iPTMnet Report for Q14197 (MRPL58)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14197 / ICT1_HUMAN
Protein Name Large ribosomal subunit protein mL62 precursor
Gene Name Name: MRPL58
Synonyms:DS1,ICT1;
Organism Homo sapiens (Human)

PRO ID PR:Q14197
DAG View
PRO Name peptidyl-tRNA hydrolase ICT1, mitochondrial (human)
Definition An immature colon carcinoma transcript 1 protein that is encoded in the genome of human.
Short Label hMRPL58
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14197 (MRPL58) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y43 Phosphorylation PhosphoSitePlus
S44 Phosphorylation PhosphoSitePlus
K47 Ubiquitination PhosphoSitePlus
Y49 Phosphorylation PhosphoSitePlus
K66 Ubiquitination PhosphoSitePlus
S70 Phosphorylation PhosphoSitePlus
R76 Methylation PhosphoSitePlus
S84 Phosphorylation PhosphoSitePlus
S85 Phosphorylation PhosphoSitePlus
Q90 Methylation UniProt 35260756
S97 Phosphorylation PhosphoSitePlus
T159 Phosphorylation PhosphoSitePlus
S162 Phosphorylation PhosphoSitePlus
T164 Phosphorylation PhosphoSitePlus
T169 Phosphorylation HPRD   PhosphoSitePlus 17924679


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y43 * Biomuta DOID:1612 / breast cancer [ cosmic ]
R76 C76 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R76 H76 Biomuta DOID:363 / uterine cancer [ icgc ]
Q90 H90 Biomuta DOID:9256 / colorectal cancer [ cosmic ]