Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13972 / RGRF1_HUMAN
Protein Name Ras-specific guanine nucleotide-releasing factor 1
Gene Name Name: RASGRF1
Synonyms:CDC25,GNRP,GRF1;
Organism Homo sapiens (Human)

PRO ID PR:Q13972
DAG View
PRO Name Ras-specific guanine nucleotide-releasing factor 1 (human)
Definition A Ras-specific guanine nucleotide-releasing factor 1 that is encoded in the genome of human.
Short Label hRASGRF1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13972 (RASGRF1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S14 Phosphorylation PhosphoSitePlus
S287 Phosphorylation O96017 (CHEK2) Signor 17110335
S481 Phosphorylation PhosphoSitePlus
S709 Phosphorylation PhosphoSitePlus
S730 Phosphorylation PhosphoSitePlus
S738 Phosphorylation PhosphoSitePlus
S750 Phosphorylation neXtProt   PhosphoSitePlus 16921254
S752 Phosphorylation PhosphoSitePlus
S758 Phosphorylation PhosphoSitePlus
S787 Phosphorylation PhosphoSitePlus
N872 N-Glycosylation GlyGen 29671580
S927 Phosphorylation P17612 (PRKACA) PhosphoSitePlus   RLIMS-P   Signor 10601308, 15853814
T1023 Phosphorylation PhosphoSitePlus
S1090 Phosphorylation PhosphoSitePlus
S1095 Phosphorylation PhosphoSitePlus
S1252 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S927 Phosphorylation P17612 (PRKACA) HPRD 12538592
Site PTM Type PTM Enzyme Score Source PMID
S143 Phosphorylation P17612 (PRKACA) HPRD 12538592


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S709 L709 Biomuta DOID:2394 / ovarian cancer [ icgc ] DOID:2994 / germ cell cancer [ cosmic ]
S730 F730 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
N872 K872 Biomuta DOID:2531 / hematologic cancer [ icgc ]