iPTMnet Report for Q14145 (KEAP1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14145 / KEAP1_HUMAN
Protein Name Kelch-like ECH-associated protein 1
Gene Name Name: KEAP1
Synonyms:INRF2;
Organism Homo sapiens (Human)

PRO ID PR:Q14145
DAG View
PRO Name kelch-like ECH-associated protein 1 (human)
Definition A kelch-like ECH-associated protein 1 that is encoded in the genome of human.
Short Label hKEAP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14145 (KEAP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Ubiquitination PRO
Y33 Phosphorylation PhosphoSitePlus
K39 Ubiquitination PhosphoSitePlus
T43 Phosphorylation PhosphoSitePlus
T51 Phosphorylation RLIMS-P 30765703
S53 Phosphorylation PhosphoSitePlus   RLIMS-P 30765703
Y54 Phosphorylation PhosphoSitePlus
T55 Phosphorylation PhosphoSitePlus   RLIMS-P 30765703
T60 Phosphorylation PhosphoSitePlus
K61 Ubiquitination PhosphoSitePlus
T80 Phosphorylation RLIMS-P 30765703
K84 Ubiquitination PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
S102 O-Glycosylation GlyGen   PhosphoSitePlus 23301498, 28663241
S103 O-Glycosylation GlyGen   PhosphoSitePlus 23301498, 28663241
S104 O-Glycosylation GlyGen   PhosphoSitePlus 23301498, 28663241
S104 Phosphorylation PhosphoSitePlus
K108 Ubiquitination PhosphoSitePlus
T112 Phosphorylation PhosphoSitePlus
K131 Acetylation PhosphoSitePlus
Y141 Phosphorylation RLIMS-P 18434303, 28159763, 26773127
S166 O-Glycosylation GlyGen   PhosphoSitePlus 23301498, 28663241
C196 Methylation IEDB 31844290
C226 Methylation IEDB 31844290
C241 Methylation IEDB 31844290
C273 Methylation IEDB 31844290
C273 S-Nitrosylation dbSNO 23796488, 14585973
T277 Phosphorylation PhosphoSitePlus
K287 Ubiquitination PhosphoSitePlus
C288 S-Nitrosylation dbSNO 23796488, 14585973
S293 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P 18691976, 30576774
S295 Phosphorylation HPRD   PhosphoSitePlus 18691976
K298 Ubiquitination PhosphoSitePlus
K312 Acetylation PhosphoSitePlus
K312 Ubiquitination PhosphoSitePlus
K323 Ubiquitination PhosphoSitePlus
T388 O-Glycosylation GlyGen   PhosphoSitePlus 23301498, 28663241
S390 O-Glycosylation GlyGen   PhosphoSitePlus 23301498, 28663241
S391 O-Glycosylation GlyGen   PhosphoSitePlus 23301498, 28663241
C395 Methylation IEDB 31844290
T400 O-Glycosylation GlyGen   PhosphoSitePlus 23301498, 28663241
S404 O-Glycosylation GlyGen   PhosphoSitePlus 23301498, 28663241
S410 O-Glycosylation GlyGen   PhosphoSitePlus 23301498, 28663241
S533 O-Glycosylation GlyGen 23301498, 28663241
S599 Phosphorylation Q02156 (PRKCE) PhosphoSitePlus   RLIMS-P 24127568
S602 Phosphorylation Q02156 (PRKCE) PhosphoSitePlus   RLIMS-P 24127568
K615 Ubiquitination PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048099 (hKEAP1/UbiqLys+) ub PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q13501 (SQSTM1) S349 Q14145 (KEAP1) increased_association eFIP 33854041
Phosphorylation Q16236 (NFE2L2) S40 Q14145 (KEAP1) unknown eFIP 28604588
Phosphorylation Q16236 (NFE2L2) S40 Q14145 (KEAP1) unknown eFIP 22558124
Phosphorylation Q16236 (NFE2L2) S40 Q14145 (KEAP1) unknown eFIP 12700136
Phosphorylation Q5JTC6 (AMER1) S286 Q14145 (KEAP1) unknown eFIP 22215675
Phosphorylation Q60795 (Nfe2l2) S40 Q14145 (KEAP1) increased_association eFIP 32938017


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y33 H33 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
Y33 C33 Biomuta DOID:363 / uterine cancer [ cosmic ]
T43 M43 Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:5158 / pleural cancer [ cosmic ]
T51 S51 Biomuta [ cosmic ]
S53 I53 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
Y54 C54 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y54 D54 Biomuta DOID:263 / kidney cancer [ cosmic ]
T80 I80 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K84 N84 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K97 * Biomuta DOID:3571 / liver cancer [ cosmic, tcga ] DOID:1324 / lung cancer [ cosmic ]
K97 N97 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S102 L102 Biomuta DOID:4606 / bile duct cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
S103 F103 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S103 Y103 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:11934 / head and neck cancer [ icgc ]
S104 R104 Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic, icgc ]
T112 S112 Biomuta DOID:1324 / lung cancer [ cosmic ]
K131 * Biomuta DOID:1324 / lung cancer [ cosmic ]
Y141 C141 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y141 F141 Biomuta DOID:1324 / lung cancer [ cosmic ]
C196 F196 Biomuta DOID:1324 / lung cancer [ cosmic ]
C241 R241 Biomuta DOID:3571 / liver cancer [ cosmic ]
C241 Y241 Biomuta DOID:3571 / liver cancer [ cosmic ]
C273 S273 Biomuta DOID:1324 / lung cancer [ cosmic ]
T277 M277 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
K287 * Biomuta DOID:1324 / lung cancer [ cosmic ]
C288 R288 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
C288 Y288 Biomuta DOID:10534 / stomach cancer [ cosmic ]
C288 F288 Biomuta DOID:1324 / lung cancer [ cosmic ]
S293 A293 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S295 A295 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S295 P295 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K615 * Biomuta DOID:1324 / lung cancer [ cosmic ]