iPTMnet Report for Q14161 (GIT2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14161 / GIT2_HUMAN
Protein Name ARF GTPase-activating protein GIT2
Gene Name Name: GIT2
Synonyms:KIAA0148;
Organism Homo sapiens (Human)

PRO ID PR:Q14161
DAG View
PRO Name ARF GTPase-activating protein GIT2 (human)
Definition An ARF GTPase-activating protein GIT2 that is encoded in the genome of human.
Short Label hGIT2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14161 (GIT2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S7 Phosphorylation PhosphoSitePlus
S8 Phosphorylation PhosphoSitePlus
S36 Phosphorylation PhosphoSitePlus
K98 Ubiquitination PhosphoSitePlus
K103 Ubiquitination PhosphoSitePlus
S127 Phosphorylation PhosphoSitePlus
K131 Ubiquitination PhosphoSitePlus
K135 Ubiquitination PhosphoSitePlus
C149 Methylation IEDB 31844290
S154 Phosphorylation PhosphoSitePlus
T195 Phosphorylation Q13315 (ATM) PhosphoSitePlus 25605334
Y286 Phosphorylation RLIMS-P 23615439
S361 Phosphorylation PhosphoSitePlus
S365 Phosphorylation PhosphoSitePlus
K366 Ubiquitination PhosphoSitePlus
T375 Phosphorylation PhosphoSitePlus
S381 Phosphorylation HPRD   PhosphoSitePlus 18452278
S384 Phosphorylation Q13315 (ATM) HPRD   PhosphoSitePlus 25605334, 18452278
Y392 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 18669648, 23615439
S394 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332, 18452278
S397 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332, ...18452278
T401 Phosphorylation PhosphoSitePlus
T405 Phosphorylation PhosphoSitePlus
T406 Phosphorylation PhosphoSitePlus
S408 Phosphorylation PhosphoSitePlus
S415 Phosphorylation PhosphoSitePlus   UniProt 17081983, 24275569
S418 Phosphorylation PhosphoSitePlus   UniProt 17081983
S421 Phosphorylation PhosphoSitePlus   UniProt 17081983, 20068231
T426 Phosphorylation PhosphoSitePlus
K434 Ubiquitination PhosphoSitePlus
K443 Ubiquitination PhosphoSitePlus
K449 Ubiquitination PhosphoSitePlus
K464 Ubiquitination PhosphoSitePlus
K477 Ubiquitination PhosphoSitePlus
T480 Phosphorylation PhosphoSitePlus
T481 Phosphorylation PhosphoSitePlus
Y484 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15592455
T488 Phosphorylation phospho.ELM   PhosphoSitePlus 15144186
S490 Phosphorylation PhosphoSitePlus
Y492 Phosphorylation phospho.ELM   PhosphoSitePlus 15592455
T493 Phosphorylation PhosphoSitePlus
T495 Phosphorylation PhosphoSitePlus
S496 Phosphorylation phospho.ELM   PhosphoSitePlus 15144186
S500 Phosphorylation PhosphoSitePlus
S506 Phosphorylation PhosphoSitePlus
S510 Phosphorylation PhosphoSitePlus
S514 Phosphorylation PhosphoSitePlus
Y516 Phosphorylation PhosphoSitePlus
T518 Phosphorylation PhosphoSitePlus
S520 Phosphorylation PhosphoSitePlus
Y525 Phosphorylation PhosphoSitePlus
S532 Phosphorylation PhosphoSitePlus
S551 O-Glycosylation GlyGen 29351928, 31492838, 32938750, ...28657654, 35254053
T555 O-Glycosylation GlyGen 31492838, 29351928, 28657654, ...35254053
S556 O-Glycosylation GlyGen 31492838, 29351928, 28657654, ...35254053
S557 O-Glycosylation GlyGen 31492838, 29351928, 28657654, ...35254053
S557 Phosphorylation PhosphoSitePlus
S558 Phosphorylation PhosphoSitePlus
S559 O-Glycosylation GlyGen 31492838, 29351928, 28657654, ...35254053
S559 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19690332, 18220336
S562 Phosphorylation PhosphoSitePlus
S565 Phosphorylation PhosphoSitePlus
T566 O-Glycosylation GlyGen 31492838, 29351928, 28657654, ...35254053
S568 O-Glycosylation GlyGen 31492838, 29351928, 28657654, ...35254053
S568 Phosphorylation PhosphoSitePlus
S570 O-Glycosylation GlyGen 31492838, 29351928, 28657654, ...35254053
S570 Phosphorylation PhosphoSitePlus
S586 Phosphorylation PhosphoSitePlus
T587 Phosphorylation PhosphoSitePlus
S590 Phosphorylation PhosphoSitePlus
Y592 Phosphorylation PhosphoSitePlus   RLIMS-P 23615439
S614 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19690332, 18220336
S668 Phosphorylation PhosphoSitePlus
C672 Methylation IEDB 31844290
S673 Phosphorylation PhosphoSitePlus
S693 Phosphorylation PhosphoSitePlus
T698 Phosphorylation PhosphoSitePlus
S699 Phosphorylation PhosphoSitePlus
S724 Phosphorylation PhosphoSitePlus
Y740 Phosphorylation IEDB 35494241
K747 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S381 Phosphorylation HPRD 18452278
S384 Phosphorylation HPRD 18452278
Y392 Phosphorylation HPRD 18669648
S394 Phosphorylation HPRD 18669648, 18452278
S397 Phosphorylation HPRD 18669648, 18452278
S415 Phosphorylation HPRD 19651622, 20058876, 17081983, ...20068231
S418 Phosphorylation HPRD 19651622, 17081983
S421 Phosphorylation HPRD 19651622, 17081983, 20068231
Y484 Phosphorylation HPRD 15592455
T488 Phosphorylation HPRD 15144186
Y492 Phosphorylation HPRD 15592455
S496 Phosphorylation HPRD 15144186
S614 Phosphorylation HPRD 20068231
S724 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S258 Phosphorylation PhosphoSitePlus
S262 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S381 Phosphorylation HPRD 18452278
S384 Phosphorylation HPRD 18452278
Y392 Phosphorylation HPRD 18669648
S394 Phosphorylation HPRD 18669648, 18452278
S397 Phosphorylation HPRD 18669648, 18452278
S415 Phosphorylation HPRD 19651622, 20058876, 17081983, ...20068231
S418 Phosphorylation HPRD 19651622, 17081983
S421 Phosphorylation HPRD 19651622, 17081983, 20068231
S486 Phosphorylation HPRD 20068231
S596 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y286 * Biomuta DOID:10283 / prostate cancer [ cosmic ]
S361 F361 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
Y392 N392 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T401 K401 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T405 A405 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:4362 / cervical cancer [ cosmic, icgc ]
S421 L421 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
K477 N477 Biomuta DOID:4159 / skin cancer [ cosmic ]
T481 I481 Biomuta DOID:4159 / skin cancer [ cosmic ]
S490 P490 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
S568 F568 Biomuta DOID:4159 / skin cancer [ cosmic ]
S568 Y568 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S570 L570 Biomuta DOID:1324 / lung cancer [ cosmic ]
S596 L596 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S673 L673 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S693 C693 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S724 L724 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]