iPTMnet Report for Q14004 (CDK13)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14004 / CDK13_HUMAN
Protein Name Cyclin-dependent kinase 13
Gene Name Name: CDK13
Synonyms:CDC2L,CDC2L5,CHED,KIAA1791;
Organism Homo sapiens (Human)

PRO ID PR:Q14004
DAG View
PRO Name cyclin-dependent kinase 13 (human)
Definition A cyclin-dependent kinase 13 that is encoded in the genome of human.
Short Label hCDK13
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14004 (CDK13) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S3 Phosphorylation PhosphoSitePlus
S4 Phosphorylation PhosphoSitePlus
S5 Phosphorylation PhosphoSitePlus
S135 Phosphorylation PhosphoSitePlus
S136 Phosphorylation PhosphoSitePlus
T141 Phosphorylation PhosphoSitePlus
S151 Phosphorylation PhosphoSitePlus
S204 Phosphorylation PhosphoSitePlus
S205 Phosphorylation PhosphoSitePlus
S209 Phosphorylation PhosphoSitePlus
S236 Phosphorylation PhosphoSitePlus
S238 Phosphorylation PhosphoSitePlus
S260 Phosphorylation PhosphoSitePlus
S262 Phosphorylation PhosphoSitePlus
S268 Phosphorylation PhosphoSitePlus
S276 Phosphorylation PhosphoSitePlus
S281 Phosphorylation PhosphoSitePlus
S285 Phosphorylation PhosphoSitePlus
S291 Phosphorylation PhosphoSitePlus
S315 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 23186163, ...17081983
S317 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...15302935, 18669648
S325 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17081983
S328 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S337 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S340 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 15302935
S342 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 15302935
S348 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S349 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y351 Phosphorylation PhosphoSitePlus
S352 Phosphorylation PhosphoSitePlus
S358 Phosphorylation PhosphoSitePlus   UniProt 23186163
S360 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y362 Phosphorylation PhosphoSitePlus
S363 Phosphorylation PhosphoSitePlus
S367 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935, 17081983
S369 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S371 Phosphorylation PhosphoSitePlus
S374 Phosphorylation PhosphoSitePlus
S375 Phosphorylation PhosphoSitePlus
Y376 Phosphorylation PhosphoSitePlus
S383 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 15302935, ...18669648, 20068231
S385 Phosphorylation PhosphoSitePlus
S391 Phosphorylation PhosphoSitePlus
S395 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 17081983
S397 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 17081983
Y399 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S400 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692
S409 Phosphorylation PhosphoSitePlus
S411 Phosphorylation PhosphoSitePlus
S413 Phosphorylation PhosphoSitePlus
Y415 Phosphorylation PhosphoSitePlus
S431 Phosphorylation PhosphoSitePlus
S433 Phosphorylation PhosphoSitePlus
S436 Phosphorylation PhosphoSitePlus
S437 Phosphorylation O14757 (CHEK1) phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 16964243, ...15144186, 18669648, 21851590, 20068231, 17081983
S439 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 20068231
S441 Phosphorylation phospho.ELM   PhosphoSitePlus 16964243
T442 Phosphorylation IEDB   phospho.ELM   PhosphoSitePlus 32387766, 15144186
S490 O-Glycosylation GlyGen 33214551, 28314751, 30379171, ...32574038, 34019948, 35254053, 35132862, 31492838, 29351928, 35289036, 30620550, 29237092, 30059200
S490 Phosphorylation PhosphoSitePlus
S493 Phosphorylation PhosphoSitePlus
T494 Phosphorylation PhosphoSitePlus
T496 Phosphorylation PhosphoSitePlus
T500 Phosphorylation PhosphoSitePlus
T502 Phosphorylation PhosphoSitePlus
S507 Phosphorylation PhosphoSitePlus
K519 Sumoylation PhosphoSitePlus
S525 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 20068231
S527 Phosphorylation PhosphoSitePlus
S528 Phosphorylation PhosphoSitePlus
T531 Phosphorylation PhosphoSitePlus
T539 Phosphorylation PhosphoSitePlus
K556 Acetylation PhosphoSitePlus   UniProt 19608861
K566 Acetylation PhosphoSitePlus
