iPTMnet Report for Q14103 (HNRNPD)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14103 / HNRPD_HUMAN
Protein Name Heterogeneous nuclear ribonucleoprotein D0
Gene Name Name: HNRNPD
Synonyms:AUF1,HNRPD;
Organism Homo sapiens (Human)

PRO ID PR:Q14103
DAG View
PRO Name heterogeneous nuclear ribonucleoprotein D0 (human)
Definition A heterogeneous nuclear ribonucleoprotein D0 that is encoded in the genome of human.
Short Label hHNRNPD
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14103 (HNRNPD) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330
S2 Phosphorylation PhosphoSitePlus
S71 Phosphorylation PhosphoSitePlus   UniProt 20068231
K72 Acetylation PhosphoSitePlus
K72 Ubiquitination PhosphoSitePlus
S80 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17287340, 18669648, ...23186163, 20068231
S82 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15659558, 17081983, 18669648, ...17287340, 19690332
S83 Phosphorylation P49841 (GSK3B) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21406692, 17287340, 17081983, ...11903055, 18669648, 12819194, 12819195, 23186163, 20068231
S87 Phosphorylation P17612 (PRKACA) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 12819195, 17287340, 11903055, ...12819194
T91 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17287340, 23186163
R94 Methylation PhosphoSitePlus
K98 Acetylation PhosphoSitePlus
S105 Phosphorylation PhosphoSitePlus
K110 Acetylation PhosphoSitePlus
K110 Ubiquitination PhosphoSitePlus
K111 Acetylation PhosphoSitePlus
K111 Ubiquitination PhosphoSitePlus
K114 Acetylation PhosphoSitePlus
K114 Ubiquitination PhosphoSitePlus
K119 Acetylation PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
C126 S-Nitrosylation dbSNO 19483679
T127 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 24275569
K129 Acetylation PhosphoSitePlus
K129 Ubiquitination PhosphoSitePlus
T134 Phosphorylation PhosphoSitePlus
S137 Phosphorylation PhosphoSitePlus
R138 Methylation PhosphoSitePlus
K146 Methylation PhosphoSitePlus
K153 Acetylation PhosphoSitePlus
K153 Ubiquitination PhosphoSitePlus
K158 Acetylation PhosphoSitePlus
K161 Acetylation PhosphoSitePlus
K165 Acetylation PhosphoSitePlus   UniProt 19608861
K165 Ubiquitination PhosphoSitePlus
K183 Ubiquitination PhosphoSitePlus
S190 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 24275569, 19690332, 20068231
T193 Phosphorylation P24941 (CDK2) phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 18847512, ...15302935, 18669648, 19690332, 20068231
K197 Acetylation PhosphoSitePlus
K197 Sumoylation PhosphoSitePlus
K197 Ubiquitination PhosphoSitePlus
Y201 Phosphorylation PhosphoSitePlus
S210 Phosphorylation PhosphoSitePlus
K218 Acetylation PhosphoSitePlus
K218 Methylation PhosphoSitePlus
K218 Ubiquitination PhosphoSitePlus
C226 S-Nitrosylation dbSNO 19483679
K231 Acetylation PhosphoSitePlus
K231 Ubiquitination PhosphoSitePlus
K238 Acetylation PhosphoSitePlus
K243 Acetylation PhosphoSitePlus
K243 Ubiquitination PhosphoSitePlus
Y244 Phosphorylation PhosphoSitePlus
K251 Acetylation PhosphoSitePlus   UniProt 19608861
K251 Ubiquitination PhosphoSitePlus
C252 Methylation IEDB 31844290
K255 Ubiquitination PhosphoSitePlus
K260 Methylation PhosphoSitePlus
K260 Ubiquitination PhosphoSitePlus
Y263 Methylation UniProt 24129315
Y263 Phosphorylation PhosphoSitePlus
S271 Phosphorylation PhosphoSitePlus   UniProt 23186163
R272 Methylation PhosphoSitePlus   UniProt 24129315
G273 Acetylation UniProt 19608861
R278 Methylation PhosphoSitePlus   UniProt 24129315
R280 Methylation PhosphoSitePlus   UniProt 24129315
R282 Methylation PhosphoSitePlus   UniProt 24129315
Q292 Acetylation UniProt 19608861
Y329 Phosphorylation PhosphoSitePlus
Y332 Phosphorylation PhosphoSitePlus
R345 Methylation PhosphoSitePlus   UniProt 24129315, 15782174
S351 Phosphorylation PhosphoSitePlus
Y352 Phosphorylation PhosphoSitePlus
K353 Acetylation PhosphoSitePlus
K353 Methylation PhosphoSitePlus
Y355 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S71 Phosphorylation HPRD 17081983, 20068231, 18452278
