iPTMnet Report for Q14123 (PDE1C)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14123 / PDE1C_HUMAN
Protein Name Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C
Gene Name Name: PDE1C
Organism Homo sapiens (Human)

PRO ID PR:Q14123
DAG View
PRO Name dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (human)
Definition A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C that is encoded in the genome of human.
Short Label hPDE1C
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14123 (PDE1C) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19369195
S3 Phosphorylation PhosphoSitePlus
T5 Phosphorylation PhosphoSitePlus
Y18 Phosphorylation PhosphoSitePlus
S46 Phosphorylation PhosphoSitePlus
T194 Phosphorylation PhosphoSitePlus
Y196 Phosphorylation PhosphoSitePlus
S413 Phosphorylation PhosphoSitePlus
T438 Phosphorylation PhosphoSitePlus
S468 Phosphorylation PhosphoSitePlus
S469 Phosphorylation PhosphoSitePlus
S472 Phosphorylation PhosphoSitePlus
Y503 Phosphorylation PhosphoSitePlus
S505 Phosphorylation PhosphoSitePlus
K695 Methylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S3 L3 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T5 A5 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
Y196 S196 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S468 W468 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S468 L468 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S469 N469 Biomuta DOID:4159 / skin cancer [ cosmic ]
S472 N472 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S505 R505 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]