K583 Acetylation PhosphoSitePlus
K585 Acetylation PhosphoSitePlus
T588 Phosphorylation PhosphoSitePlus   UniProt 23186163
S590 Phosphorylation PhosphoSitePlus
S624 Phosphorylation PhosphoSitePlus
S630 Phosphorylation PhosphoSitePlus
K632 Ubiquitination PhosphoSitePlus
S662 Phosphorylation phospho.ELM 18669648
S664 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y687 Phosphorylation PhosphoSitePlus
K699 Ubiquitination PhosphoSitePlus
Y716 Phosphorylation PhosphoSitePlus
K742 Ubiquitination PhosphoSitePlus
T748 Phosphorylation PhosphoSitePlus
K774 Ubiquitination PhosphoSitePlus
K781 Ubiquitination PhosphoSitePlus
Y827 Phosphorylation PhosphoSitePlus
S864 Phosphorylation PhosphoSitePlus
S867 Phosphorylation PhosphoSitePlus
T871 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...20068231
K951 Acetylation PhosphoSitePlus
S1022 Phosphorylation PhosphoSitePlus
T1034 Phosphorylation PhosphoSitePlus
K1045 Ubiquitination PhosphoSitePlus
S1048 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19369195, 18669648, 23186163
S1054 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 18220336
T1056 Phosphorylation PhosphoSitePlus
T1058 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17081983
S1065 Phosphorylation PhosphoSitePlus
S1066 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
T1143 Phosphorylation phospho.ELM 18669648
S1146 Phosphorylation PhosphoSitePlus
T1147 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1153 Phosphorylation PhosphoSitePlus
S1163 Phosphorylation PhosphoSitePlus
T1165 Phosphorylation PhosphoSitePlus
K1199 Ubiquitination PhosphoSitePlus
S1225 Phosphorylation PhosphoSitePlus
T1226 Phosphorylation PhosphoSitePlus
S1229 Phosphorylation PhosphoSitePlus
T1246 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...17081983, 18220336, 18669648
Y1277 Phosphorylation PhosphoSitePlus
T1279 O-Glycosylation GlyGen 34846842, 33214551, 28314751, ...30379171, 32574038, 34019948, 35254053, 35132862, 31492838, 29351928, 35289036, 30620550, 29237092, 30059200
T1286 O-Glycosylation GlyGen 33214551, 28314751, 30379171, ...32574038, 34019948, 35254053, 35132862, 31492838, 29351928, 35289036, 30620550, 29237092, 30059200
T1287 O-Glycosylation GlyGen   IEDB 33214551, 28314751, 35254053, ...30379171, 32574038, 32938750, 34019948, 30059200, 35132862, 31492838, 29351928, 35289036, 30620550, 29237092
S1288 O-Glycosylation GlyGen 33214551, 28314751, 30379171, ...32574038, 34019948, 35254053, 35132862, 31492838, 29351928, 35289036, 30620550, 29237092, 30059200
S1289 O-Glycosylation GlyGen 33214551, 28314751, 30379171, ...32574038, 34019948, 35254053, 35132862, 31492838, 29351928, 35289036, 30620550, 29237092, 30059200
S1290 O-Glycosylation GlyGen 34846842, 33214551, 28314751, ...30379171, 32574038, 34019948, 35254053, 35132862, 31492838, 29351928, 35289036, 30620550, 29237092, 30059200
T1292 O-Glycosylation GlyGen 33214551, 28314751, 30379171, ...32574038, 34019948, 35254053, 35132862, 31492838, 29351928, 35289036, 30620550, 29237092, 30059200
K1316 Ubiquitination PhosphoSitePlus
S1331 O-Glycosylation GlyGen 33214551, 28314751, 30379171, ...32574038, 34019948, 35254053, 35132862, 31492838, 29351928, 35289036, 30620550, 29237092, 30059200
S1342 Phosphorylation PhosphoSitePlus
S1346 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S315 Phosphorylation HPRD 19651622, 18691976, 18669648, ...17081983, 20068231
S317 Phosphorylation HPRD 18691976, 18767875, 15302935, ...19651622, 18669648, 20068231
S325 Phosphorylation HPRD 18691976, 17081983, 18767875, ...19651622, 18669648, 20068231
S328 Phosphorylation HPRD 19651622, 18669648, 20068231
S337 Phosphorylation HPRD 18669648
S340 Phosphorylation HPRD 19651622, 18691976, 18669648, ...15302935, 20068231
S342 Phosphorylation HPRD 19651622, 18691976, 18669648, ...15302935, 20068231
S348 Phosphorylation HPRD 19651622, 18691976, 18669648, ...20068231
S349 Phosphorylation HPRD 18691976, 18669648, 20068231
Y351 Phosphorylation HPRD 20068231
S358 Phosphorylation HPRD 18691976
S360 Phosphorylation HPRD 18691976
S367 Phosphorylation HPRD 15302935
S383 Phosphorylation HPRD 19413330, 18691976, 18767875, ...19664994, 19664995, 19651622, 17322306, 18669648, 20068231
