iPTMnet Report for Q13905 (RAPGEF1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13905 / RPGF1_HUMAN
Protein Name Rap guanine nucleotide exchange factor 1
Gene Name Name: RAPGEF1
Synonyms:GRF2;
Organism Homo sapiens (Human)

PRO ID PR:Q13905
DAG View
PRO Name Rap guanine nucleotide exchange factor 1 (human)
Definition A Rap guanine nucleotide exchange factor 1 that is encoded in the genome of human.
Short Label hRAPGEF1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13905 (RAPGEF1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S12 Phosphorylation PhosphoSitePlus
S23 Phosphorylation PhosphoSitePlus
Y61 Phosphorylation PhosphoSitePlus
S76 Phosphorylation PhosphoSitePlus
T109 Phosphorylation PhosphoSitePlus
K200 Ubiquitination PhosphoSitePlus
S214 Phosphorylation PhosphoSitePlus
S217 Phosphorylation PhosphoSitePlus
S222 Phosphorylation PhosphoSitePlus
S223 Phosphorylation PhosphoSitePlus
S253 Phosphorylation PhosphoSitePlus
T261 Phosphorylation PhosphoSitePlus
S281 Phosphorylation PhosphoSitePlus   UniProt 23186163
S293 Phosphorylation PhosphoSitePlus   UniProt 21406692
S296 Phosphorylation PhosphoSitePlus
S307 Phosphorylation PhosphoSitePlus
T310 Phosphorylation PhosphoSitePlus
S311 Phosphorylation PhosphoSitePlus
S313 Phosphorylation PhosphoSitePlus
S314 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y329 Phosphorylation PhosphoSitePlus
S335 Phosphorylation IEDB   PhosphoSitePlus   UniProt 27920218, 23186163, 27869121
S338 Phosphorylation PhosphoSitePlus
Y341 Phosphorylation PhosphoSitePlus
S345 Phosphorylation PhosphoSitePlus
S349 Phosphorylation PhosphoSitePlus
S352 Phosphorylation PhosphoSitePlus
S353 Phosphorylation PhosphoSitePlus
S358 Phosphorylation PhosphoSitePlus
S360 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332
S366 Phosphorylation PhosphoSitePlus
S371 Phosphorylation PhosphoSitePlus
Y390 Phosphorylation PhosphoSitePlus
S423 Phosphorylation PhosphoSitePlus
S463 Phosphorylation PhosphoSitePlus
S466 Phosphorylation PhosphoSitePlus
C474 Methylation IEDB 31844290
S501 Phosphorylation IEDB 32157095
Y504 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 10318861, 14551197, 18809728, ...21876762, 15320955, 20581864, 18957052, 24396067, 30567575, 28273099, 12734187
Y504 Phosphorylation P00519 (ABL1) PhosphoSitePlus   Signor 20581864
Y504 Phosphorylation P08631 (HCK) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 24396067, 15320955, 14551197
Y504 Phosphorylation P12931 (SRC) phospho.ELM   PhosphoSitePlus   Signor 15320955
Y554 Phosphorylation PhosphoSitePlus
Y561 Phosphorylation PhosphoSitePlus
Y570 Phosphorylation PhosphoSitePlus
T572 Phosphorylation PhosphoSitePlus
Y579 Phosphorylation PhosphoSitePlus
S652 Phosphorylation PhosphoSitePlus
K683 Ubiquitination PhosphoSitePlus
Y715 Phosphorylation PhosphoSitePlus
Y723 Phosphorylation PhosphoSitePlus
K808 Ubiquitination PhosphoSitePlus
T819 Phosphorylation PhosphoSitePlus
S820 Phosphorylation PhosphoSitePlus
K869 Ubiquitination PhosphoSitePlus
T950 Phosphorylation PhosphoSitePlus
S951 Phosphorylation PhosphoSitePlus
S965 Phosphorylation PhosphoSitePlus
S966 Phosphorylation PhosphoSitePlus
T1067 Phosphorylation PhosphoSitePlus
T1071 Phosphorylation PhosphoSitePlus
T1077 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T109 Phosphorylation HPRD 19664994
T298 Phosphorylation HPRD 17081983
T310 Phosphorylation HPRD 15144186
S311 Phosphorylation HPRD 15144186
S314 Phosphorylation HPRD 15144186
S360 Phosphorylation HPRD 17081983
Y504 Phosphorylation HPRD 10318861, 12734187, 14551197
Y504 Phosphorylation P08631 (HCK) HPRD 10318861, 12734187, 14551197
Site PTM Type PTM Enzyme Score Source PMID
K57 Sumoylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T127 Phosphorylation HPRD 19664994
T316 Phosphorylation HPRD 17081983
T328 Phosphorylation HPRD 15144186
S329 Phosphorylation HPRD 15144186
S332 Phosphorylation HPRD 15144186
S378 Phosphorylation HPRD 17081983
Y522 Phosphorylation HPRD 10318861, 12734187, 14551197
Y522 Phosphorylation P08631 (HCK) HPRD 10318861, 12734187, 14551197


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P46108 (CRK) Y221 Q13905 (RAPGEF1) inhibited_association eFIP 19001122


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K200 R200 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T261 M261 Biomuta DOID:363 / uterine cancer [ icgc ]
S281 I281 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T298 A298 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic, icgc ]
S313 P313 Biomuta DOID:363 / uterine cancer [ cosmic ]
T316 A316 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic, icgc ]
S349 P349 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ]
S349 F349 Biomuta DOID:4159 / skin cancer [ cosmic ]
S358 I358 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S358 N358 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S366 T366 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S423 F423 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
S463 N463 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y554 H554 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y570 N570 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y570 F570 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T572 M572 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
Y579 C579 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
Y715 F715 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T1077 S1077 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]