K1078 Ubiquitination PhosphoSitePlus
K1099 Ubiquitination PhosphoSitePlus
K1100 Ubiquitination PhosphoSitePlus
K1111 Ubiquitination PhosphoSitePlus
K1115 Ubiquitination PhosphoSitePlus
K1119 Ubiquitination PhosphoSitePlus
K1125 Acetylation PhosphoSitePlus   UniProt 19608861
K1125 Ubiquitination PhosphoSitePlus
K1130 Ubiquitination PhosphoSitePlus
S1137 Phosphorylation PhosphoSitePlus
S1157 Phosphorylation PhosphoSitePlus
S1164 Phosphorylation PhosphoSitePlus
T1168 Phosphorylation PhosphoSitePlus
Y1172 Phosphorylation PhosphoSitePlus
S1175 Phosphorylation PhosphoSitePlus
K1185 Acetylation PhosphoSitePlus
K1185 Ubiquitination PhosphoSitePlus
K1228 Ubiquitination PhosphoSitePlus
S1230 Phosphorylation PhosphoSitePlus
K1242 Ubiquitination PhosphoSitePlus
R1248 Methylation PhosphoSitePlus
T1259 Phosphorylation PhosphoSitePlus
Y1283 Phosphorylation PhosphoSitePlus
K1286 Acetylation PhosphoSitePlus
K1286 Ubiquitination PhosphoSitePlus
K1301 Ubiquitination PhosphoSitePlus
T1307 Phosphorylation PhosphoSitePlus
S1313 Phosphorylation PhosphoSitePlus
K1330 Ubiquitination PhosphoSitePlus
K1347 Ubiquitination PhosphoSitePlus
K1371 Acetylation PhosphoSitePlus
K1371 Methylation PhosphoSitePlus
K1371 Ubiquitination PhosphoSitePlus
R1378 Methylation PhosphoSitePlus
K1414 Ubiquitination PhosphoSitePlus
K1483 Ubiquitination PhosphoSitePlus
K1496 Ubiquitination PhosphoSitePlus
K1498 Ubiquitination PhosphoSitePlus
K1508 Ubiquitination PhosphoSitePlus
K1584 Ubiquitination PhosphoSitePlus
Y1618 Phosphorylation PhosphoSitePlus
S1624 Phosphorylation HPRD 20068231
K1649 Acetylation PhosphoSitePlus
K1649 Ubiquitination PhosphoSitePlus
K1697 Ubiquitination PhosphoSitePlus
Y1738 Phosphorylation PhosphoSitePlus
K1807 Acetylation PhosphoSitePlus
K1807 Ubiquitination PhosphoSitePlus
T1822 Phosphorylation PhosphoSitePlus
S1824 Phosphorylation PhosphoSitePlus
S1828 O-Glycosylation GlyGen 23301498, 16408927, 26374642, ...29351928, 32119511, 29237092
K1834 Ubiquitination PhosphoSitePlus
S1835 O-Glycosylation GlyGen 23301498, 16408927, 26374642, ...29351928, 32119511, 29237092
S1835 Phosphorylation PhosphoSitePlus
S1840 Phosphorylation PhosphoSitePlus
T1851 Phosphorylation PhosphoSitePlus
K1878 Ubiquitination PhosphoSitePlus
T1882 Phosphorylation PhosphoSitePlus
T1885 Phosphorylation PhosphoSitePlus
R1887 Methylation PhosphoSitePlus
S1903 Phosphorylation PhosphoSitePlus
K1912 Ubiquitination PhosphoSitePlus
K1917 Ubiquitination PhosphoSitePlus
K1992 Ubiquitination PhosphoSitePlus
S1994 Phosphorylation HPRD 20068231
C1999 S-Nitrosylation dbSNO 2212679, 22126794, 26338901
K2004 Ubiquitination PhosphoSitePlus
K2033 Ubiquitination PhosphoSitePlus
T2042 Phosphorylation PhosphoSitePlus
Y2055 Phosphorylation HPRD 20068231
K2068 Ubiquitination PhosphoSitePlus
K2094 Ubiquitination PhosphoSitePlus
S2095 Phosphorylation PhosphoSitePlus
S2099 Phosphorylation PhosphoSitePlus
K2104 Ubiquitination PhosphoSitePlus
S2231 Phosphorylation PhosphoSitePlus
K2239 Ubiquitination PhosphoSitePlus
K2257 Ubiquitination PhosphoSitePlus
K2261 Ubiquitination PhosphoSitePlus
Y2265 Phosphorylation PhosphoSitePlus
T2267 Phosphorylation PhosphoSitePlus
T2272 Phosphorylation PhosphoSitePlus
R2273 Methylation PhosphoSitePlus
T2276 Phosphorylation PhosphoSitePlus
T2281 Phosphorylation PhosphoSitePlus
K2349 Ubiquitination PhosphoSitePlus
S2384 Phosphorylation PhosphoSitePlus
K2401 Ubiquitination PhosphoSitePlus
S2410 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983
S2429 Phosphorylation PhosphoSitePlus
S2503 Phosphorylation PhosphoSitePlus
Y2517 Phosphorylation PhosphoSitePlus
S2546 Phosphorylation PhosphoSitePlus
T2559 Phosphorylation PhosphoSitePlus
