Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13976 / KGP1_HUMAN
Protein Name cGMP-dependent protein kinase 1
Gene Name Name: PRKG1
Synonyms:PRKG1B,PRKGR1A,PRKGR1B;
Organism Homo sapiens (Human)

PRO ID PR:Q13976
DAG View
PRO Name cGMP-dependent protein kinase 1 (human)
Definition A cGMP-dependent protein kinase 1 that is encoded in the genome of human.
Short Label hPRKG1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13976 (PRKG1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 22223895
S2 Phosphorylation PhosphoSitePlus
S27 Phosphorylation PhosphoSitePlus
S51 Phosphorylation PhosphoSitePlus
T59 Phosphorylation P17252 (PRKCA) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 12609995
S65 Phosphorylation Q13976 (PRKG1) PhosphoSitePlus   Signor 12080049, 19168131
T85 Phosphorylation PhosphoSitePlus
Y212 Phosphorylation PhosphoSitePlus
S218 Phosphorylation PhosphoSitePlus
S231 Phosphorylation PhosphoSitePlus
Y247 Phosphorylation PhosphoSitePlus
S273 Phosphorylation PhosphoSitePlus
Y433 Phosphorylation PhosphoSitePlus
Y435 Phosphorylation PhosphoSitePlus
Y497 Phosphorylation PhosphoSitePlus
T515 Phosphorylation PhosphoSitePlus
T517 Phosphorylation PhosphoSitePlus
K607 Acetylation PhosphoSitePlus
K615 Acetylation PhosphoSitePlus
K617 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T57 Phosphorylation P17252 (PRKCA) HPRD 12609995