S395 Phosphorylation HPRD 19651622, 18691976, 18669648, ...17081983
S397 Phosphorylation HPRD 19651622, 18691976, 18669648, ...17081983
Y399 Phosphorylation HPRD 18669648, 17081983
S400 Phosphorylation HPRD 19651622, 18691976, 18669648, ...17081983
S431 Phosphorylation HPRD 17081983
S437 Phosphorylation HPRD 18691976, 16964243, 19664994, ...15144186, 19651622, 18669648, 20068231
S439 Phosphorylation HPRD 18691976, 16964243, 19651622, ...17322306, 18669648, 20068231
S441 Phosphorylation HPRD 15144186, 19664994, 16964243, ...20068231
T442 Phosphorylation HPRD 17081983, 20068231
T444 Phosphorylation HPRD 17081983
S490 Phosphorylation HPRD 20068231
S493 Phosphorylation HPRD 18491316
T494 Phosphorylation HPRD 19413330
S525 Phosphorylation HPRD 18691976, 17081983, 20068231
S527 Phosphorylation HPRD 17081983
S624 Phosphorylation HPRD 20068231
S662 Phosphorylation HPRD 18669648
S664 Phosphorylation HPRD 18691976, 18669648
Y870 Phosphorylation HPRD 19651622, 18691976, 20068231
T871 Phosphorylation HPRD 19651622, 18691976, 18669648, ...20068231, 18452278
S1048 Phosphorylation HPRD 18669648
S1054 Phosphorylation HPRD 18669648, 17081983
T1056 Phosphorylation HPRD 18691976, 17081983, 19664995
T1058 Phosphorylation HPRD 18669648, 19664995
S1066 Phosphorylation HPRD 17525332
T1143 Phosphorylation HPRD 18669648
S1146 Phosphorylation HPRD 18691976, 18491316
T1147 Phosphorylation HPRD 18691976, 18669648
T1246 Phosphorylation HPRD 18691976, 17081983, 19664995, ...18452278, 18669648, 18707149, 20068231
Y1277 Phosphorylation HPRD 20068231
S1471 Phosphorylation HPRD 18691976
Site PTM Type PTM Enzyme Score Source PMID
S204 Phosphorylation PhosphoSitePlus
S205 Phosphorylation PhosphoSitePlus
S281 Phosphorylation PhosphoSitePlus
S285 Phosphorylation PhosphoSitePlus
S315 Phosphorylation HPRD 19651622, 18691976, 18669648, ...17081983, 20068231
S317 Phosphorylation HPRD 18691976, 18767875, 15302935, ...19651622, 18669648, 20068231
S325 Phosphorylation HPRD 18691976, 17081983, 18767875, ...19651622, 18669648, 20068231
S328 Phosphorylation HPRD 19651622, 18669648, 20068231
S337 Phosphorylation HPRD   PhosphoSitePlus 18669648
S340 Phosphorylation HPRD   PhosphoSitePlus 18691976, 15302935, 19651622, ...18669648, 20068231
S342 Phosphorylation HPRD 19651622, 18691976, 18669648, ...15302935, 20068231
S348 Phosphorylation HPRD 19651622, 18691976, 18669648, ...20068231
S349 Phosphorylation HPRD   PhosphoSitePlus 18691976, 18669648, 20068231
Y351 Phosphorylation HPRD 20068231
S358 Phosphorylation HPRD   PhosphoSitePlus 18691976
S360 Phosphorylation HPRD   PhosphoSitePlus 18691976
S367 Phosphorylation HPRD 15302935
S383 Phosphorylation HPRD 19413330, 18691976, 18767875, ...19664994, 19664995, 19651622, 17322306, 18669648, 20068231
S395 Phosphorylation HPRD 19651622, 18691976, 18669648, ...17081983
S397 Phosphorylation HPRD 19651622, 18691976, 18669648, ...17081983
Y399 Phosphorylation HPRD 18669648, 17081983
S400 Phosphorylation HPRD 19651622, 18691976, 18669648, ...17081983
S431 Phosphorylation HPRD 17081983
S437 Phosphorylation HPRD 18691976, 16964243, 19664994, ...15144186, 19651622, 18669648, 20068231
S439 Phosphorylation HPRD 18691976, 16964243, 19651622, ...17322306, 18669648, 20068231
S441 Phosphorylation HPRD 15144186, 19664994, 16964243, ...20068231
T442 Phosphorylation HPRD 17081983, 20068231
T444 Phosphorylation HPRD 17081983
S490 Phosphorylation HPRD 20068231
S493 Phosphorylation HPRD 18491316
T494 Phosphorylation HPRD   PhosphoSitePlus 19413330
S525 Phosphorylation HPRD 18691976, 17081983, 20068231
S527 Phosphorylation HPRD 17081983
S624 Phosphorylation HPRD 20068231
S662 Phosphorylation HPRD 18669648
S664 Phosphorylation HPRD 18691976, 18669648
Y870 Phosphorylation HPRD 19651622, 18691976, 20068231
T871 Phosphorylation HPRD 19651622, 18691976, 18669648, ...20068231, 18452278
S1048 Phosphorylation HPRD 18669648
S1054 Phosphorylation HPRD   phospho.ELM 18669648, 17081983, 18220336
T1056 Phosphorylation HPRD 18691976, 17081983, 19664995
T1058 Phosphorylation HPRD 18669648, 19664995
S1066 Phosphorylation HPRD 17525332
S1070 Phosphorylation PhosphoSitePlus
T1083 Phosphorylation HPRD 18669648