K2561 Ubiquitination PhosphoSitePlus
T2695 Phosphorylation PhosphoSitePlus
K2702 Ubiquitination PhosphoSitePlus
K2721 Ubiquitination PhosphoSitePlus
Y2735 Phosphorylation PhosphoSitePlus
S2743 Phosphorylation PhosphoSitePlus
T2745 Phosphorylation PhosphoSitePlus
T2750 Phosphorylation PhosphoSitePlus
S2761 Phosphorylation HPRD 18691976, 20068231
T2770 Phosphorylation PhosphoSitePlus
Y2777 Phosphorylation PhosphoSitePlus
S2795 Phosphorylation PhosphoSitePlus
R2836 Methylation PhosphoSitePlus
R2843 Methylation PhosphoSitePlus
K2856 Ubiquitination PhosphoSitePlus
K2865 Ubiquitination PhosphoSitePlus
K2879 Ubiquitination PhosphoSitePlus
Y2881 Phosphorylation PhosphoSitePlus
Y2892 Phosphorylation PhosphoSitePlus
K2966 Acetylation PhosphoSitePlus
K2966 Ubiquitination PhosphoSitePlus
S2997 Phosphorylation PhosphoSitePlus
K3039 Ubiquitination PhosphoSitePlus
Y3051 Phosphorylation PhosphoSitePlus
K3076 Ubiquitination PhosphoSitePlus
S3082 Phosphorylation PhosphoSitePlus
Y3103 Phosphorylation PhosphoSitePlus
K3112 Ubiquitination PhosphoSitePlus
K3117 Ubiquitination PhosphoSitePlus
Y3125 Phosphorylation PhosphoSitePlus
Y3130 Phosphorylation PhosphoSitePlus
K3207 Sumoylation PhosphoSitePlus
K3209 Ubiquitination PhosphoSitePlus
R3219 Methylation PhosphoSitePlus
K3225 Ubiquitination PhosphoSitePlus
K3253 Ubiquitination PhosphoSitePlus
S3257 Phosphorylation PhosphoSitePlus
K3284 Ubiquitination PhosphoSitePlus
K3301 Ubiquitination PhosphoSitePlus
S3309 Phosphorylation HPRD   PhosphoSitePlus 20068231
S3323 Phosphorylation PhosphoSitePlus
K3369 Ubiquitination PhosphoSitePlus
Y3377 Phosphorylation PhosphoSitePlus
Y3379 Phosphorylation PhosphoSitePlus
S3386 Phosphorylation PhosphoSitePlus
K3407 Ubiquitination PhosphoSitePlus
K3418 Ubiquitination PhosphoSitePlus
K3429 Ubiquitination PhosphoSitePlus
S3443 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y3447 Phosphorylation PhosphoSitePlus
Y3451 Phosphorylation PhosphoSitePlus
K3462 Ubiquitination PhosphoSitePlus
K3471 Ubiquitination PhosphoSitePlus
S3475 Phosphorylation PhosphoSitePlus
T3476 Phosphorylation PhosphoSitePlus
K3480 Acetylation PhosphoSitePlus   UniProt 19608861
K3480 Ubiquitination PhosphoSitePlus
K3491 Ubiquitination PhosphoSitePlus
T3531 O-Glycosylation GlyGen 23301498, 16408927, 26374642, ...29351928, 32119511, 29237092
S3533 O-Glycosylation GlyGen 23301498, 16408927, 26374642, ...29351928, 32119511, 29237092
Y3552 Phosphorylation PhosphoSitePlus
S3554 Phosphorylation PhosphoSitePlus
K3581 Ubiquitination PhosphoSitePlus
K3605 Ubiquitination PhosphoSitePlus
K3621 Ubiquitination PhosphoSitePlus
S3640 Phosphorylation PhosphoSitePlus
S3706 Phosphorylation PhosphoSitePlus
K3718 Ubiquitination PhosphoSitePlus
K3727 Acetylation PhosphoSitePlus
S3729 Phosphorylation HPRD 20068231
K3747 Ubiquitination PhosphoSitePlus
S3748 Phosphorylation PhosphoSitePlus
K3757 Ubiquitination PhosphoSitePlus
K3774 Acetylation PhosphoSitePlus
K3774 Ubiquitination PhosphoSitePlus
K3893 Ubiquitination PhosphoSitePlus
S3917 Phosphorylation PhosphoSitePlus
T3921 Phosphorylation PhosphoSitePlus
K3945 Ubiquitination PhosphoSitePlus
K4089 Ubiquitination PhosphoSitePlus
K4111 Ubiquitination PhosphoSitePlus
T4127 Phosphorylation HPRD   PhosphoSitePlus 20068231
K4154 Ubiquitination PhosphoSitePlus
S4162 Phosphorylation PhosphoSitePlus   UniProt 23186163
K4171 Ubiquitination PhosphoSitePlus
K4204 Acetylation PhosphoSitePlus
K4204 Ubiquitination PhosphoSitePlus
K4228 Ubiquitination PhosphoSitePlus
S4234 Phosphorylation PhosphoSitePlus
K4237 Ubiquitination PhosphoSitePlus
S4241 Phosphorylation PhosphoSitePlus
T4274 Phosphorylation PhosphoSitePlus
