Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14160 / SCRIB_HUMAN
Protein Name Protein scribble homolog
Gene Name Name: SCRIB
Synonyms:CRIB1,KIAA0147,LAP4,SCRB1,VARTUL;
Organism Homo sapiens (Human)

PRO ID PR:Q14160
DAG View
PRO Name protein scribble homolog (human)
Definition A protein LAP4 that is encoded in the genome of human.
Short Label hSCRIB
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14160 (SCRIB) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K19 Ubiquitination PhosphoSitePlus
C22 S-Nitrosylation dbSNO 26338901
S23 Phosphorylation PhosphoSitePlus
Y32 Phosphorylation PhosphoSitePlus
Y34 Phosphorylation PhosphoSitePlus
S35 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983, 18220336
S37 Phosphorylation PhosphoSitePlus   UniProt 23186163
K53 Ubiquitination PhosphoSitePlus
K63 Ubiquitination PhosphoSitePlus
S67 Phosphorylation PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
K105 Ubiquitination PhosphoSitePlus
K164 Ubiquitination PhosphoSitePlus
S165 Phosphorylation PhosphoSitePlus
K266 Ubiquitination PhosphoSitePlus
K272 Ubiquitination PhosphoSitePlus
K313 Ubiquitination PhosphoSitePlus
T378 Phosphorylation PhosphoSitePlus   UniProt 23186163
K383 Methylation PhosphoSitePlus
S432 Phosphorylation PhosphoSitePlus
S446 Phosphorylation PhosphoSitePlus
K467 Ubiquitination PhosphoSitePlus
T475 Phosphorylation PhosphoSitePlus   UniProt 23186163
S487 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S493 Phosphorylation PhosphoSitePlus
S504 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 24275569, ...18220336
K512 Ubiquitination PhosphoSitePlus
S515 Phosphorylation PhosphoSitePlus
T553 Phosphorylation P27361 (MAPK3) neXtProt 20622900
Y564 Phosphorylation PhosphoSitePlus
T607 Phosphorylation PhosphoSitePlus
Y610 Phosphorylation PhosphoSitePlus
S668 Phosphorylation PhosphoSitePlus
S688 Phosphorylation PhosphoSitePlus   UniProt 21406692
T689 Phosphorylation PhosphoSitePlus   UniProt 21406692
S703 Phosphorylation PhosphoSitePlus
K705 Ubiquitination PhosphoSitePlus
S708 Phosphorylation PhosphoSitePlus   UniProt 23186163
T728 Phosphorylation PhosphoSitePlus
T730 Phosphorylation PhosphoSitePlus
T735 Phosphorylation PhosphoSitePlus
S741 Phosphorylation PhosphoSitePlus
S748 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 18220336
T749 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 18220336
Y751 Phosphorylation PhosphoSitePlus
K752 Ubiquitination PhosphoSitePlus
S761 Phosphorylation PhosphoSitePlus
S764 O-Glycosylation GlyGen 23301498, 32119511, 29351928
S764 Phosphorylation PhosphoSitePlus   UniProt 24275569
T824 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T826 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332, 20068231
Y834 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 18220336
S835 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231, 18220336
S853 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18220336, ...18669648, 24275569, 20068231
S868 Phosphorylation PhosphoSitePlus
S875 Phosphorylation PhosphoSitePlus   UniProt 23186163
K880 Ubiquitination PhosphoSitePlus
T883 Phosphorylation PhosphoSitePlus
R886 Methylation PhosphoSitePlus
S917 Phosphorylation PhosphoSitePlus
S939 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983, 20068231
T941 Phosphorylation PhosphoSitePlus
Y1000 Phosphorylation PhosphoSitePlus
S1017 Phosphorylation PhosphoSitePlus
K1040 Ubiquitination PhosphoSitePlus
S1050 Phosphorylation PhosphoSitePlus
K1105 Ubiquitination PhosphoSitePlus
S1114 Phosphorylation PhosphoSitePlus
R1116 Methylation PhosphoSitePlus
R1120 Methylation PhosphoSitePlus
K1138 Ubiquitination PhosphoSitePlus
S1140 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 15302935, 18669648, ...24275569, 20068231
S1220 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 15302935, ...15144186, 24275569, 19690332, 20068231
S1223 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S1225 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1226 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S1232 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
K1240 Ubiquitination PhosphoSitePlus
R1259 Methylation PhosphoSitePlus
K1265 Ubiquitination PhosphoSitePlus
Y1268 Phosphorylation PhosphoSitePlus
S1276 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1279 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1285 Phosphorylation PhosphoSitePlus
S1295 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1298 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983, 24275569
S1300 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1306 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17081983, ...24275569