Q13976 (PRKG1) as PTM Enzyme



Substrate Site Score Source PMID
O14974 (PPP1R12A) S692 neXtProt 15194681, 10567269
O14974 (PPP1R12A) S695 neXtProt 15194681, 10567269
O14974 (PPP1R12A) S852 neXtProt 15194681, 10567269
O76074-2 (PDE5A) S60 HPRD 2168396
O76074-1 (PDE5A) S102 HPRD   PhosphoSitePlus 11723116, 2168396
O96001-1 (PPP1R17) T68 HPRD 10051666
O96001-1 (PPP1R17) T119 HPRD 10051666
P04792 (HSPB1) S15 PhosphoSitePlus 11383510
P04792 (HSPB1) S78 PhosphoSitePlus   Signor 11383510, 19593530
P04792 (HSPB1) S82 PhosphoSitePlus   Signor 11383510, 19593530
P04792 (HSPB1) T143 PhosphoSitePlus   Signor 11383510, 19593530
P10451-5 (SPP1) S148 HPRD 8663267
P11831 (SRF) T159 PhosphoSitePlus   Signor 19778940
P13569 (CFTR) S660 HPRD   Signor 1377674, 10581361
P13569-1 (CFTR) S700 HPRD 1377674
P13569-1 (CFTR) S737 HPRD   Signor 1377674, 10581361
P13569-1 (CFTR) S768 HPRD   Signor 1377674, 10581361
P13569 (CFTR) S795 HPRD   Signor 1377674, 10581361
P13569-1 (CFTR) S813 HPRD   Signor 1377674, 10581361
P16220-1 (CREB1) S133 HPRD 11175347, 9687510, 8688081, ...9829964
P19429 (TNNI3) S23 Signor 15769444
P19429 (TNNI3) S24 Signor 15769444
P21731-2 (TBXA2R) S330 PhosphoSitePlus 14530262
P21731-2 (TBXA2R) T332 PhosphoSitePlus 14530262
P21817-1 (RYR1) S2843 HPRD 8380342, 14532276
P24046-1 (GABRR1) S444 HPRD 12175859
P31645 (SLC6A4) T276 PhosphoSitePlus   Signor 17310063, 17913921
P35367 (HRH1) S396 PhosphoSitePlus 15107581
P35367 (HRH1) S398 PhosphoSitePlus   Signor 15107581, 10101032
P35520 (CBS) S227 PhosphoSitePlus 26368121
P35520 (CBS) S525 PhosphoSitePlus 26368121
P41220-1 (RGS2) S46 HPRD   neXtProt   PhosphoSitePlus 14608379
P41220 (RGS2) S64 HPRD   neXtProt   PhosphoSitePlus 14608379
P50552 (VASP) S157 HPRD   neXtProt   PhosphoSitePlus   Signor 12576312, 8182057, 14679200, ...20058876
P50552 (VASP) S239 HPRD   neXtProt   PhosphoSitePlus   Signor 12576312, 8182057, 22942288, ...17287340, 15694326, 20483741, 20166139, 14679200, 18637808
P50552 (VASP) T278 HPRD   neXtProt   PhosphoSitePlus   Signor 12576312, 8182057, 18637808
P52943-1 (CRIP2) S104 HPRD 10681529
P61224 (RAP1B) S179 PhosphoSitePlus 1551424
P61586 (RHOA) S188 neXtProt   PhosphoSitePlus 11162591, 19737918
P78347-2 (GTF2I) S371 HPRD   PhosphoSitePlus 16055503, 12082086
P78347-4 (GTF2I) S391 HPRD 12082086
P78347-3 (GTF2I) S392 HPRD 12082086
P78347 (GTF2I) S412 HPRD   neXtProt   PhosphoSitePlus   Signor 12082086
P78347-2 (GTF2I) S743 HPRD   PhosphoSitePlus 19651622, 16055503, 12082086, ...20068231
P78347-4 (GTF2I) S763 HPRD 19651622, 12082086, 20068231
P78347-3 (GTF2I) S764 HPRD 19651622, 12082086, 20068231
P78347 (GTF2I) S784 HPRD   neXtProt   PhosphoSitePlus   Signor 19651622, 12082086, 20068231
Q01970-1 (PLCB3) S26 HPRD 11278298
Q01970-1 (PLCB3) S1105 HPRD 19651622, 11278298
Q03393 (PTS) S19 PhosphoSitePlus   Signor 10531334
Q05469 (LIPE) S853 PhosphoSitePlus 2537200
Q12791 (KCNMA1) S811 neXtProt 23407708
Q12791 (KCNMA1) S992 neXtProt 23407708
Q12791 (KCNMA1) S1204 neXtProt 23407708
Q13153 (PAK1) S21 PhosphoSitePlus 16490784
Q13507-3 (TRPC3) T11 HPRD   PhosphoSitePlus   Signor 16331690, 14983059
Q13507 (TRPC3) S251 PhosphoSitePlus   Signor 16331690, 14983059
Q13507-3 (TRPC3) S263 HPRD 14983059
Q13976 (PRKG1) S65 PhosphoSitePlus   Signor 12080049, 19168131
Q14847 (LASP1) S146 PhosphoSitePlus   Signor 12571245
Q15052 (ARHGEF6) S684 PhosphoSitePlus 26507661
Q15637-1 (SF1) S20 HPRD 10449420, 17287340
Q5VSY0-1 (GKAP1) S106 HPRD 10671526
Q684P5 (RAP1GAP2) S7 PhosphoSitePlus 15632203
Q76M96 (CCDC80) S409 PhosphoSitePlus 23831687
Q76M96 (CCDC80) S434 PhosphoSitePlus 23831687
Q8WZ42 (TTN) S4185 PhosphoSitePlus 19023132
Q92934 (BAD) S118 neXtProt 20043968
Q96A00 (PPP1R14A) T38 PhosphoSitePlus 12804574
Q96D31 (ORAI1) S34 PhosphoSitePlus 26269433
Q9HCX4 (TRPC7) T15 neXtProt 21402151
Q9NS28 (RGS18) S216 PhosphoSitePlus 22234696
Q9UH03-1 (SEPT3) S91 HPRD 15107017
Q9UIK4 (DAPK2) S299 neXtProt 22580283
Q9UIK4 (DAPK2) S367 neXtProt 22580283
Q9UIK4 (DAPK2) S368 neXtProt 22580283
Q9Y210 (TRPC6) T70 PhosphoSitePlus 19961855, 23814119
Q9Y210 (TRPC6) S322 PhosphoSitePlus 19961855
Q9Y613 (FHOD1) S1131 PhosphoSitePlus   Signor 21106951, 15051728
Q9Y6F6 (MRVI1) S657 neXtProt 16990611


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S51 L51 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
Y212 C212 Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:0070003 / blastoma [ cosmic ]
S218 R218 Biomuta DOID:1324 / lung cancer [ tcga ]
S273 T273 Biomuta DOID:1324 / lung cancer [ cosmic ]