iPTMnet Report for Q14195 (DPYSL3)
Protein Information
UniProt AC / UniProt ID | Q14195 / DPYL3_HUMAN |
Protein Name | Dihydropyrimidinase-related protein 3 |
Gene Name | Name: DPYSL3 Synonyms:CRMP4,DRP3,ULIP,ULIP1; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q14195 |
PRO Name | dihydropyrimidinase-related protein 3 (human) |
Definition | A dihydropyrimidinase-related protein 3 that is encoded in the genome of human. |
Short Label | hDPYSL3 |
Category | organism-gene |
Q14195 (DPYSL3) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
Phosphorylation | score1 | PRO | ||||
S2 | Phosphorylation | score1 | PhosphoSitePlus | |||
T13 | Phosphorylation | score1 | PhosphoSitePlus | |||
S14 | Phosphorylation | score1 | PhosphoSitePlus | |||
S30 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y32 | Phosphorylation | score1 | PhosphoSitePlus | |||
T102 | Phosphorylation | score1 | UniProt | 21406692, 17081983, 24275569 | ||
C248 | Methylation | score1 | IEDB | 31844290 | ||
Y251 | Phosphorylation | score1 | PhosphoSitePlus | |||
T253 | Phosphorylation | score1 | PhosphoSitePlus | |||
S257 | Phosphorylation | score1 | PhosphoSitePlus | |||
S259 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 21406692 | ||
S265 | Phosphorylation | score1 | PhosphoSitePlus | |||
S282 | Phosphorylation | score1 | PhosphoSitePlus | |||
S304 | Phosphorylation | score1 | PhosphoSitePlus | |||
S308 | Phosphorylation | score1 | PhosphoSitePlus | |||
K345 | Ubiquitination | score1 | PhosphoSitePlus | |||
K374 | Sumoylation | score1 | PhosphoSitePlus | |||
K374 | Ubiquitination | score1 | PhosphoSitePlus | |||
S385 | Phosphorylation | score1 | PhosphoSitePlus | |||
K398 | Acetylation | score1 | PhosphoSitePlus | |||
S402 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y431 | Phosphorylation | score1 | PhosphoSitePlus | |||
C448 | Methylation | score1 | IEDB | 31844290 | ||
T462 | Phosphorylation | score1 | PhosphoSitePlus | |||
S472 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y499 | Phosphorylation | score1 | PhosphoSitePlus | |||
T507 | Phosphorylation | P24941 (CDK2) | score1 | PhosphoSitePlus | 18847512 | |
T508 | Phosphorylation | P24941 (CDK2) | score1 | PhosphoSitePlus | 18847512 | |
T509 | Phosphorylation | Q00535 (CDK5) , Q92630 (DYRK2) , P49841 (GSK3B) , P24941 (CDK2) | score4 | PRO PhosphoSitePlus RLIMS-P Signor UniProt | 21406692, 33893293, 15466863, ... | |
K511 | Ubiquitination | score1 | PhosphoSitePlus | |||
T514 | Phosphorylation | P49841 (GSK3B) , Q92630 (DYRK2) , Q00535 (CDK5) | score4 | PRO PhosphoSitePlus RLIMS-P Signor UniProt | 21406692, 15466863, 33893293, ... | |
S518 | Phosphorylation | Q00535 (CDK5) , Q92630 (DYRK2) , P49841 (GSK3B) | score4 | PRO PhosphoSitePlus RLIMS-P Signor UniProt | 15466863, 33893293, 16611631 | |
R520 | Methylation | score1 | PhosphoSitePlus | |||
S522 | Phosphorylation | Q92630 (DYRK2) , Q00535 (CDK5) | score4 | neXtProt PRO PhosphoSitePlus RLIMS-P UniProt | 21406692, 33893293, 15466863, ... | |
T524 | Phosphorylation | score1 | PhosphoSitePlus | |||
S536 | Phosphorylation | score1 | PhosphoSitePlus | |||
S539 | Phosphorylation | score1 | PhosphoSitePlus | |||
S541 | Phosphorylation | score1 | PhosphoSitePlus | |||
T543 | Phosphorylation | score1 | PhosphoSitePlus | |||
S551 | Phosphorylation | score1 | PhosphoSitePlus | |||
R563 | Methylation | score1 | PhosphoSitePlus | |||
S564 | Phosphorylation | score1 | PhosphoSitePlus | |||
T567 | Phosphorylation | score1 | PhosphoSitePlus | |||
S568 | Phosphorylation | score1 | PhosphoSitePlus | |||
S570 | Phosphorylation | score1 | PhosphoSitePlus |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
T508 | Phosphorylation | score0 | HPRD | 20058876 | ||
T509 | Phosphorylation | score0 | HPRD | 17322306, 18212344, 20058876, ... | ||
T514 | Phosphorylation | score0 | HPRD | 19651622 | ||
S518 | Phosphorylation | score0 | HPRD | 19651622 | ||
S522 | Phosphorylation | score0 | HPRD | 19651622, 18578522, 17081983 | ||
T524 | Phosphorylation | score0 | HPRD | 19651622 | ||
S551 | Phosphorylation | score0 | HPRD | 17081983 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S10 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y19 | Phosphorylation | score1 | PhosphoSitePlus | |||
K48 | Acetylation | score1 | PhosphoSitePlus | |||
T49 | Phosphorylation | score1 | PhosphoSitePlus | |||
S56 | Phosphorylation | score1 | PhosphoSitePlus | |||
R60 | Methylation | score1 | PhosphoSitePlus | |||
T64 | Phosphorylation | score1 | PhosphoSitePlus | |||
R73 | Methylation | score1 | PhosphoSitePlus | |||
S75 | Phosphorylation | score1 | PhosphoSitePlus | |||
S77 | Phosphorylation | score1 | PhosphoSitePlus | |||
T85 | Phosphorylation | score1 | PhosphoSitePlus | |||
S95 | Phosphorylation | score1 | PhosphoSitePlus | |||
S102 | Phosphorylation | score1 | PhosphoSitePlus | |||
S112 | Phosphorylation | score1 | PhosphoSitePlus |
Proteoforms
PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID | |
---|---|---|---|---|---|
PR:000047207 (hDPYSL3/Phos:1) | pS522 | PRO | |||
PR:000047208 (hDPYSL3/Phos:2) | pT509,pT514,pS518,pS522 | PRO | |||
PR:000047209 (hDPYSL3/PhosTyr+) | p | PRO |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
R60 | Q60 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
R73 | Q73 | Biomuta | DOID:5041 / esophageal cancer [ cosmic ] | |
T85 | I85 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
T102 | A102 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
S102 | P102 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
T462 | S462 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
T507 | I507 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
T509 | N509 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
R520 | Q520 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
R520 | W520 | Biomuta | DOID:4362 / cervical cancer [ cosmic, icgc ] | |
S522 | C522 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic ] | |
S522 | F522 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
S541 | P541 | Biomuta | DOID:2531 / hematologic cancer [ cosmic, icgc ] | |
R563 | L563 | Biomuta | DOID:5041 / esophageal cancer [ cosmic, icgc ] |