Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13946 / PDE7A_HUMAN
Protein Name High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
Gene Name Name: PDE7A
Organism Homo sapiens (Human)

PRO ID PR:Q13946
DAG View
PRO Name high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (human)
Definition A high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A that is encoded in the genome of human.
Short Label hPDE7A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13946 (PDE7A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R24 Methylation PhosphoSitePlus
R48 Methylation PhosphoSitePlus
T59 Phosphorylation phospho.ELM 9195912
S79 Phosphorylation PhosphoSitePlus
S84 Phosphorylation PhosphoSitePlus
S113 Phosphorylation PhosphoSitePlus
K145 Ubiquitination PhosphoSitePlus
S306 Phosphorylation PhosphoSitePlus
K359 Ubiquitination PhosphoSitePlus
K374 Ubiquitination PhosphoSitePlus
K379 Ubiquitination PhosphoSitePlus
K392 Ubiquitination PhosphoSitePlus
K393 Ubiquitination PhosphoSitePlus
K448 Ubiquitination PhosphoSitePlus
S450 Phosphorylation PhosphoSitePlus
K452 Ubiquitination PhosphoSitePlus
S459 Phosphorylation PhosphoSitePlus
T464 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T59 I59 Biomuta DOID:3070 / malignant glioma [ tcga ]
S306 C306 Biomuta DOID:3070 / malignant glioma [ tcga ]
S306 I306 Biomuta DOID:3070 / malignant glioma [ tcga ]
K452 T452 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
T464 A464 Biomuta DOID:1909 / melanoma [ icgc, tcga ]