iPTMnet Report for Q14155 (ARHGEF7)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14155 / ARHG7_HUMAN
Protein Name Rho guanine nucleotide exchange factor 7
Gene Name Name: ARHGEF7
Synonyms:COOL1,KIAA0142,P85SPR,PAK3BP,PIXB;ORFNames:Nbla10314;
Organism Homo sapiens (Human)

PRO ID PR:Q14155
DAG View
PRO Name Rho guanine nucleotide exchange factor 7 (human)
Definition A Rho guanine nucleotide exchange factor 7 that is encoded in the genome of human.
Short Label hARHGEF7
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14155 (ARHGEF7) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
N2 Acetylation UniProt 22223895
S25 Phosphorylation PhosphoSitePlus
S123 Phosphorylation PhosphoSitePlus
S124 Phosphorylation PhosphoSitePlus
T127 Phosphorylation PhosphoSitePlus   Signor 21048939
T127 Phosphorylation Q5S007 (LRRK2) Signor 21048939
S139 Phosphorylation PhosphoSitePlus
S153 Phosphorylation PhosphoSitePlus
T164 Phosphorylation Signor 21048939
T164 Phosphorylation Q5S007 (LRRK2) Signor 21048939
S176 Phosphorylation PhosphoSitePlus
K242 Ubiquitination PhosphoSitePlus
S244 Phosphorylation PhosphoSitePlus
S249 Phosphorylation IEDB   PhosphoSitePlus   UniProt 27920218, 21406692, 33936100, ...27869121
K251 Ubiquitination PhosphoSitePlus
S252 Phosphorylation PhosphoSitePlus
T254 Phosphorylation PhosphoSitePlus
S257 Phosphorylation PhosphoSitePlus   UniProt 23186163
T264 Phosphorylation PhosphoSitePlus
C336 Methylation IEDB 31844290
K405 Ubiquitination PhosphoSitePlus
K418 Ubiquitination PhosphoSitePlus
Y427 Phosphorylation PhosphoSitePlus
K442 Ubiquitination PhosphoSitePlus
S518 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 25009260, 23186163, 18220336, ...19690332, 17392278
S518 Phosphorylation P05129 (PRKCG) PhosphoSitePlus   Signor 25009260
S518 Phosphorylation Q13153 (PAK1) neXtProt 17392278
T528 Phosphorylation PhosphoSitePlus
S539 Phosphorylation PhosphoSitePlus
C560 Phosphorylation UniProt 21406692, 24275569
K575 Ubiquitination PhosphoSitePlus
V579 Phosphorylation UniProt 21406692
T580 Phosphorylation PhosphoSitePlus
S581 Phosphorylation PhosphoSitePlus
S599 Phosphorylation PhosphoSitePlus
T603 Phosphorylation PhosphoSitePlus
T617 Phosphorylation PhosphoSitePlus
Y620 Phosphorylation PhosphoSitePlus
K645 Phosphorylation UniProt 21406692, 24275569
S653 Phosphorylation PhosphoSitePlus
S664 O-Glycosylation GlyGen 30444036, 25367160
S664 Phosphorylation UniProt 21406692
K675 Acetylation PhosphoSitePlus
S676 Phosphorylation PhosphoSitePlus
K678 Acetylation PhosphoSitePlus
K681 Acetylation PhosphoSitePlus
K682 Acetylation PhosphoSitePlus
S694 Phosphorylation IEDB   neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 15513924, ...35494241, 18184567, 18669648
S694 Phosphorylation Q14012 (CAMK1) neXtProt 18184567
S700 Phosphorylation PhosphoSitePlus
K702 Ubiquitination PhosphoSitePlus
S703 Phosphorylation PhosphoSitePlus
T704 Phosphorylation neXtProt   PhosphoSitePlus 15513924
K715 Ubiquitination PhosphoSitePlus
Y720 Phosphorylation PhosphoSitePlus
T722 Phosphorylation PhosphoSitePlus
S723 Phosphorylation PhosphoSitePlus
K725 Ubiquitination PhosphoSitePlus
S761 Phosphorylation PhosphoSitePlus   Signor 25009260
S761 Phosphorylation P05129 (PRKCG) PhosphoSitePlus   Signor 25009260
S763 Phosphorylation PhosphoSitePlus
S784 Phosphorylation PhosphoSitePlus
Y785 Phosphorylation PhosphoSitePlus
S800 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S71 Phosphorylation HPRD 17081983, 20068231
T76 Phosphorylation HPRD 18212344
S79 Phosphorylation HPRD 15144186
S215 Phosphorylation HPRD 20068231
T222 Phosphorylation HPRD 20068231
S340 Phosphorylation HPRD   PhosphoSitePlus 17081983, 19664994, 19651622, ...20068231, 18212344
Y442 Phosphorylation PhosphoSitePlus
S516 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 20166139, 18669648, 20068231, ...15513924
S525 Phosphorylation HPRD   PhosphoSitePlus 19651622, 15144186
T526 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 15144186, 15513924
T551 Phosphorylation PhosphoSitePlus
S554 Phosphorylation PhosphoSitePlus
K558 Ubiquitination PhosphoSitePlus
S560 Phosphorylation HPRD   PhosphoSitePlus 20166139
K571 Ubiquitination PhosphoSitePlus
T577 Phosphorylation PhosphoSitePlus
K578 Ubiquitination PhosphoSitePlus
S579 Phosphorylation HPRD   PhosphoSitePlus 17081983
K588 Ubiquitination PhosphoSitePlus
S589 Phosphorylation PhosphoSitePlus
Y595 Phosphorylation HPRD   PhosphoSitePlus 17389395
K598 Ubiquitination PhosphoSitePlus
S614 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S228 Phosphorylation HPRD 17081983, 20068231
T233 Phosphorylation HPRD 18212344
S236 Phosphorylation HPRD 15144186
S372 Phosphorylation HPRD 20068231
T379 Phosphorylation HPRD 20068231
S497 Phosphorylation HPRD 19651622, 19664994, 17081983, ...20068231, 18212344
S673 Phosphorylation HPRD 20166139, 18669648, 20068231
S682 Phosphorylation HPRD 19651622, 15144186
T683 Phosphorylation HPRD 15144186
S739 Phosphorylation HPRD 20068231
S740 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K251 N251 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S252 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
T264 M264 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
C336 F336 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S516 L516 Biomuta DOID:4159 / skin cancer [ cosmic ]
S525 R525 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S525 C525 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
T528 M528 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S554 * Biomuta DOID:4159 / skin cancer [ cosmic ]
V579 I579 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T580 M580 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S581 P581 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S589 I589 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
Y595 C595 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S664 L664 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
S673 L673 Biomuta DOID:4159 / skin cancer [ cosmic ]
K675 R675 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S676 I676 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
K678 E678 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S682 R682 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S682 C682 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S694 L694 Biomuta DOID:4159 / skin cancer [ cosmic ]
S703 C703 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S703 R703 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S800 F800 Biomuta DOID:4159 / skin cancer [ cosmic ]