iPTMnet Report for Q13950 (RUNX2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13950 / RUNX2_HUMAN
Protein Name Runt-related transcription factor 2
Gene Name Name: RUNX2
Synonyms:AML3,CBFA1,OSF2,PEBP2A;
Organism Homo sapiens (Human)

PRO ID PR:Q13950
DAG View
PRO Name runt-related transcription factor 2 (human)
Definition A runt-related transcription factor 2 that is encoded in the genome of human.
Short Label hRUNX2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13950 (RUNX2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S24 Phosphorylation P27361 (MAPK3) phospho.ELM   PhosphoSitePlus 19801668
S28 Phosphorylation P31749 (AKT1) , P27361 (MAPK3) IEDB   phospho.ELM   PhosphoSitePlus 12231506, 23389849, 32387766, ...19801668
S32 O-Glycosylation GlyGen   PhosphoSitePlus 29315243, 33214551, 17707335, ...35254053, 34019948, 36861967, 31779679, 25187572
S33 O-Glycosylation GlyGen   PhosphoSitePlus 29315243, 33214551, 17707335, ...35254053, 34019948, 36861967, 31779679, 25187572
S33 Phosphorylation PhosphoSitePlus
S43 Phosphorylation P27361 (MAPK3) phospho.ELM   PhosphoSitePlus 19801668
S118 Phosphorylation P45983 (MAPK8) phospho.ELM   PhosphoSitePlus   RLIMS-P 12231506, 16443755, 29988028, ...22247071
K176 Ubiquitination PhosphoSitePlus
S196 Phosphorylation P31749 (AKT1) PhosphoSitePlus 23389849
T198 Phosphorylation P31749 (AKT1) PhosphoSitePlus 23389849
T200 Phosphorylation P31749 (AKT1) PhosphoSitePlus 23389849
S237 Phosphorylation PhosphoSitePlus
K238 Acetylation PhosphoSitePlus
K238 Ubiquitination PhosphoSitePlus
S247 Phosphorylation PhosphoSitePlus
R258 Methylation PhosphoSitePlus
R267 Methylation PhosphoSitePlus
S269 Phosphorylation PhosphoSitePlus
S275 Phosphorylation P27361 (MAPK3) phospho.ELM   PhosphoSitePlus 19801668
S294 Phosphorylation P27361 (MAPK3) phospho.ELM   PhosphoSitePlus   Signor 19801668
S312 Phosphorylation P27361 (MAPK3) phospho.ELM   PhosphoSitePlus   Signor 19801668
S314 Phosphorylation P27361 (MAPK3) phospho.ELM   PhosphoSitePlus 19801668
T333 O-Glycosylation GlyGen 29315243, 33214551, 17707335, ...35254053, 34019948, 36861967, 31779679, 25187572
S340 Phosphorylation P27361 (MAPK3) phospho.ELM   PhosphoSitePlus   UniProt 19801668, 18220336
S347 Phosphorylation PhosphoSitePlus
S371 O-Glycosylation GlyGen   PhosphoSitePlus 29315243, 33214551, 17707335, ...35254053, 34019948, 36861967, 31779679, 25187572
S378 Phosphorylation PhosphoSitePlus
R386 Methylation PhosphoSitePlus
S388 Phosphorylation PhosphoSitePlus
S451 Phosphorylation RLIMS-P   UniProt 29050333, 16407259
S465 Phosphorylation P06493 (CDK1) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 12231506, 16407259
S480 Phosphorylation neXtProt 16613857
S499 Phosphorylation phospho.ELM   PhosphoSitePlus 12231506
S503 Phosphorylation P27361 (MAPK3) phospho.ELM   PhosphoSitePlus 12231506, 19801668
Y521 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S28 Phosphorylation HPRD 12231506
S118 Phosphorylation HPRD 12231506
S465 Phosphorylation HPRD 12231506
Site PTM Type PTM Enzyme Score Source PMID
S451 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S28 Phosphorylation HPRD 12231506
S118 Phosphorylation HPRD 12231506
S340 Phosphorylation PhosphoSitePlus
S343 Phosphorylation PhosphoSitePlus
S443 Phosphorylation HPRD 12231506


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S247 I247 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S312 F312 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S340 * Biomuta DOID:1612 / breast cancer [ cosmic ]
R386 C386 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S480 N480 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S499 N499 Biomuta DOID:4159 / skin cancer [ cosmic ]
S503 Y503 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic ]
S503 F503 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]