iPTMnet Report for Q14166 (TTLL12)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14166 / TTL12_HUMAN
Protein Name Tubulin--tyrosine ligase-like protein 12
Gene Name Name: TTLL12
Synonyms:KIAA0153;
Organism Homo sapiens (Human)

PRO ID PR:Q14166
DAG View
PRO Name tubulin--tyrosine ligase-like protein 12 (human)
Definition A tubulin--tyrosine ligase-like protein 12 that is encoded in the genome of human.
Short Label hTTLL12
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14166 (TTLL12) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S15 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19413330, 20230923, 18669648, ...20166139, 20068231
S16 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19413330, 17081983, 20230923, ...18452278, 19651622, 18669648, 18707149, 20068231, 17924679
T20 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 17924679, 17081983, ...20230923
S42 Phosphorylation PhosphoSitePlus
K88 Ubiquitination PhosphoSitePlus
C98 S-Nitrosylation dbSNO 26338901
K100 Ubiquitination PhosphoSitePlus
K187 Ubiquitination PhosphoSitePlus
K253 Ubiquitination PhosphoSitePlus
K289 Ubiquitination PhosphoSitePlus
Y308 Phosphorylation PhosphoSitePlus
T309 Phosphorylation PhosphoSitePlus
T319 Phosphorylation PhosphoSitePlus
K342 Ubiquitination PhosphoSitePlus
K346 Sumoylation PhosphoSitePlus
K346 Ubiquitination PhosphoSitePlus
S348 Phosphorylation PhosphoSitePlus
C361 S-Nitrosylation dbSNO 19483679
K368 Ubiquitination PhosphoSitePlus
T395 Phosphorylation PhosphoSitePlus
S402 Phosphorylation PhosphoSitePlus
Y403 Phosphorylation PhosphoSitePlus
K419 Ubiquitination PhosphoSitePlus
S426 Phosphorylation PhosphoSitePlus
K433 Ubiquitination PhosphoSitePlus
S437 Phosphorylation PhosphoSitePlus
K447 Ubiquitination PhosphoSitePlus
K451 Ubiquitination PhosphoSitePlus
Y452 Phosphorylation PhosphoSitePlus
S455 Phosphorylation PhosphoSitePlus
Y508 Phosphorylation PhosphoSitePlus
K510 Ubiquitination PhosphoSitePlus
T513 Phosphorylation PhosphoSitePlus
Y517 Phosphorylation PhosphoSitePlus
K524 Ubiquitination PhosphoSitePlus
K565 Ubiquitination PhosphoSitePlus
C612 S-Nitrosylation dbSNO 26338901


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K253 R253 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
T309 M309 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T319 I319 Biomuta DOID:1324 / lung cancer [ cosmic ]
K433 N433 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S437 G437 Biomuta DOID:363 / uterine cancer [ icgc ]
T513 M513 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
Y517 F517 Biomuta DOID:4159 / skin cancer [ cosmic ]
C612 G612 Biomuta DOID:3571 / liver cancer [ cosmic ]