iPTMnet Report for Q14191 (WRN)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14191 / WRN_HUMAN
Protein Name Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN
Gene Name Name: WRN
Synonyms:RECQ3,RECQL2;
Organism Homo sapiens (Human)

PRO ID PR:Q14191
DAG View
PRO Name bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (human)
Definition A bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN that is encoded in the genome of human.
Short Label hWRN
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14191 (WRN) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 22814378
K5 Ubiquitination PhosphoSitePlus
K14 Ubiquitination PhosphoSitePlus
K32 Acetylation PhosphoSitePlus
K131 Ubiquitination PhosphoSitePlus
K135 Ubiquitination PhosphoSitePlus
K146 Ubiquitination PhosphoSitePlus
K154 Ubiquitination PhosphoSitePlus
K167 Ubiquitination PhosphoSitePlus
K187 Ubiquitination PhosphoSitePlus
K202 Ubiquitination PhosphoSitePlus
K241 Sumoylation PhosphoSitePlus
K241 Ubiquitination PhosphoSitePlus
S248 Phosphorylation PhosphoSitePlus
S282 Phosphorylation PhosphoSitePlus
K286 Ubiquitination PhosphoSitePlus
S319 Phosphorylation P78527 (PRKDC) neXtProt   PhosphoSitePlus 20516064
K356 Sumoylation PRO
K366 Acetylation PhosphoSitePlus
K366 Ubiquitination PhosphoSitePlus
K382 Ubiquitination PhosphoSitePlus
S409 Phosphorylation PhosphoSitePlus
S426 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332, 18452278
S435 Phosphorylation PhosphoSitePlus
S440 Phosphorylation P78527 (PRKDC) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18669648, 19690332, 24429382, ...18452278
S453 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
S462 Phosphorylation PhosphoSitePlus
S467 Phosphorylation P78527 (PRKDC) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18669648, 19690332, 24429382
S478 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 23186163, 24429382
K493 Acetylation PhosphoSitePlus
K493 Ubiquitination PhosphoSitePlus
K496 Sumoylation PRO   PhosphoSitePlus
K506 Ubiquitination PhosphoSitePlus
S689 Phosphorylation PhosphoSitePlus
T692 Phosphorylation PhosphoSitePlus
K775 Ubiquitination PhosphoSitePlus
T777 Phosphorylation PhosphoSitePlus
S790 Phosphorylation PhosphoSitePlus
S801 Phosphorylation PhosphoSitePlus
Y849 Phosphorylation PhosphoSitePlus
K887 Acetylation PhosphoSitePlus
K898 Sumoylation PRO
K924 Ubiquitination PhosphoSitePlus
K934 Ubiquitination PhosphoSitePlus
S948 Phosphorylation PhosphoSitePlus
S968 Phosphorylation PhosphoSitePlus
K1036 Sumoylation PhosphoSitePlus
S1058 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17525332
K1073 Ubiquitination PhosphoSitePlus
S1079 Phosphorylation PhosphoSitePlus
K1080 Ubiquitination PhosphoSitePlus
S1084 Phosphorylation PhosphoSitePlus
K1087 Ubiquitination PhosphoSitePlus
T1100 Phosphorylation PhosphoSitePlus
K1102 Ubiquitination PhosphoSitePlus
Y1110 Phosphorylation PhosphoSitePlus
S1111 Phosphorylation PhosphoSitePlus
Y1112 Phosphorylation HPRD   PhosphoSitePlus 18452278
K1117 Acetylation PhosphoSitePlus
S1120 Phosphorylation HPRD   PhosphoSitePlus 18452278
K1127 Acetylation PhosphoSitePlus
S1128 Phosphorylation PhosphoSitePlus
S1133 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P   UniProt 19413330, 21406692, 23186163, ...19664994, 27634057, 31141682
S1139 Phosphorylation RLIMS-P 31141682
S1140 Phosphorylation RLIMS-P 31141682
S1141 Phosphorylation Q13315 (ATM) , Q13535 (ATR) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 31141682, 17525332, 10608806, ...11252893, 26695548, 24429382, 10839545
K1170 Ubiquitination PhosphoSitePlus
K1189 Ubiquitination PhosphoSitePlus
K1199 Ubiquitination PhosphoSitePlus
S1205 Phosphorylation PhosphoSitePlus
T1236 Phosphorylation IEDB 35494241
K1270 Ubiquitination PhosphoSitePlus
K1274 Acetylation PhosphoSitePlus
S1279 Phosphorylation IEDB 35494241
S1292 Phosphorylation Q13535 (ATR) , Q13315 (ATM) HPRD   neXtProt   phospho.ELM 10608806
K1314 Ubiquitination PhosphoSitePlus
K1331 Ubiquitination PhosphoSitePlus
K1371 Ubiquitination PhosphoSitePlus
S1378 Phosphorylation PhosphoSitePlus
K1386 Ubiquitination PhosphoSitePlus
S1388 Phosphorylation PhosphoSitePlus
K1389 Acetylation PhosphoSitePlus
K1389 Ubiquitination PhosphoSitePlus
S1400 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
K1413 Acetylation PhosphoSitePlus
R1427 Methylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049701 (hWRN/Sumo:1) suK356,suK496,suK898 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q14191 (WRN) S1133 P49959 (MRE11) unknown eFIP 27634057


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 I2 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K5 I5 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
K5 * Biomuta DOID:10283 / prostate cancer [ cosmic ]
K32 R32 Biomuta DOID:10283 / prostate cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
K32 N32 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K154 E154 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K356 E356 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K382 T382 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K382 R382 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S440 N440 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S790 F790 Biomuta DOID:363 / uterine cancer [ icgc ]
S801 G801 Biomuta DOID:3571 / liver cancer [ cosmic ]
K924 T924 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K934 Q934 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S968 F968 Biomuta DOID:4159 / skin cancer [ cosmic ]
K1036 R1036 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1079 L1079 Biomuta [ cosmic ] DOID:10283 / prostate cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
S1084 L1084 Biomuta DOID:4159 / skin cancer [ cosmic ]
K1087 E1087 Biomuta [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
T1100 A1100 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y1110 * Biomuta DOID:363 / uterine cancer [ cosmic ]
K1117 Q1117 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
K1117 M1117 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
S1128 G1128 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S1140 P1140 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K1170 E1170 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
K1189 N1189 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S1205 F1205 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1279 N1279 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S1292 Y1292 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S1292 F1292 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1378 F1378 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1400 F1400 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]