iPTMnet Report for Q14114 (LRP8)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14114 / LRP8_HUMAN
Protein Name Low-density lipoprotein receptor-related protein 8 precursor
Gene Name Name: LRP8
Synonyms:APOER2;
Organism Homo sapiens (Human)

PRO ID PR:Q14114
DAG View
PRO Name low-density lipoprotein receptor-related protein 8 (human)
Definition A low-density lipoprotein receptor-related protein 8 that is encoded in the genome of human.
Short Label hLRP8
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14114 (LRP8) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO
T85 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
S118 Phosphorylation PhosphoSitePlus
T123 Phosphorylation PhosphoSitePlus
S238 Phosphorylation PhosphoSitePlus
T514 O-Glycosylation GlyGen 35289036, 36240223
S516 O-Glycosylation GlyGen 35289036, 36240223
N518 N-Glycosylation GlyGen 24190977
T763 O-Glycosylation GlyGen 35289036, 36240223
T764 O-Glycosylation GlyGen 35289036, 36240223
Y866 Phosphorylation PhosphoSitePlus
K868 Ubiquitination PhosphoSitePlus
T870 Phosphorylation PhosphoSitePlus
K921 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y686 Phosphorylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048253 (hLRP8/SigPep-/PhosTyr+) p PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T85 I85 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S118 F118 Biomuta DOID:4159 / skin cancer [ cosmic ]
T514 N514 Biomuta DOID:3571 / liver cancer [ cosmic ]
T764 I764 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y866 N866 Biomuta DOID:5041 / esophageal cancer [ cosmic ]