S80 Phosphorylation HPRD 18691976, 17287340, 17081983, ...19664995, 18452278, 19651622, 18669648, 20166139, 19415658, 20068231
S82 Phosphorylation HPRD 17287340, 19664995, 18452278, ...19651622, 18669648, 20166139, 15659558, 19415658, 20068231
S83 Phosphorylation P49841 (GSK3B) HPRD 19413330, 18691976, 17287340, ...18212344, 11903055, 18452278, 19651622, 12819195, 18669648, 20166139, 19415658, 20068231, 20068230
S87 Phosphorylation P17612 (PRKACA) HPRD 12819195, 19651622, 17287340, ...11903055
T91 Phosphorylation HPRD 17287340, 20068231
T127 Phosphorylation HPRD 18669648, 19664994
S190 Phosphorylation HPRD 19413330, 17081983, 19664994, ...19651622, 18669648, 19415658, 20068231
T193 Phosphorylation HPRD 19413330, 18691976, 19664995, ...19651622, 18669648, 19415658, 20068231
Site PTM Type PTM Enzyme Score Source PMID
T108 Phosphorylation HPRD 18669648, 19664994
S171 Phosphorylation HPRD 19413330, 17081983, 19664994, ...19651622, 18669648, 19415658, 20068231
T174 Phosphorylation HPRD 19413330, 18691976, 19664995, ...19651622, 18669648, 19415658, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S71 Phosphorylation HPRD 17081983, 20068231, 18452278
S80 Phosphorylation HPRD 18691976, 17287340, 17081983, ...19664995, 18452278, 19651622, 18669648, 20166139, 19415658, 20068231
S82 Phosphorylation HPRD 17287340, 19664995, 18452278, ...19651622, 18669648, 20166139, 15659558, 19415658, 20068231
S83 Phosphorylation P49841 (GSK3B) HPRD   PhosphoSitePlus 19413330, 17287340, 18212344, ...18691976, 11903055, 18452278, 19651622, 12819195, 18669648, 20166139, 19415658, 20068231, 20068230
S87 Phosphorylation P17612 (PRKACA) HPRD   PhosphoSitePlus 12819195, 17287340, 11903055, ...19651622
T91 Phosphorylation HPRD 17287340, 20068231
T127 Phosphorylation HPRD 18669648, 19664994
K158 Acetylation PhosphoSitePlus
S190 Phosphorylation HPRD 19413330, 17081983, 19664994, ...19651622, 18669648, 19415658, 20068231
T193 Phosphorylation HPRD   PhosphoSitePlus 19413330, 18691976, 19664995, ...19651622, 18669648, 19415658, 20068231
R272 Methylation PhosphoSitePlus
R278 Methylation PhosphoSitePlus
R280 Methylation PhosphoSitePlus
R282 Methylation PhosphoSitePlus
S288 Phosphorylation PhosphoSitePlus
Y290 Phosphorylation PhosphoSitePlus
K292 Acetylation PhosphoSitePlus
K292 Ubiquitination PhosphoSitePlus
S294 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T108 Phosphorylation HPRD 18669648, 19664994
S171 Phosphorylation HPRD 19413330, 17081983, 19664994, ...19651622, 18669648, 19415658, 20068231
T174 Phosphorylation HPRD 19413330, 18691976, 19664995, ...19651622, 18669648, 19415658, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K72 N72 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K72 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S87 F87 Biomuta DOID:4159 / skin cancer [ cosmic ]
T108 I108 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc, cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc, cosmic, icgc ]
K110 E110 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
K119 R119 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T127 I127 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S137 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic, tcga ]
R138 S138 Biomuta DOID:363 / uterine cancer [ icgc ]
K153 R153 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K183 N183 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
K238 T238 Biomuta DOID:363 / uterine cancer [ icgc ]
Y263 C263 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R272 K272 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R280 H280 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R280 C280 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K292 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
Y329 H329 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y332 C332 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S351 N351 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]