Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14145 / KEAP1_HUMAN
Protein Name Kelch-like ECH-associated protein 1
Gene Name Name: KEAP1
Synonyms:INRF2;
Organism Homo sapiens (Human)

PRO ID PR:Q14145
DAG View
PRO Name kelch-like ECH-associated protein 1 (human)
Definition A kelch-like ECH-associated protein 1 that is encoded in the genome of human.
Short Label hKEAP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14145 (KEAP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Ubiquitination PRO
Y33 Phosphorylation PhosphoSitePlus
K39 Ubiquitination PhosphoSitePlus
T43 Phosphorylation PhosphoSitePlus
T51 Phosphorylation RLIMS-P 30765703
S53 Phosphorylation PhosphoSitePlus   RLIMS-P 30765703
Y54 Phosphorylation PhosphoSitePlus
T55 Phosphorylation PhosphoSitePlus   RLIMS-P 30765703
T60 Phosphorylation PhosphoSitePlus
K61 Ubiquitination PhosphoSitePlus
T80 Phosphorylation RLIMS-P 30765703
K84 Ubiquitination PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
K108 Ubiquitination PhosphoSitePlus
T112 Phosphorylation PhosphoSitePlus
K131 Acetylation PhosphoSitePlus
Y141 Phosphorylation RLIMS-P 18434303, 26773127
C273 S-Nitrosylation dbSNO 23796488, 14585973
T277 Phosphorylation PhosphoSitePlus
K287 Ubiquitination PhosphoSitePlus
C288 S-Nitrosylation dbSNO 23796488, 14585973
S293 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P 18691976, 30576774
S295 Phosphorylation HPRD   PhosphoSitePlus 18691976
K298 Ubiquitination PhosphoSitePlus
K312 Ubiquitination PhosphoSitePlus
S599 Phosphorylation Q02156 (PRKCE) PhosphoSitePlus   RLIMS-P 24127568
S602 Phosphorylation Q02156 (PRKCE) PhosphoSitePlus   RLIMS-P 24127568
K615 Ubiquitination PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048099 (hKEAP1/UbiqLys+) ub PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q13501 (SQSTM1) S349 Q14145 (KEAP1) unknown eFIP 29930914
Phosphorylation Q13501 (SQSTM1) S349 Q14145 (KEAP1) unknown eFIP 30533198
Phosphorylation Q16236 (NFE2L2) S40 Q14145 (KEAP1) unknown eFIP 28604588
Phosphorylation Q16236 (NFE2L2) S40 Q14145 (KEAP1) unknown eFIP 12700136
Phosphorylation Q16236 (NFE2L2) S40 Q14145 (KEAP1) unknown eFIP 22558124
Phosphorylation Q5JTC6 (AMER1) S286 Q14145 (KEAP1) unknown eFIP 22215675


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T43 M43 Biomuta DOID:363 / uterine cancer [ cosmic ]
S53 I53 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
Y54 C54 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y54 D54 Biomuta DOID:263 / kidney cancer [ cosmic ]
T80 I80 Biomuta DOID:9256 / colorectal cancer [ tcga ]
K84 N84 Biomuta DOID:10534 / stomach cancer [ tcga ]
K97 N97 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
K97 * Biomuta DOID:3571 / liver cancer [ tcga ]
Y141 C141 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y141 F141 Biomuta DOID:1324 / lung cancer [ cosmic ]
T277 M277 Biomuta DOID:8618 / oral cavity cancer [ icgc ]
K287 * Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
C288 R288 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
C288 Y288 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K615 * Biomuta DOID:1324 / lung cancer [ cosmic ]