Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14195 / DPYL3_HUMAN
Protein Name Dihydropyrimidinase-related protein 3
Gene Name Name: DPYSL3
Synonyms:CRMP4,DRP3,ULIP,ULIP1;
Organism Homo sapiens (Human)

PRO ID PR:Q14195
DAG View
PRO Name dihydropyrimidinase-related protein 3 (human)
Definition A dihydropyrimidinase-related protein 3 that is encoded in the genome of human.
Short Label hDPYSL3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14195 (DPYSL3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO
S2 Phosphorylation PhosphoSitePlus
T13 Phosphorylation PhosphoSitePlus
S14 Phosphorylation PhosphoSitePlus
S30 Phosphorylation PhosphoSitePlus
Y32 Phosphorylation PhosphoSitePlus
Y251 Phosphorylation PhosphoSitePlus
T253 Phosphorylation PhosphoSitePlus
S257 Phosphorylation PhosphoSitePlus
S259 Phosphorylation PhosphoSitePlus   UniProt 21406692
S265 Phosphorylation PhosphoSitePlus
S282 Phosphorylation PhosphoSitePlus
S304 Phosphorylation PhosphoSitePlus
S308 Phosphorylation PhosphoSitePlus
K345 Ubiquitination PhosphoSitePlus
K374 Ubiquitination PhosphoSitePlus
S385 Phosphorylation PhosphoSitePlus
K398 Acetylation PhosphoSitePlus
S402 Phosphorylation PhosphoSitePlus
Y431 Phosphorylation PhosphoSitePlus
T462 Phosphorylation PhosphoSitePlus
S472 Phosphorylation PhosphoSitePlus
Y499 Phosphorylation PhosphoSitePlus
T507 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
T508 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
T509 Phosphorylation Q00535 (CDK5) , Q92630 (DYRK2) , P49841 (GSK3B) , P24941 (CDK2) PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21406692, 15466863, 18847512, ...20831597, 16611631, 24275569
K511 Ubiquitination PhosphoSitePlus
T514 Phosphorylation P49841 (GSK3B) , Q92630 (DYRK2) , Q00535 (CDK5) PRO   PhosphoSitePlus   Signor   UniProt 21406692, 15466863, 16611631
S518 Phosphorylation Q00535 (CDK5) , Q92630 (DYRK2) , P49841 (GSK3B) PRO   PhosphoSitePlus   Signor   UniProt 15466863, 16611631
R520 Methylation PhosphoSitePlus
S522 Phosphorylation Q92630 (DYRK2) , Q00535 (CDK5) neXtProt   PRO   PhosphoSitePlus   UniProt 21406692, 15466863, 16611631, ...24275569, 26555036
T524 Phosphorylation PhosphoSitePlus
S536 Phosphorylation PhosphoSitePlus
S539 Phosphorylation PhosphoSitePlus
S541 Phosphorylation PhosphoSitePlus
T543 Phosphorylation PhosphoSitePlus
S551 Phosphorylation PhosphoSitePlus
R563 Methylation PhosphoSitePlus
S564 Phosphorylation PhosphoSitePlus
T567 Phosphorylation PhosphoSitePlus
S568 Phosphorylation PhosphoSitePlus
S570 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T508 Phosphorylation HPRD 20058876
T509 Phosphorylation HPRD 17322306, 18212344, 20058876, ...19664994, 18452278, 19651622
T514 Phosphorylation HPRD 19651622
S518 Phosphorylation HPRD 19651622
S522 Phosphorylation HPRD 19651622, 18578522, 17081983
T524 Phosphorylation HPRD 19651622
S551 Phosphorylation HPRD 17081983
Site PTM Type PTM Enzyme Score Source PMID
S10 Phosphorylation PhosphoSitePlus
Y19 Phosphorylation PhosphoSitePlus
K48 Acetylation PhosphoSitePlus
T49 Phosphorylation PhosphoSitePlus
S56 Phosphorylation PhosphoSitePlus
R60 Methylation PhosphoSitePlus
T64 Phosphorylation PhosphoSitePlus
R73 Methylation PhosphoSitePlus
S75 Phosphorylation PhosphoSitePlus
S77 Phosphorylation PhosphoSitePlus
T85 Phosphorylation PhosphoSitePlus
S95 Phosphorylation PhosphoSitePlus
S102 Phosphorylation PhosphoSitePlus
S112 Phosphorylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047207 (hDPYSL3/Phos:1) pS522 PRO
PR:000047208 (hDPYSL3/Phos:2) pT509,pT514,pS518,pS522 PRO
PR:000047209 (hDPYSL3/PhosTyr+) p PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T462 S462 Biomuta DOID:0070003 / blastoma [ cosmic ]
T507 I507 Biomuta DOID:363 / uterine cancer [ tcga ]
T509 N509 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
R520 W520 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
S541 P541 Biomuta DOID:2531 / hematologic cancer [ icgc ]
R563 L563 Biomuta DOID:5041 / esophageal cancer [ icgc ]