S4277 Phosphorylation PhosphoSitePlus
S4280 Phosphorylation PhosphoSitePlus
K4283 Acetylation PhosphoSitePlus   UniProt 19608861
K4283 Ubiquitination PhosphoSitePlus
K4287 Ubiquitination PhosphoSitePlus
K4292 Ubiquitination PhosphoSitePlus
S4341 Phosphorylation PhosphoSitePlus
K4342 Ubiquitination PhosphoSitePlus
K4345 Ubiquitination PhosphoSitePlus
K4362 Ubiquitination PhosphoSitePlus
T4364 Phosphorylation HPRD   PhosphoSitePlus 20068231
T4366 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 23186163
S4368 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18452278, ...17322306, 18669648, 19415658, 20068231
T4369 Phosphorylation HPRD   PhosphoSitePlus 20068231
S4370 Phosphorylation HPRD   PhosphoSitePlus 18452278
K4406 Ubiquitination PhosphoSitePlus
K4441 Ubiquitination PhosphoSitePlus
K4457 Ubiquitination PhosphoSitePlus
K4487 Ubiquitination PhosphoSitePlus
S4493 Phosphorylation PhosphoSitePlus
K4502 Ubiquitination PhosphoSitePlus
K4505 Ubiquitination PhosphoSitePlus
S4582 Phosphorylation PhosphoSitePlus
T4583 Phosphorylation PhosphoSitePlus
T4588 Phosphorylation PhosphoSitePlus
K4594 Ubiquitination PhosphoSitePlus
S4603 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y4610 Phosphorylation PhosphoSitePlus
T4614 Phosphorylation HPRD   PhosphoSitePlus 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S70 A70 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
T318 N318 Biomuta DOID:3070 / malignant glioma [ tcga ]
K371 T371 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
Y869 H869 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
K1099 N1099 Biomuta DOID:363 / uterine cancer [ tcga ]
S1157 A1157 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
R1248 W1248 Biomuta DOID:363 / uterine cancer [ tcga ]
K1301 Q1301 Biomuta DOID:263 / kidney cancer [ cosmic ]
R1378 * Biomuta DOID:1793 / pancreatic cancer [ tcga ] DOID:363 / uterine cancer [ tcga ]
K1584 R1584 Biomuta DOID:1612 / breast cancer [ tcga ]
T1885 I1885 Biomuta DOID:9256 / colorectal cancer [ icgc ]
R1887 C1887 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
R1887 H1887 Biomuta DOID:363 / uterine cancer [ tcga ]
K2257 R2257 Biomuta DOID:9256 / colorectal cancer [ tcga ]
R2273 K2273 Biomuta DOID:10283 / prostate cancer [ cosmic ]
T2281 K2281 Biomuta DOID:1324 / lung cancer [ tcga ]
K2401 N2401 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S2410 F2410 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
T2559 M2559 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:1324 / lung cancer [ tcga ]
K2561 T2561 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K3112 E3112 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
Y3130 C3130 Biomuta DOID:2531 / hematologic cancer [ icgc ]
K3207 N3207 Biomuta DOID:3571 / liver cancer [ icgc ]
K3207 E3207 Biomuta DOID:363 / uterine cancer [ tcga ]
K3209 N3209 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
R3219 C3219 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
K3225 N3225 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
K3253 N3253 Biomuta DOID:3571 / liver cancer [ tcga ]
S3257 I3257 Biomuta DOID:3571 / liver cancer [ icgc ]
S3323 F3323 Biomuta DOID:2531 / hematologic cancer [ tcga ]
K3369 N3369 Biomuta DOID:1324 / lung cancer [ tcga ]
S3386 T3386 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K3480 N3480 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S3640 T3640 Biomuta DOID:1115 / sarcoma [ tcga ]
K3774 N3774 Biomuta DOID:1793 / pancreatic cancer [ icgc, tcga ] DOID:10283 / prostate cancer [ cosmic ]
K4228 M4228 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K4345 N4345 Biomuta DOID:363 / uterine cancer [ tcga ]