iPTMnet Report for Q13882 (PTK6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13882 / PTK6_HUMAN
Protein Name Protein-tyrosine kinase 6
Gene Name Name: PTK6
Synonyms:BRK;
Organism Homo sapiens (Human)

PRO ID PR:Q13882
DAG View
PRO Name protein-tyrosine kinase 6 (human)
Definition A protein-tyrosine kinase 6 that is encoded in the genome of human.
Short Label hPTK6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13882 (PTK6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y13 Phosphorylation Q13882 (PTK6) UniProt 12121988
Y61 Phosphorylation Q13882 (PTK6) UniProt 12121988
Y66 Phosphorylation Q13882 (PTK6) UniProt 12121988
S111 Phosphorylation PhosphoSitePlus
Y114 Phosphorylation Q13882 (PTK6) PhosphoSitePlus   UniProt 18691976, 12121988
S117 Phosphorylation PhosphoSitePlus
Y127 Phosphorylation PhosphoSitePlus
S159 Phosphorylation PhosphoSitePlus
S279 Phosphorylation PhosphoSitePlus
Y342 Phosphorylation Q13882 (PTK6) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 22231447, 12121988, 11114724, ...14676834, 22084245, 25153721, 25897081, 29879184, 23552639, 29142193
S344 Phosphorylation PhosphoSitePlus
Y351 Phosphorylation Q13882 (PTK6) phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 26751287, 12121988
K352 Ubiquitination PhosphoSitePlus
T445 Phosphorylation PhosphoSitePlus
S446 Phosphorylation PhosphoSitePlus
Y447 Phosphorylation Q13882 (PTK6) , Q9H3Y6 (SRMS) IntAct   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 12121988, 14676834, 18083107, ...25897081, 10913193, 15056653, 23552639, 29142193
Site PTM Type PTM Enzyme Score Source PMID
Y114 Phosphorylation HPRD 18691976
S159 Phosphorylation HPRD 18691976
Y342 Phosphorylation Q13882 (PTK6) HPRD 12121988
S446 Phosphorylation HPRD 18691976
Y447 Phosphorylation Q13882 (PTK6) HPRD 17016520, 17389395, 12121988


Q13882 (PTK6) as PTM Enzyme



Substrate Site Score Source PMID
P00533 (EGFR) Y869 neXtProt 22231447
P31749 (AKT1) Y315 neXtProt   PhosphoSitePlus   Signor 20606012, 15994200
P31749 (AKT1) Y326 neXtProt   PhosphoSitePlus   Signor 20606012
P35222 (CTNNB1) Y64 neXtProt   PhosphoSitePlus 20026641
P35222 (CTNNB1) Y142 neXtProt   PhosphoSitePlus 20026641
P35222 (CTNNB1) Y331 neXtProt   PhosphoSitePlus 20026641
P35222 (CTNNB1) Y333 neXtProt   PhosphoSitePlus 20026641
P40763 (STAT3) Y705 neXtProt 21741923, 19304789
P42229 (STAT5A) Y694 neXtProt 21205088
P49023 (PXN) Y31 neXtProt   PhosphoSitePlus 15572663, 19304789
P49023-2 (PXN) Y118 neXtProt   PhosphoSitePlus 15572663, 19304789
P51692 (STAT5B) Y699 neXtProt   PhosphoSitePlus   Signor 17997837, 21205088
P56945 (BCAR1) Y165 neXtProt   PhosphoSitePlus   Signor 22084245
P56945 (BCAR1) Y224 neXtProt 22084245
P56945 (BCAR1) Y234 neXtProt 22084245
P56945 (BCAR1) Y249 neXtProt 22084245
P56945 (BCAR1) Y262 neXtProt 22084245
P56945 (BCAR1) Y267 neXtProt 22084245
P56945 (BCAR1) Y287 neXtProt 22084245
P56945 (BCAR1) Y306 neXtProt 22084245
P56945 (BCAR1) Y327 neXtProt 22084245
P56945 (BCAR1) Y362 neXtProt 22084245
P56945 (BCAR1) Y387 neXtProt 22084245
P56945 (BCAR1) Y664 neXtProt   PhosphoSitePlus   Signor 22084245
Q05397 (PTK2) Y861 neXtProt 23027128
Q07666-1 (KHDRBS1) Y435 HPRD   neXtProt   Signor 16179349, 10913193, 19304789
Q07666 (KHDRBS1) Y440 HPRD   neXtProt   Signor 16179349, 10913193, 19304789
Q07666-1 (KHDRBS1) Y443 HPRD   neXtProt   Signor 16179349, 10913193, 19304789
Q12929 (EPS8) Y498 Signor 27738316
Q12929 (EPS8) Y525 Signor 28214294
Q12929 (EPS8) Y535 Signor 28214294
Q13017 (ARHGAP5) Y1109 PhosphoSitePlus   Signor 18829532
Q13882 (PTK6) Y13 UniProt 12121988
Q13882 (PTK6) Y61 UniProt 12121988
Q13882 (PTK6) Y66 UniProt 12121988
Q13882 (PTK6) Y114 UniProt 12121988
Q13882-1 (PTK6) Y342 HPRD   neXtProt   PhosphoSitePlus   Signor   UniProt 11114724, 14676834, 12121988, ...22231447
Q13882 (PTK6) Y351 UniProt 12121988
Q13882 (PTK6) Y447 HPRD   PhosphoSitePlus   Signor 17016520, 14676834, 17389395, ...12121988
Q96P48 (ARAP1) Y231 neXtProt   PhosphoSitePlus   Signor 20554524
Q99704 (DOK1) Y362 RLIMS-P+ 24523872
Q9NRY4 (ARHGAP35) Y1105 neXtProt 18829532
Q9UGK3 (STAP2) Y250 neXtProt   PhosphoSitePlus   Signor 19393627


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048955 (hPTK6/Phos:1) pY342 PRO
PR:000048956 (hPTK6/Phos:2) pY342,pY447 PRO
PR:000048957 (hPTK6/Phos:3) pY351 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y114 H114 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S117 P117 Biomuta DOID:10283 / prostate cancer [ cosmic ]