Protein Information

Cytoscape View

UniProt AC / UniProt ID Q14152 / EIF3A_HUMAN
Protein Name Eukaryotic translation initiation factor 3 subunit A
Gene Name Name: EIF3A
Organism Homo sapiens (Human)

PRO ID PR:Q14152
DAG View
PRO Name eukaryotic translation initiation factor 3 subunit A (human)
Definition A eukaryotic translation initiation factor 3 subunit A that is encoded in the genome of human.
Short Label hEIF3A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q14152 (EIF3A) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
Y4 Phosphorylation PhosphoSitePlus
K13 Methylation PhosphoSitePlus
K13 Ubiquitination PhosphoSitePlus
K23 Ubiquitination PhosphoSitePlus
K24 Ubiquitination PhosphoSitePlus
Y32 Phosphorylation PhosphoSitePlus
K45 Ubiquitination PhosphoSitePlus
K68 Acetylation PhosphoSitePlus   UniProt 19608861
K68 Ubiquitination PhosphoSitePlus
Y72 Phosphorylation PhosphoSitePlus
K75 Ubiquitination PhosphoSitePlus
K84 Ubiquitination PhosphoSitePlus
K95 Ubiquitination PhosphoSitePlus
K105 Ubiquitination PhosphoSitePlus
T147 Phosphorylation PhosphoSitePlus
K196 Acetylation PhosphoSitePlus
K196 Ubiquitination PhosphoSitePlus
S261 Phosphorylation PhosphoSitePlus
K265 Ubiquitination PhosphoSitePlus
K268 Ubiquitination PhosphoSitePlus
K285 Ubiquitination PhosphoSitePlus
Y300 Phosphorylation PhosphoSitePlus
S303 Phosphorylation PhosphoSitePlus
K308 Ubiquitination PhosphoSitePlus
T311 Phosphorylation PhosphoSitePlus
T326 Phosphorylation PhosphoSitePlus
S328 Phosphorylation PhosphoSitePlus
T332 Phosphorylation PhosphoSitePlus
K351 Ubiquitination PhosphoSitePlus
Y382 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
K402 Ubiquitination PhosphoSitePlus
K409 Ubiquitination PhosphoSitePlus
K420 Ubiquitination PhosphoSitePlus
C478 S-Nitrosylation dbSNO 19483679
S492 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332
Y499 Phosphorylation PhosphoSitePlus
S528 Phosphorylation PhosphoSitePlus
K538 Ubiquitination PhosphoSitePlus
K559 Methylation PhosphoSitePlus
T574 Phosphorylation PhosphoSitePlus
S584 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
K591 Ubiquitination PhosphoSitePlus
K603 Ubiquitination PhosphoSitePlus
K617 Ubiquitination PhosphoSitePlus
K621 Ubiquitination PhosphoSitePlus
K632 Methylation PhosphoSitePlus
K632 Ubiquitination PhosphoSitePlus
K633 Methylation PhosphoSitePlus
K633 Ubiquitination PhosphoSitePlus
K634 Methylation PhosphoSitePlus
T635 Phosphorylation PhosphoSitePlus
T646 Phosphorylation PhosphoSitePlus
K651 Ubiquitination PhosphoSitePlus
K654 Ubiquitination PhosphoSitePlus
K672 Ubiquitination PhosphoSitePlus
K679 Ubiquitination PhosphoSitePlus
K682 Ubiquitination PhosphoSitePlus
K689 Ubiquitination PhosphoSitePlus
K693 Acetylation PhosphoSitePlus
K694 Acetylation PhosphoSitePlus
K694 Ubiquitination PhosphoSitePlus
R700 Methylation PhosphoSitePlus
K711 Ubiquitination PhosphoSitePlus
K720 Ubiquitination PhosphoSitePlus
R757 Methylation PhosphoSitePlus
K775 Ubiquitination PhosphoSitePlus
K777 Ubiquitination PhosphoSitePlus
R782 Methylation PhosphoSitePlus
K824 Ubiquitination PhosphoSitePlus
R842 Methylation PhosphoSitePlus
Y844 Phosphorylation PhosphoSitePlus
K850 Acetylation PhosphoSitePlus
S881 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17322308, 18220336
S882 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231, ...24275569
S884 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S888 Phosphorylation PhosphoSitePlus
S895 Phosphorylation PhosphoSitePlus   UniProt 23186163
T898 Phosphorylation PhosphoSitePlus
S949 Phosphorylation PhosphoSitePlus   UniProt 23186163
R956 Methylation PhosphoSitePlus
R960 Methylation PhosphoSitePlus
R966 Methylation PhosphoSitePlus
R976 Methylation PhosphoSitePlus
S978 Phosphorylation PhosphoSitePlus
R986 Methylation PhosphoSitePlus
S988 Phosphorylation PhosphoSitePlus
R1006 Methylation PhosphoSitePlus
R1026 Methylation PhosphoSitePlus
S1028 Phosphorylation PhosphoSitePlus   UniProt 23186163
R1040 Methylation PhosphoSitePlus
R1046 Methylation PhosphoSitePlus
R1057 Methylation PhosphoSitePlus
R1071 Methylation PhosphoSitePlus
R1081 Methylation PhosphoSitePlus
R1087 Methylation PhosphoSitePlus
R1091 Methylation PhosphoSitePlus
R1097 Methylation PhosphoSitePlus
R1101 Methylation PhosphoSitePlus
R1107 Methylation PhosphoSitePlus
R1111 Methylation PhosphoSitePlus
R1117 Methylation PhosphoSitePlus
R1127 Methylation PhosphoSitePlus
R1137 Methylation PhosphoSitePlus
S1149 Phosphorylation PhosphoSitePlus
R1156 Methylation PhosphoSitePlus
K1174 Acetylation PhosphoSitePlus
S1188 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18220336
S1198 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 24979134, 23186163, 17322308
R1238 Methylation PhosphoSitePlus
S1256 Phosphorylation PhosphoSitePlus
S1257 Phosphorylation PhosphoSitePlus
S1262 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1309 Phosphorylation PhosphoSitePlus
S1336 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 24979134, 18669648, 23186163, ...17322308
K1351 Acetylation PhosphoSitePlus
S1355 Phosphorylation PhosphoSitePlus
S1364 Phosphorylation PhosphoSitePlus   UniProt 17322308
T1368 Phosphorylation PhosphoSitePlus
T1372 Phosphorylation PhosphoSitePlus
T1378 Phosphorylation PhosphoSitePlus
T1379 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y382 Phosphorylation HPRD 18083107
S584 Phosphorylation HPRD 19651622, 18669648, 19664994, ...19664995, 20068231
S881 Phosphorylation HPRD 19651622, 20166139
S882 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 18212344
S884 Phosphorylation HPRD 20068231
S1336 Phosphorylation HPRD 18669648

Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:Q92900-2 (hUPF1/iso:2) Interaction PR:Q14152 (hEIF3A) PRO 18423202

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K68 N68 Biomuta DOID:363 / uterine cancer [ tcga ]
Y72 * Biomuta DOID:263 / kidney cancer [ cosmic ]
K84 N84 Biomuta DOID:363 / uterine cancer [ tcga ]
K308 R308 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
T332 I332 Biomuta DOID:1324 / lung cancer [ tcga ]
S528 L528 Biomuta DOID:1612 / breast cancer [ icgc ]
R700 T700 Biomuta DOID:1324 / lung cancer [ cosmic ]
K777 Q777 Biomuta DOID:4159 / skin cancer [ icgc ]
R842 Q842 Biomuta DOID:8618 / oral cavity cancer [ icgc ]
R956 Q956 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ] DOID:3070 / malignant glioma [ tcga ]
R956 W956 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:4362 / cervical cancer [ tcga ]
R960 C960 Biomuta DOID:1909 / melanoma [ cosmic ]
R960 H960 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
R976 G976 Biomuta DOID:1909 / melanoma [ tcga ]
S988 P988 Biomuta DOID:2531 / hematologic cancer [ tcga ]
R1040 H1040 Biomuta DOID:3070 / malignant glioma [ tcga ]
R1057 * Biomuta DOID:363 / uterine cancer [ tcga ]
R1071 * Biomuta DOID:363 / uterine cancer [ tcga ]
R1087 W1087 Biomuta DOID:1909 / melanoma [ cosmic ]
R1097 W1097 Biomuta DOID:5041 / esophageal cancer [ icgc ]
R1107 Q1107 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ] DOID:263 / kidney cancer [ tcga ]
R1107 W1107 Biomuta DOID:1909 / melanoma [ cosmic ]
R1111 * Biomuta DOID:2531 / hematologic cancer [ tcga ]
R1117 Q1117 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
R1127 I1127 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
R1156 W1156 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S1198 L1198 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
R1238 S1238 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
R1238 H1238 Biomuta DOID:10534 / stomach cancer [ tcga ]
R1238 C1238 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S1256 C1256 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S1257 L1257 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S1309 Y1309 Biomuta DOID:5041 / esophageal cancer [ tcga ]