S1309 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...15302935, 18669648, 24275569
T1342 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332, 20068231, ...17081983
S1348 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19369195, 23186163, 17081983, ...15302935, 18669648, 19690332, 20068231
S1353 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y1360 Phosphorylation PhosphoSitePlus
S1378 Phosphorylation Q13464 (ROCK1) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 23186163, 17081983, ...26101221, 18669648, 24275569, 20068231
S1437 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S1439 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1442 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1445 Phosphorylation P17612 (PRKACA) PhosphoSitePlus   RLIMS-P   Signor   UniProt 23359326, 24275569, 20622900
S1448 Phosphorylation P27361 (MAPK3) neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 19369195, 23186163, 17081983, ...20622900, 15302935, 18669648, 24275569, 20068231
T1460 Phosphorylation PhosphoSitePlus
S1475 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18220336, 15302935, ...18669648, 19690332, 20068231
S1486 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16964243, 15302935, ...18669648, 24275569, 20068231
K1507 Methylation PhosphoSitePlus
S1508 Phosphorylation Q13464 (ROCK1) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18669648, 23186163, 26101221, ...24275569
S1521 Phosphorylation PhosphoSitePlus
S1523 Phosphorylation PhosphoSitePlus
R1527 Methylation PhosphoSitePlus
T1529 Phosphorylation RLIMS-P 26101221
S1541 Phosphorylation PhosphoSitePlus   UniProt 23186163
T1545 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1547 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983, 19690332
T1549 Phosphorylation PhosphoSitePlus
T1558 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1559 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T1560 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1561 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 18220336
S1566 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18220336, ...15302935, 18669648, 24275569, 19690332, 20068231
S1579 Phosphorylation PhosphoSitePlus
S1581 Phosphorylation PhosphoSitePlus
S1600 Phosphorylation PhosphoSitePlus
S1613 Phosphorylation PhosphoSitePlus
R1623 Methylation PhosphoSitePlus
S1630 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T394 Phosphorylation PhosphoSitePlus
T668 Phosphorylation PhosphoSitePlus
Y919 Phosphorylation PhosphoSitePlus
S1204 Phosphorylation PhosphoSitePlus
Y1279 Phosphorylation PhosphoSitePlus
S1427 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T475 Phosphorylation PhosphoSitePlus
Y1000 Phosphorylation PhosphoSitePlus
S1285 Phosphorylation PhosphoSitePlus
Y1360 Phosphorylation PhosphoSitePlus
S1508 Phosphorylation PhosphoSitePlus
S1541 Phosphorylation PhosphoSitePlus
S1547 Phosphorylation PhosphoSitePlus
T1549 Phosphorylation PhosphoSitePlus
S1559 Phosphorylation PhosphoSitePlus
S1561 Phosphorylation PhosphoSitePlus
Y1587 Phosphorylation PhosphoSitePlus
S1591 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q14160 (SCRIB) S1508 Q13796 (SHROOM2) unknown eFIP 26101221


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
C22 Y22 Biomuta DOID:1909 / melanoma [ cosmic ]
S23 L23 Biomuta DOID:1324 / lung cancer [ tcga ]
S35 T35 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K53 * Biomuta DOID:1612 / breast cancer [ icgc ]
S165 P165 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
K467 M467 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
T553 A553 Biomuta DOID:2531 / hematologic cancer [ icgc ]
S708 L708 Biomuta DOID:363 / uterine cancer [ tcga ]
S875 C875 Biomuta DOID:9256 / colorectal cancer [ icgc ] DOID:263 / kidney cancer [ cosmic ]
T883 I883 Biomuta DOID:9256 / colorectal cancer [ tcga ]
R1116 C1116 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
S1225 C1225 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
S1226 F1226 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
R1259 W1259 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S1276 G1276 Biomuta DOID:1909 / melanoma [ cosmic ]
S1279 R1279 Biomuta DOID:10534 / stomach cancer [ icgc ] DOID:1324 / lung cancer [ tcga ]
S1306 P1306 Biomuta DOID:4159 / skin cancer [ icgc ]
T1460 M1460 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
S1523 Y1523 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
S1523 F1523 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
R1527 Q1527 Biomuta DOID:263 / kidney cancer [ cosmic ]
R1623 H1623 Biomuta DOID:9256 / colorectal cancer [ tcga ]