S1086 Phosphorylation HPRD   PhosphoSitePlus 18691976, 18491316
T1087 Phosphorylation HPRD   PhosphoSitePlus 18691976, 18669648
S1092 Phosphorylation PhosphoSitePlus
T1186 Phosphorylation HPRD 18691976, 17081983, 19664995, ...18452278, 18669648, 18707149, 20068231
Y1217 Phosphorylation HPRD 20068231
S1411 Phosphorylation HPRD 18691976


Q14004 (CDK13) as PTM Enzyme



Substrate Site Score Source PMID
P23588 (EIF4B) S422 Signor 36882522
P24928 (POLR2A) S1616 PhosphoSitePlus   Signor 26748711, 32917631, 25561469
P24928 (POLR2A) S1619 PhosphoSitePlus 26748711, 25561469
P24928 (POLR2A) S1623 Signor 32917631
P24928 (POLR2A) S1644 Signor 32917631
P24928 (POLR2A) S1651 Signor 32917631
P24928 (POLR2A) S1665 Signor 32917631
P24928 (POLR2A) S1672 Signor 32917631
P24928 (POLR2A) S1693 Signor 32917631
P24928 (POLR2A) S1714 Signor 32917631
P24928 (POLR2A) S1721 Signor 32917631
P24928 (POLR2A) S1735 Signor 32917631
P24928 (POLR2A) S1763 Signor 32917631
P24928 (POLR2A) S1784 Signor 32917631
P24928 (POLR2A) S1861 Signor 32917631
P24928 (POLR2A) S1868 Signor 32917631
P24928 (POLR2A) S1875 Signor 32917631
P24928 (POLR2A) S1878 Signor 32917631
P24928 (POLR2A) S1882 Signor 32917631
P24928 (POLR2A) S1889 Signor 32917631
P24928 (POLR2A) S1896 Signor 32917631
P24928 (POLR2A) S1910 Signor 32917631
P24928 (POLR2A) S1917 Signor 32917631
P24928 (POLR2A) S1924 Signor 32917631
P24928 (POLR2A) S1931 Signor 32917631
P24928 (POLR2A) S1941 Signor 32917631
P24928 (POLR2A) S1948 Signor 32917631
Q13541 (EIF4EBP1) T46 Signor 36882522


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S260 R260 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S291 L291 Biomuta DOID:5041 / esophageal cancer [ tcga ]
S340 F340 Biomuta DOID:1324 / lung cancer [ cosmic ]
S367 P367 Biomuta DOID:4159 / skin cancer [ cosmic ]
S369 G369 Biomuta DOID:1324 / lung cancer [ cosmic ]
S375 T375 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y376 C376 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y376 H376 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S383 P383 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S383 F383 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S400 I400 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
Y415 H415 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S439 F439 Biomuta DOID:1324 / lung cancer [ cosmic ]
S490 L490 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T500 A500 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic, icgc ]
T500 M500 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S525 F525 Biomuta DOID:4159 / skin cancer [ cosmic ]
S527 * Biomuta DOID:1612 / breast cancer [ cosmic ]
K566 N566 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S662 L662 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y870 N870 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
T1058 A1058 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1066 L1066 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T1083 I1083 Biomuta DOID:263 / kidney cancer [ cosmic ]
S1086 P1086 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
T1143 I1143 Biomuta DOID:263 / kidney cancer [ cosmic ]
S1146 P1146 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S1153 L1153 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]
T1186 M1186 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
K1199 T1199 Biomuta [ cosmic ] DOID:1612 / breast cancer [ icgc ]
T1246 M1246 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
T1287 I1287 Biomuta DOID:1319 / brain cancer [ icgc ]
K1316 N1316 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1331 C1331 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S1346 C1346 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1411 G1411 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:3571 / liver cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, cosmic ] DOID:2531 / hematologic cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic, cosmic ] DOID:9256 / colorectal cancer [ cosmic, cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, cosmic, icgc ]
S1471 G1471 Biomuta DOID:9256 / colorectal cancer [ cosmic ]